Characterization, antioxidant and immunomodulatory effects of selenized polysaccharides from dandelion roots

Wang, Libo; Li, Lianyu; Gao, Jingyu; Huang, Jing; Yang, Yu; Xu, Yaqin; Liu, Shuang; Yu, Wenqing

doi:10.1016/j.carbpol.2021.117796

Cited by 100 publications

(44 citation statements)

References 46 publications

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“…It should be noted that some other pectins demonstrate DPPH scavenging activity at much higher concentrations. These include pectins from hawthorn wine pomace (1.71 and 2.10 mg/mL) [ 42 ], dandelion roots (>2.5 mg/mL) [ 43 ], apple pomace (3.02–5.24 mg/mL) [ 19 ], Cassia seed (4.41 and 5.83 mg/mL) [ 10 ] and quinoa (5.22–15.22 mg/mL) [ 9 ].…”

Section: Resultsmentioning

confidence: 99%

Isolation, Chemical Characterization and Antioxidant Activity of Pectic Polysaccharides of Fireweed (Epilobium angustifolium L.)

Popov¹,

Смирнов²,

Kvashninova³

et al. 2021

Molecules

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The aim of this study was to isolate pectins with antioxidant activity from the leaves of Epilobium angustifolium L. Two pectins, EA-4.0 and EA-0.8, with galacturonic acid contents of 88 and 91% were isolated from the leaves of E. angustifolium L. by the treatment of plant raw materials with aqueous hydrochloric acid at pH 4.0 and 0.8, respectively. EA-4.0 and EA-0.8 were found to scavenge the DPPH radical in a concentration-dependent manner at 17–133 μg/mL, whereas commercial apple pectin scavenged at 0.5–2 mg/mL. The antioxidant activity of EA-4.0 was the highest and exceeded the activity of EA-0.8 and a commercial apple pectin by 2 and 39 times (IC50—0.050, 0.109 and 1.961 mg/mL), respectively. Pectins EA-4.0 and EA-0.8 were found to possess superoxide radical scavenging activity, with IC50s equal to 0.27 and 0.97 mg/mL, respectively. Correlation analysis of the composition and activity of 32 polysaccharide fractions obtained by enzyme hydrolysis and anionic exchange chromatography revealed that the antioxidant capacity of fireweed pectins is mainly due to phenolics and is partially associated with xylogalacturonan chains. The data obtained demonstrate that pectic polysaccharides appeared to be bioactive components of fireweed leaves with high antioxidant activity, which depend on pH at their extraction.

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Section: Resultsmentioning

confidence: 99%

Isolation, Chemical Characterization and Antioxidant Activity of Pectic Polysaccharides of Fireweed (Epilobium angustifolium L.)

Popov¹,

Смирнов²,

Kvashninova³

et al. 2021

Molecules

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“…It could trigger lipid peroxidation in the body. Therefore, the antioxidant activity of compounds could be evaluated by scavenging superoxide radicals in vitro [34]. As shown in Figure 4C, the superoxide radical scavenging was the strongest at 2000 µg/mL, which was 64.87% ± 2.63%, and the IC 50 value was 684.53 ± 8.39 µg/mL.…”

Section: In Vitro Antioxidant Activitymentioning

confidence: 99%

“…The antioxidant activity of MHP extracted using UAATPS showed a dose-dependent relationship as its antioxidant capacity increased with the increase in MHP concentration. Compared with polysaccharides from wheat bran, dandelion roots and Porphyra haitanensis, MHP has a significant antioxidant activity [33][34][35]. It is therefore a source of active compounds that might be used as potential antioxidant.…”

Section: In Vitro Antioxidant Activitymentioning

confidence: 99%

Ultrasonic-Assisted Aqueous Two-Phase Extraction and Properties of Water-Soluble Polysaccharides from Malus hupehensis

Xue

Xiao

et al. 2021

Molecules

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Malus hupehensis (M. hupehensis), an edible and medicinal plant with significant antioxidant and hypoglycemic activity, has been applied to new resource foods. However, the structural characterization and biological effects of its polysaccharides (MHP) are less known. The optimum extraction parameters to achieve the highest extraction efficiency (47.63%), the yield (1.68%) and purity of MHP (89.6%) by ultrasonic-assisted aqueous two-phase system (ATPS) were obtained under the liquid-to-solid ratio of 23 g/mL, ultrasonic power of 65 W, and ultrasonic time of 33 min. According to the analysis results, MHP was composed of Man, GlcA, Rha, GalA, Glc, Gal, Xyl, Ara, and Fuc, in which Ara and Gal were the main components, and the content of GlcA was the lowest. In in vitro activity analysis, MHP showed a significant antioxidant capacity, and an inhibition activity of α-glucosidase and the advanced glycation end products (AGEs) formation in the BSA/Glc reaction model. MHP interacted with α-glucosidase and changed the internal microenvironment of the enzyme, and inhibited the AGEs formation, which provides more evidence for the antihyperglycemic mechanism of MHP. The results suggest that ATPS is an efficient and environmentally friendly solvent system, and M. hupehensis has broad application prospects in functional foods, healthcare products, and pharmaceuticals.

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“…VC was used as a positive control. The hydroxyl radical scavenging rate, which was defined as K (%) = [ A 2 − ( A 1 − A 3)]/ A 2 × 100, was calculated [ 27 ].…”

Section: Methodsmentioning

confidence: 99%

Characterization, Antioxidant and Antitumor Activities of Oligosaccharides Isolated from Evodia lepta (Spreng) Merr. by Different Extraction Methods

et al. 2021

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Evodia lepta (E. lepta) is a traditional Chinese herbal medicine with various biological activities. One of the active components of this widely used medicinal plant is believed to be an oligosaccharide. The extraction yields, structural characteristics, antioxidant, and antitumor activities of four oligosaccharide extracts obtained by hot water extraction (HEO), ultrasound-assisted extraction (UEO), enzyme-assisted (EEO), and microwave-assisted extraction (MEO) were investigated. Matrix-assisted laser desorption/ionization-time of flight-mass spectrometry (MALDI-TOF-MS), X-ray diffraction (XRD), and Scanning electron microscopy (SEM) results indicated that the extraction methods had a difference on the molecular mass distribution, structure, and morphology of the EOs. In addition, HEO and MEO showed strong antioxidant activities, which might be related to their uronic acid and protein contents. More interestingly, MEO was more active toward MDA-MB-231 cells compared to other cells, and cell growth inhibition was proposed to occur through apoptosis. Overall, microwave-assisted extraction is a promising technique for the extraction of high quality EO.

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Characterization, antioxidant and immunomodulatory effects of selenized polysaccharides from dandelion roots

Cited by 100 publications

References 46 publications

Isolation, Chemical Characterization and Antioxidant Activity of Pectic Polysaccharides of Fireweed (Epilobium angustifolium L.)

Isolation, Chemical Characterization and Antioxidant Activity of Pectic Polysaccharides of Fireweed (Epilobium angustifolium L.)

Ultrasonic-Assisted Aqueous Two-Phase Extraction and Properties of Water-Soluble Polysaccharides from Malus hupehensis

Characterization, Antioxidant and Antitumor Activities of Oligosaccharides Isolated from Evodia lepta (Spreng) Merr. by Different Extraction Methods

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