Characterization of aberrant FHIT transcripts in gastric adenocarcinomas

Fhit Expression Protects Against HER2-Driven Breast tumor Development: Unraveling the Molecular Interconnections

“…[18][19][20][21][22] Similar findings have been reported for cervical cancer, [23][24][25][26][27][28] and oral carcinomas. 29 By contrast, the gap between the percentages of Fhit protein loss versus Fhit aberrant transcripts is wider in breast cancers.…”

Human FEN-1 can process the 5'-flap DNA of CTG/CAG triplet repeat derived from human genetic diseases by length and sequence dependent manner

“…Oligonucleotides were synthesized on an Applied Biosystem (ABI) DNA synthesizer and further purified on a 10% 0.5X TBE Urea-gel by the method indicated in Sambrook et al (Sambrook, 1989;Kim et al, 2000;Lee et al, 2001). The sequences of the oligonucleotides are indicated below.…”

Fragile histidine triad protein: structure, function, and its association with tumorogenesis

“…In cancer cells, these events are often associated with deletions directly within the FRA3B region, centering on exon 5 of FHIT. A high frequency of heterozygous and homozygous deletions with breakpoints within the fragile site region of FHIT has been detected in large number of cancers and cancer cell lines (Virgilio et al 1996;Lee et al 2001;Holschneider et al 2005;Cao et al 2006;Smith et al 2007). Corbin et al (2002) showed multiple, variable deletions in FRA3B, even in cells derived from the same tumor, suggesting ongoing instability in the region.…”