Characterization, in vitro bioactivity and biological studies of sol-gel synthesized SrO substituted 58S bioactive glass

Moghanian, Amirhossein; Firoozi, Sadegh; Tahriri, Mohammadreza

doi:10.1016/j.ceramint.2017.08.004

Cited by 67 publications

(53 citation statements)

References 62 publications

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“…The outcome was more pronounced against S. aureus. It has been reported that Sr-BGs antibacterial activity could be a result of the higher concentration of Ca, P and Sr ions being released in the simulated body fluid (SBF) solutions and the higher pH values compared to the BG samples [42]. In a study by Liu et al, strontium-substituted BGs significantly inhibited the growth of sub-gingival bacteria depending on the ratio of strontium in the glasses [43].…”

Section: Discussionmentioning

confidence: 99%

“…Previously, antibacterial test results have shown that the strontium substituted 58S BG could exhibit the antibacterial effect against methicillin-resistant staphylococcus aureus (MRSA) bacteria which are resistant to methicillin and other associated antibiotics of the penicillin class. Bacterial activities ,including growth and reproduction, cell wall synthesis, cell metabolism as well as chromosomal replication can be inhibited by the release of Sr 2+ ions, as well [42,[44][45][46].…”

Section: Discussionmentioning

confidence: 99%

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Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

Baheiraei

Eyni

Bakhshi

et al. 2020

Preprint

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Background Bioactive glasses (BGs) have attracted added attention in the structure of the scaffolds for bone repair applications. Different metal ions could be doped in BGs to induce specific biological responses. Among these ions, strontium (Sr) is considered as an effective and safe doping element with promising effects on bone formation and regeneration. Methods In this experiment, we evaluated the antibacterial activities of the gelatin-BG (Gel-BG) and Gel-BG/Sr scaffolds in vitro. The osteogenic properties of the prepared scaffolds were also assessed in rabbit calvarial bone defects for 12 weeks. Alizarin Red, Hematoxylin & Eosin (H&E) and Masson’s Trichrome staining were performed to assess bone regeneration and the obtained results were compared with those without Sr. Also, histomorphometric data were obtained to evaluate the new bone, residual graft, and connective tissue. Results Both scaffolds showed in vivo bone formation during 12 weeks with the newly formed bone area in Gel-BG/Sr scaffold was higher than that in Gel-BG scaffolds after the whole period. Based on the histological results, Gel-BG/Sr exhibited acceleration of early-stage bone formation in vivo. The results of antibacterial investigation showed that although both Gel-BG/Sr and Gel-BG effectively inhibited the growth of Escherichia coli (E. coli) but, only Gel-BG/Sr structure could lead to a 3 log reduction in Staphylococcus aureus (S. aureus). Conclusions: Our results confirmed that Sr doped BG is a favorable candidate for bone tissue engineering with superior antibacterial activity and bone regeneration capacity compared with similar counterparts having no Sr ion.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

Baheiraei

Eyni

Bakhshi

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…The outcome was more pronounced against S. aureus. It has been reported that Sr-BGs antibacterial activity could be a result of the higher concentration of Ca, P and Sr ions being released in the simulated body uid (SBF) solutions and the higher pH values compared to the BG samples [52]. In a study by Liu et al , strontium-substituted BGs signi cantly inhibited the growth of sub-gingival bacteria depending on the ratio of strontium in the glasses [53].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

Baheiraei

Eyni

Bakhshi

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Bioactive glasses (BGs) have attracted added attention in the structure of the scaffolds for bone repair applications. Different metal ions could be doped in BGs to induce specific biological responses. Among these ions, strontium (Sr) is considered as an effective and safe doping element with promising effects on bone formation and regeneration.Methods: In this experiment, we evaluated the antibacterial activities of the gelatin-BG (Gel-BG) and Gel-BG/Sr scaffolds in vitro. The osteogenic properties of the prepared scaffolds were also assessed in rabbit calvarial bone defects for 12 weeks. Alizarin Red, Hematoxylin & Eosin (H&E) and Masson’s Trichrome staining were performed to assess bone regeneration and the obtained results were compared with those without Sr. Also, histomorphometric data were obtained to evaluate the new bone, residual graft, and connective tissue.Results: Both scaffolds showed in vivo bone formation during 12 weeks with the newly formed bone area in Gel-BG/Sr scaffold was higher than that in Gel-BG scaffolds after the whole period. Based on the histological results, Gel-BG/Sr exhibited acceleration of early-stage bone formation in vivo. The results of antibacterial investigation showed that although both Gel-BG/Sr and Gel-BG effectively inhibited the growth of Escherichia coli (E. coli) but, only Gel-BG/Sr structure could lead to a 3 log reduction in Staphylococcus aureus (S. aureus). Conclusions: Our results confirmed that Sr doped BG is a favorable candidate for bone tissue engineering with superior antibacterial activity and bone regeneration capacity compared with similar counterparts having no Sr ion.

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“…The incorporation of elemental additives such as alkali, alkaline earth, transition and posttransition metals enhances BGs performance and introduces osteoconductivity, angiogenicity and antibacterial properties . Magnesium (Mg) is the fourth most abundant metal cation in the human body and the second most common intracellular cation and approximately 50%–60% of Mg total content is stored in the skeleton .…”

Section: Introductionmentioning

confidence: 99%

Novel antibacterial Cu/Mg‐substituted 58S‐bioglass: Synthesis, characterization and investigation of in vitro bioactivity

Moghanian

Ghorbanoghli

Kazem‐Rostami

et al. 2019

Int J of Appl Glass Sci

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In this study, six sol‐gel copper/magnesium substituted derivatives of 58S‐BG, that is, a mol% series of 60SiO2–4P2O5–5CuO–(31–x) CaO/xMgO (where x = 0, 1, 3, 5, 8, and 10), were synthesized as new multifunctional bioactive glasses (BGs). Afterwards, the effect of MgO/CaO substitution on the in vitro formation of nanohydroxyapatite (HA), osteoblast‐like cell responses, and bioactive glasses antibacterial performance were studied. X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) results revealed that Cu‐substituted 58S‐BG consisting of 5 mol% MgO (BG‐5/5) had capability of the formation of HA on its surface while, Cu‐substituted 58S‐BGs consisting 8 mol% and 10 mol% MgO (BG‐5/8 and BG‐5/10) displayed lower bioactivity. The In vitro investigations proved that the highest values of both differentiation and proliferation of MC3T3‐E1 cells can be obtained from a 5 mol% MgO substituted BG. Furthermore, these novel Cu/Mg‐substituted 58S‐BGs displayed antibacterial effect against methicillin‐resistant staphylococcus aureus bacteria. Taken together, the results suggest the equally substituted BG‐5/5 (ie., the one consists of 5 mol% of both CuO and MgO) as a promising candidate for bone tissue engineering, among all newly designed BGs in this work, owing to its desirable cell proliferation, ALP activity, and antibacterial properties.

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Characterization, in vitro bioactivity and biological studies of sol-gel synthesized SrO substituted 58S bioactive glass

Cited by 67 publications

References 62 publications

Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

Novel antibacterial Cu/Mg‐substituted 58S‐bioglass: Synthesis, characterization and investigation of in vitro bioactivity

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