Characterization of a murine model of cardiorenal syndrome type 1 by high-resolution Doppler sonography

Paterini, Paola; Cecchetto, L.; Brocco, Silvia; Bolognesi, Massimo; Sodhi, Komal; Abraham, Nader G.; Sacerdoti, David

doi:10.1007/s40477-014-0129-y

Cited by 7 publications

(8 citation statements)

References 28 publications

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“…HO-1 induction reduces postischemic pathological cardiac remodeling and, in mice with advanced heart failure and CRS, improves cardiac function and renal vasoconstriction. This renal vasoconstriction was demonstrated in a murine model of type 1 CRS, secondary to postischemic changes of LAD ligation [ 134 ].…”

Section: Cardiorenal Syndrome and Ho-1mentioning

confidence: 99%

OX-HDL: A Starring Role in Cardiorenal Syndrome and the Effects of Heme Oxygenase-1 Intervention

et al. 2020

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In this review, we will evaluate how high-density lipoprotein (HDL) and the reverse cholesterol transport (RCT) pathway are critical for proper cardiovascular–renal physiology. We will begin by reviewing the basic concepts of HDL cholesterol synthesis and pathway regulation, followed by cardiorenal syndrome (CRS) pathophysiology. After explaining how the HDL and RCT pathways become dysfunctional through oxidative processes, we will elaborate on the potential role of HDL dysfunction in CRS. We will then present findings on how HDL function and the inducible antioxidant gene heme oxygenase-1 (HO-1) are interconnected and how induction of HO-1 is protective against HDL dysfunction and important for the proper functioning of the cardiovascular–renal system. This will substantiate the proposal of HO-1 as a novel therapeutic target to prevent HDL dysfunction and, consequently, cardiovascular disease, renal dysfunction, and the onset of CRS.

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Section: Cardiorenal Syndrome and Ho-1mentioning

confidence: 99%

OX-HDL: A Starring Role in Cardiorenal Syndrome and the Effects of Heme Oxygenase-1 Intervention

et al. 2020

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“…24 In many patients, venous congestion, more so than arterial perfusion pressure, affects renal blood flow and therefore worsens renal function. Furthermore, renal vasoconstriction also plays a hemodynamic role in CRS type 1; this has been demonstrated by Pesce et al 25 through a mouse model where renal dysfunction was induced by coronary artery ligation.…”

Section: Hemodynamic Parameters On Cardiorenal Subtypesmentioning

confidence: 81%

“…44,45 Renal arterial RI depends on parenchymal abnormalities, such as glomerulosclerosis, tubular fibrosis, tubule-interstitial lesions, and vascular abnormalities, such as renal artery atherosclerosis and renal venous congestion. 46,47 Pesce et al 25 propose to measure renal vasoconstriction by the pulsatility index (PI) through echo-Doppler as a noninvasive marker of CRS type 1 in mice, thus introducing new perspectives for the evaluation and management of this CRS subtype. In this study, renal interlobar arteries were identified using color Doppler to measure the arterial flow in the renal cortex.…”

Section: Hemodynamic Parameters On Cardiorenal Subtypesmentioning

confidence: 99%

“…This was used to measure peak velocity (Vmax), end-diastolic velocity (Vmin), and mean velocity (VM), as well as calculate the PI where PI = (Vmax − Vmin)/Vmean. 25 Pulsatility index has been found to correlate with renal vascular resistance, filtration fraction, and effective renal plasma flow in chronic renal failure. 12…”

Section: Hemodynamic Parameters On Cardiorenal Subtypesmentioning

confidence: 99%

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Cardiorenal Syndrome, Hemodynamics, and Noninvasive Evaluation

Cortesi

Ibrahim

Rivera

et al. 2017

Clinical Medicine Insights: Therapeutics

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Cardiorenal syndrome is a group of disorders resulting from the pathological interaction between the heart and the kidneys. The most accepted classification of cardiorenal syndrome differentiates the types based on the temporal sequence of organ involvement. Although many mechanisms seem to be involved in the pathogenesis, cardiac hemodynamic changes are still considered one of the major parameters that affect the cross talk between these organs. As heart failure and chronic kidney disease reach endemic proportions, the necessity to understand the pathophysiology, hemodynamics, and effective therapy of cardiorenal syndrome becomes fundamental. The aim of this review is to identify and explain the hemodynamic changes behind the syndrome and evaluate potential noninvasive methods that can help develop a practical tool for managing the cardiorenal patient.

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“…Other papers report aortic stiffness of db/db mice [11,12], but all these studies are based on ex vivo analysis of explanted vessels. On the other hand, information on renal and hepatic status in this animal model are scanty: renal dysfunction has been assessed by ultrasound in a murine model of myocardial infarction [13] and obesity [14], but no in vivo data are available on the db/db mice; furthermore, an assessment of the degree of steatosis evaluated in vivo by ultrasound in the db/db model has never been performed to the best of our knowledge.…”

Section: Introductionmentioning

confidence: 99%

P79 Ultrasonographic Characterization of the Db/Db Mouse, an Animal Model of Metabolic Abnormalities

Lascio¹,

Rossi²,

Kusmic³

et al. 2017

ARTRES

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The availability of an animal model able to reliably mirror organ damage occurring in metabolic diseases is an urgent need. These models, mostly rodents, have not been fully characterized in terms of cardiovascular, renal, and hepatic ultrasound parameters, and only sparse values can be found in literature. Aim of this paper is to provide a detailed, noninvasive description of the heart, vessels, liver, and kidneys of the db/db mouse by ultrasound imaging. Sixteen wild type and thirty-four db/db male mice (11-week-old) were studied. State-of-the-art ultrasound technology was used to acquire images of cardiovascular, renal, and hepatic districts. A set of parameters describing function of the selected organs was evaluated. db/db mice are characterized by systolic and diastolic dysfunction, confirmed by strain analysis. Abdominal aortic and carotid stiffness do not seem to be increased in diabetic rodents; furthermore, they are characterized by a smaller mean diameter for both vessels. Renal microcirculation is significantly compromised, while liver steatosis is only slightly higher in db/db mice than in controls. We offer here for the first time an in vivo detailed ultrasonographic characterization of the db/db mouse, providing a useful tool for a thoughtful choice of the right rodent model for any experimental design.

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Characterization of a murine model of cardiorenal syndrome type 1 by high-resolution Doppler sonography

Abstract: The mice model of LAD is a good model of CRS-1 evaluable by Doppler sonography and characterized by renal vasoconstriction due to the activation of the renin-angiotensin system secondary to heart failure.

Cited by 7 publications

References 28 publications

OX-HDL: A Starring Role in Cardiorenal Syndrome and the Effects of Heme Oxygenase-1 Intervention

OX-HDL: A Starring Role in Cardiorenal Syndrome and the Effects of Heme Oxygenase-1 Intervention

Cardiorenal Syndrome, Hemodynamics, and Noninvasive Evaluation

P79 Ultrasonographic Characterization of the Db/Db Mouse, an Animal Model of Metabolic Abnormalities

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