CHARACTERIZATION, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF MANGOSTEEN (Garcinia Mangostana L.) PERICARP NANOSIZED EXTRACT

doi:10.7324/rjc.2017.1031766

Cited by 7 publications

(6 citation statements)

References 12 publications

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“…Free radical scavenging activity was determined using DPPH method [12][13][14] . Gallic acid, which is known to have a strong antioxidant activity, was used as reference standard.…”

Section: Free Radical Scavenging Activitymentioning

confidence: 99%

Solid Dispersion of Usnic Acid-PVP K30 and Evaluation of Antioxidant Activity

Fitriani¹,

Rismawati²,

Umar³

et al. 2018

RJC

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Usnic acid, a compound produced by Usnea sp, has been reported for anti-oxidant activity. However, the use of usnic acid is still finite due to poor solubility in water. One of the processes to increase the solubility is by preparing into solid dispersion using hydrophilic polymer. The aims of this study were to prepare usnic acid in solid dispersion using poly-vinyl-pyrrolidone (PVP) K30 and evaluate its antioxidant activity. Solid dispersions were prepared using spray and freeze-drying method at a ratio of usnic acid:PVP of 1:1 and 1:2 (w/w). The physical mixture at the same ratio was prepared as a comparison. The morphology of solid dispersion, which was depicted in scanning electron microscopy (SEM) analysis, showed rod crystal for usnic acid; sphere particles for PVP K30 and spray dried powder; porous particles for freeze-dried powder, and usnic acid embedded on the surface of PVP K-30 for the physical mixture. The amount of usnic acid dissolved in water was determined using a UV-Vis spectrophotometer. Freeze dried usnic acid-PVP at ratio 1:2 showed the highest solubility which was about 20-fold compared to intact usnic acid. Antioxidant activity was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and gallic acid was used as the reference. The result of antioxidant activity test showed the inhibition concentration 50% (IC50) were 12.471, 80.242 and 63.867 µg/ml for gallic acid, intact usnic acid and freeze-dried usnic acid at ratio 1:2, respectively. In conclusion, solid dispersion is able to increase the solubility of usnic acid and the antioxidant activity is in accordance with the solubility result.

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“…Free radical scavenging activity was determined using DPPH method [12][13][14] . Gallic acid, which is known to have a strong antioxidant activity, was used as reference standard.…”

Section: Free Radical Scavenging Activitymentioning

confidence: 99%

Solid Dispersion of Usnic Acid-PVP K30 and Evaluation of Antioxidant Activity

Fitriani¹,

Rismawati²,

Umar³

et al. 2018

RJC

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“…Lalitha et al (2017) showed that ethyl acetate extract of mangosteen leaf was able to inhibit the growth of various bacteria ( Staphylococcus epidermidis , Staphylococcus aureus , Micrococcus luteus , Enterobacter aerogenes , Escherichia coli , Vibrio parahaemolyticus , Proteus vulgaris , Klebsiella pneumoniae , Yersinia enterocolitica, and Salmonella typhimurium ) and fungi ( Trichophyton mentagrophytes 66/01 and T. rubrum 57/01). Nanosized mangosteen pericarp extract has also been shown to possess anti-bacterial properties against Staphylococcus aureus , Bacillus cereus and Shigella flexneri (Sugita et al, 2017). Furthermore, both water (1 mg/mL) and methanol (8.75 μg/mL) extracts of mangosteen pericarp were able to reduce interleukin-6 (IL-6) cytokine production in whole human blood assay infected with Escherichia coli (Elisia et al, 2018), suggesting that the extracts may not just kill bacteria but also act as an anti-inflammatory agent in humans.…”

Section: Introductionmentioning

confidence: 99%

Recent updates on metabolite composition and medicinal benefits of mangosteen plant

Aizat¹,

Jamil²,

Ahmad-Hashim³

et al. 2019

PeerJ

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Background Mangosteen (Garcinia mangostana L.) fruit has a unique sweet-sour taste and rich in beneficial compounds such as xanthones. Mangosteen has been originally used in various folk medicines to treat diarrhea, wound, and fever. More recently, it has been used as a major component in health supplement products for weight loss and promoting general health. This is perhaps due to its known medicinal benefits including as anti-oxidant and anti-inflammation. Interestingly, the publications related to mangosteen has surged in recent years suggesting its popularity and usefulness in research laboratories. However, there is still no updated reviews (up to 2018) in this booming research area, particularly on its metabolite composition and medicinal benefits. Method In this review, we have covered recent articles within the year of 2016 to 2018, which focuses on several aspects including the latest findings on compound composition from mangosteen fruit as well as its medicinal usages. Result Mangosteen has been vastly used in medicinal areas including as anti-cancer, anti-microbial, and anti-diabetes treatments. Furthermore, we have also described the benefits of mangosteen extract in protecting various human organs such as liver, skin, joint, eye, neuron, bowel, and cardiovascular tissues against disorders and diseases. Conclusion All in all, this review describes the numerous manipulations of mangosteen extracted compounds in medicinal areas and highlights the current trend of its research. This will be important for future directed research and may allow researchers to tackle the next big challenge in mangosteen study; drug development and human applications.

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“…The alkaloidal fractions were separated from ethyl acetate extract using acid-base method 7 . The ethyl acetate extract-free alkaloid (13 g), was fractionated by VLC using gradient elution (n-hexane -ethyl acetate-methanol) 8 to give five significant fractions (A-E). Fraction C was sub-fractionated by radial chromatography using n-hexane -ethyl acetate (9:1.5, v/v) to give eight fractions (C1-C8).…”

Section: Extraction and Isolationmentioning

confidence: 99%

NATURAL ANTHRAQUINONEFROM THE BARK OF Cinchona officinalis L.

Insanu¹,

Aziz²,

Fidrianny³

et al. 2019

RJC

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Cinchona officinalis is known as the source of alkaloid compounds. Almost 7-12 % of alkaloids were contained in its bark. Not many studies reported other chemical compounds in it. This research aimed to isolate non-alkaloid compounds in the C. officinalis bark. It was extracted by maceration using n-hexane, ethyl acetate, and ethanol. The alkaloidal fraction was separated from ethylacetate extract based on acid-base reaction. The fractions were continued to the next step of fractionations using vacuum liquid chromatography (VLC) and radial chromatography to yield compound 1. Characterizations of compound 1 were done by spectroscopic methods (UV, IR, ESI-MS, NMR ( 1 H-, 13 C-, HSQC, and HMBC)).The maximum wavelengths of compound 1 were 278 and 430 nm. 1 H-dan 13 C-NMR data showed that compound 1 consisted of ten hydrogens and fifteen carbons. ESI-MS showed that the molecular weight was 285.96. It was predicted as 1,3,8-trihydroxy-2-methoxy-9,10-anthraquinone. It was firstly isolated from the ethyl acetate extract of C.officinalis bark.

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CHARACTERIZATION, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF MANGOSTEEN (Garcinia Mangostana L.) PERICARP NANOSIZED EXTRACT

Cited by 7 publications

References 12 publications

Solid Dispersion of Usnic Acid-PVP K30 and Evaluation of Antioxidant Activity

Solid Dispersion of Usnic Acid-PVP K30 and Evaluation of Antioxidant Activity

Recent updates on metabolite composition and medicinal benefits of mangosteen plant

NATURAL ANTHRAQUINONEFROM THE BARK OF Cinchona officinalis L.

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