Characterization by Multimodality Imaging of a Large Animal Model of Ischemic Dilated Cardiomyopathy With Translational Implications

Milla, J Martinez; Galán‐Arriola, Carlos; González, Manuel Lobo; Carnero, Manuel; Cobiella, Francisco Javier; Castro, Jesús Mateo de; Vilchez, Jean Paul; Salinas, Belén; Cussó, Lorena; López, Gonzalo Javier; Fuster, Valentı́n; Ibáñez, Borja

doi:10.1016/s0735-1097(19)31367-1

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“…Another possibility is the use of implanted devices that gradually constrict a coronary artery. A surgical option is the ameroid constrictor, which is wrapped around a coronary artery, and expands gradually as it absorbs water (34–37, 43). This is also often combined with ligating a distal part of the coronary artery.…”

Section: Myocardial Ischemic Models Of Hfrefmentioning

confidence: 99%

Large Animal Models of Heart Failure With Reduced Ejection Fraction (HFrEF)

Spannbauer

Traxler

Zlabinger

et al. 2019

Front. Cardiovasc. Med.

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Heart failure with reduced ejection fraction (HFrEF) is defined by an ejection fraction (EF) below 40%. Many distinct disease processes culminate in HFrEF, among them acute and chronic ischemia, pressure overload, volume overload, cytotoxic medication, and arrhythmia. To study these different etiologies the development of accurate animal models is vital. While small animal models are generally cheaper, allow for larger sample sizes and offer a greater variety of transgenic models, they have important limitations in the context of HFrEF research. Small mammals have much higher heart rates and distinct ion channels. They also have much higher basal metabolic rates and their physiology in many ways does not reflect that of humans. The size of their organs also puts practical constraints on experiments. Therefore, large animal models have been developed to accurately simulate human HFrEF. This review aims to give a short overview of the currently established large animal models of HFrEF. The main animal models discussed are dogs, pigs, and sheep. Furthermore, multiple approaches for modeling the different etiologies of HF are discussed, namely models of acute and chronic ischemia, pressure overload, volume overload as well as cytotoxic, and tachycardic pacing approaches.

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Section: Myocardial Ischemic Models Of Hfrefmentioning

confidence: 99%