Characterization of a Novel Dioxomolybdenum Complex by Cyclic Voltammetry

Abstract

Metalloenzymes that carry a pterin-based molybdenum cofactor in their center catalyze numerous reactions in the human body and play a crucial role in its metabolism. Specifically, these enzymes promote redox reactions and oxygen transport in the body. Their absence may cause many problems leading to disability or even death in early childhood. Therefore, model compounds need to be synthesized and analyzed to investigate the reactivity, redox potential, and geometry of these cofactors. This study focused on electrode processes and determined the redox potentials of the new bis-(4-mercapto-5-(p-tolyl)-3H-1,2-dithiole-3-thione)-dioxomolybdenum complex by cyclic voltammetry. The 4-mercapto-5-(p-tolyl)-3H-1,2-dithiole-3-thione ligand underwent irreversible oxidation and reduction at thiol and thione functional groups. The new dioxomolybdenum complex showed a quasi-reversible two-stage electrode process.

Cyclic Voltammetry and Its Applications

“…Our contribution has shown the use of CV to support the results from X-ray crystallography to explain the behavior of copperthiourea-halide complexes [20]. Redox potential and reversibility obtained by CV have been proved to be useful in studying metalloenzymes with cofactor of molybdenum complexes as a model to describe its physiological role [21]. The characterizations of metal complexes have also been indicated to help investigate the catalytic activities Cyclic Voltammetry and Its Applications DOI: http://dx.doi.org/10.5772/intechopen.83451 of complexes for the removal of toxic phenolic substances, especially dyes [22].…”

Advanced Electroanalysis for Electrosynthesis

“…This research specifically focuses on elucidating the behavior of copper-thiourea-halide complexes. Besides, the utilization of CV has demonstrated the utility of redox potential and reversibility in investigating metalloenzymes with molybdenum cofactor complexes as a model for elucidating their physiological function …”

“…Besides, the utilization of CV has demonstrated the utility of redox potential and reversibility in investigating metalloenzymes with molybdenum cofactor complexes as a model for elucidating their physiological function. 131 CV can also serve as a method to track the behavior of activated iridium oxide film microelectrodes. This can be achieved by adjusting the scan rate during both the fabrication and animal implantation processes.…”

Recent Progress of the Practical Applications of the Platinum Nanoparticle-Based Electrochemistry Biosensors

“…The detection of glutamate levels in the extracellular space of brain tissues is therefore essential in the evaluation of psychiatric disorders. The conventional methods for the detection of glutamic acids, such as chromatography, fluorescence, spectrophotometry, and electrochemiluminescence, are not only time-consuming and laborious, but also require specialized skills (Sanchez and Gallardo, 1992 ; Chovin et al, 2004 ; Acebal et al, 2008 ; Shah et al, 2008 ; Knittl et al, 2015 ). The use of the electrochemical method for glutamate detection is simple, low-cost, and gives real-time results (Barman et al, 2017 ).…”