Characterization of a sulfated galactoglucan from Antrodia cinnamomea and its anticancer mechanism via TGFβ/FAK/Slug axis suppression

Lu, Mei-Kuang; Lin, Tsai-Yun; Hu, Chun Hao; Chao, Chi Hsein; Chang, Chia Chuan; Hsu, Hsien Yeh

doi:10.1016/j.carbpol.2017.02.104

Cited by 27 publications

(3 citation statements)

References 46 publications

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“…Many studies had demonstrated that AC extract exhibits anticancer activity by reducing cancer cell proliferation and tumor growth. A sulfated galactoglucan isolated from AC and ethanol extract of AC fruiting bodies suppressed cancer cell migration by inhibiting the signaling pathways of metalloproteinases, ERK, JNK, p38, PI3K/Akt, and TGF/FAK/Slug in human lung cancer cells [20,36,37]. Te ingredients isolated from AC, including 4-acetylantroquinonol B, antrocin, and antrodan, have been demonstrated to arrest cell proliferation and suppress cell migration and invasion of hepatocellular carcinoma, lung carcinoma, bladder cancer, and breast cancer cells [32,[38][39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Antrodia cinnamomea Extract Attenuates Cisplatin-Induced Muscle Atrophy, Apoptosis, and Cell Growth Suppression

Liang,

Kuo,

et al. 2023

Journal of Food Biochemistry

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Antrodia cinnamomea (AC), a potential medicinal fungus which possesses anti-inflammatory and anticancer activities, has been previously reported to be able to ameliorate muscle wasting in cisplatin-treated lung tumor-bearing mice via AC extract. However, whether AC extract modulates muscle cell differentiation, apoptosis, and cell cycle progression remains unclear. Here, we show that the ethanol extract of AC (EEAC) significantly restored cisplatin-reduced quadricep mass in mice. EEAC attenuated cisplatin/gemcitabine (C/G)-suppressed elongated myotube formation, which is differentiated from C2C12 cells. Moreover, EEAC synergized with C/G to inhibit cell growth of LLC1 cells, whereas EEAC attenuated C/G-reduced proliferation of C2C12 cells. Although EEAC protected C/G-induced apoptosis of both LLC1 and C2C12, EEAC suppressed cyclin D expression in LLC1 while partially restoring C/G-reduced cyclin D level in C2C12 cells. Finally, as p 53 and p 21 participate in inducing skeletal muscle atrophy, we found that C/G induced p 53 and p 21 expression in C2C12 cells but with its effect significantly attenuated by EEAC. Our findings indicate that AC extract is a potential natural agent for attenuating cisplatin-induced muscle atrophy. Practical Applications. Muscle atrophy is one of the major side effects caused by chemotherapy. In addition to inducing cell death, chemotherapeutic agents inhibit cell growth of both cancer and normal cells as well. Our current findings indicated that AC extract attenuates cisplatin-induced muscle wasting and apoptosis of C2C12 cells. AC extract is a potential dietary supplement used for ameliorating chemotherapy-induced muscle atrophy.

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Section: Discussionmentioning

confidence: 99%

Antrodia cinnamomea Extract Attenuates Cisplatin-Induced Muscle Atrophy, Apoptosis, and Cell Growth Suppression

Liang,

Kuo,

et al. 2023

Journal of Food Biochemistry

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“…B86-III inhibited the expression and migration of Slug by downregulating the TGFR I protein and inhibiting the phosphorylation of FAK. Finally, the activity of H1975 lung cancer cells was inhibited (Lu et al, 2017b). In addition, the polysaccharides isolated from A. cinnamomea mycelium (AC-PS) significantly inhibited the proliferation of leukemia U937 cells by activating mononuclear cells (MNCs) (Liu et al, 2004).…”

Section: Anticancer Activity Of Apssmentioning

confidence: 99%

“…Moreover, the authors were the first to isolate and identify a 1,4-D-galactoman (B86-III) containing 1,6-branched chains from A. cinnamomea. TGFR and its downstream signals, focal adhesion kinase (FAK), and Slug were involved in the development of lung tumors (Lu et al, 2017b). B86-III inhibited the expression and migration of Slug by downregulating the TGFR I protein and inhibiting the phosphorylation of FAK.…”

Section: Anticancer Activity Of Apssmentioning

confidence: 99%

Extraction, isolation, identification, and bioactivity of polysaccharides from Antrodia cinnamomea

Dai,

Liu,

et al. 2023

Qual. Assur. Saf. Crops Foods

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Antrodia (A) cinnamomea is a precious edible and medicinal mushroom and has attracted attention because of its rare resources and unique bioactivities. The bioactive compounds from the fruit body, mycelium, and fermentation broth of A. cinnamomea include triterpenoids, polysaccharides, antroquinonols, benzenoids, and succinic and maleic acid derivatives. Among these, polysaccharides are very important and are high-content bioactive compounds. The A. cinnamomea polysaccharides (APSs) present numerous biological activities, such as antiviral, anticancer, anti-inflammatory, antivascular, immunoregulation, antioxidant, and nerve protection. However, only few studies have focused only on APSs so far. Therefore, the cultivation methods, extraction, isolation, composition, structure, biological activity, and application of APSs are summarized in this review to provide a comprehensive and convenient reference for further research and development on APSs.

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Extraction, characterization, antioxidant and α-amylase inhibitory activities of (1 → 3)(1 → 6)-β-D-glucogalactan from Aspergillus niger ATCC 1004

et al. 2023

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Characterization of a sulfated galactoglucan from Antrodia cinnamomea and its anticancer mechanism via TGFβ/FAK/Slug axis suppression

Cited by 27 publications

References 46 publications

Antrodia cinnamomea Extract Attenuates Cisplatin-Induced Muscle Atrophy, Apoptosis, and Cell Growth Suppression

Antrodia cinnamomea Extract Attenuates Cisplatin-Induced Muscle Atrophy, Apoptosis, and Cell Growth Suppression

Extraction, isolation, identification, and bioactivity of polysaccharides from Antrodia cinnamomea

Extraction, characterization, antioxidant and α-amylase inhibitory activities of (1 → 3)(1 → 6)-β-D-glucogalactan from Aspergillus niger ATCC 1004

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