Characterization of a Protease Responsible for Truncated Actin Increase in Neutrophils of Patients with Behcet's Disease.

Yamashita, Shinji; Suzuki, Akiko; Yanagita, Tamiko; Hirohata, Shunsei; Toyoshima, Satoshi

doi:10.1248/bpb.24.119

Cited by 6 publications

(4 citation statements)

References 13 publications

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“…Immune complexes may also contribute to RAS 47. Inflammation materials such as polymorphonuclear leukocytes (PMNs) are activated in RAS,68, 69, 70, 71 and PMNs exhibit increased motility and enhanced adhesion to endothelial cells in vitro 72, 73. Endothelial dysfunction is typical in patients with RAS and BD 74, 75, 76, 77.…”

Section: Discussionmentioning

confidence: 99%

Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case‐control frequency‐matched study

et al. 2018

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BackgroundRecurrent aphthous stomatitis (RAS) is considered a prophase symptom in patients with specific cancers. This study assessed the association between RAS and subsequent onset of cancer based on a nationwide population‐based database in Taiwan.Materials and MethodsWe selected study participants from the National Health Insurance Research Database from January 2000 to December 2008. Patients in the non‐RAS cohort were matched to case study patients at a 1:1 ratio through frequency matching. All participants were followed up for at least 5 years, and those who received cancer diagnoses during follow‐up were identified.ResultsAmong 52 307 patients with and 52 304 patients without RAS, the combined hazard ratio (HR) of all subsequent cancer cases was 1.3 (95% confidence interval [CI]: 1.25‐1.35, P = 0). RAS diagnosis was associated with risk for cancers of the head and neck (aHR = 2, 95% CI: 1.8‐2.3), colon (aHR = 1.2, 95% CI: 1.1‐1.4), liver (aHR = 1.1, 95% CI: 1‐1.3), pancreas (aHR = 1.4, 95% CI: 1.1‐1.7), skin (aHR = 1.4, 95% CI: 1.2‐1.7), breast (aHR = 1.2, 95% CI: 1.1‐1.4), and prostate (aHR = 1.5, 95% CI: 1.3‐1.8), as well as hematologic cancers (aHR = 1.6, 95% CI: 1.3‐1.9). A higher risk was observed for male patients (aHR = 1.35, 95% CI: 1.28‐1.42) than for female patients (aHR = 1.25, 95% CI: 1.18‐1.31) with RAS.Conclusions RAS was associated with specific cancers. Susceptible RAS patients should be screened for specific cancers.

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Section: Discussionmentioning

confidence: 99%

Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case‐control frequency‐matched study

et al. 2018

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“…It is undoubted that 42-merP is further digested with various proteases present in the plasma. 6) However, 42-merP was detected in the plasma of patients with Behçet's disease as shown in Fig. 1.…”

Section: Detection Of 42-merp In Plasmamentioning

confidence: 94%

“…Actin and truncated actin with an N-terminus of Met-44 were detected by SDS/PAGE analysis as reported previously. 6) Polymerization of actin after digestion was induced by incubation at 25°C for 60 min in 0.1 M KCl solution containing 0.2 mM MgCl 2 . Then, polymerized actin was sedimented by centrifugation at 198000ϫg for 60 min.…”

Section: )mentioning

confidence: 99%

“…Furthermore, we have found that polymorphonuclear (PMN)-elastase specifically cleaves actin at the site between Val-43 and Met-44 in neutrophils of patients with Behçet's disease. 6) PMN-elastase is an enzyme localized in the azurophil granules of neutrophils and is thought to take part in the degradation of materials that have been engulfed by phagocytes. 7,8) Chymotrypsin, 9) subtilisin 10) and protease from E. coli 11) have been reported to cleave actin at sites that are different from that of PMN-elastase.…”

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