Characterization of acid‐signaling in rat vagal pulmonary sensory neurons

Gu, Qihai; Lee, Lu‐Yuan

doi:10.1096/fasebj.20.4.a787

Cited by 1 publication

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“…TRPV1) are expressed in sensory neurons innervating the gastrointestinal tract [17], but oesophageal, intestinal, and lung epithelial cells also express ASICs, potentially contributing to acidinduced secretions, transport, and inflammation [68][69][70]. The gastrointestinal expression of ASICs may reflect a chemosensory role, like that mediated by ASICs in neurons innervating the lungs and skin of mammals [71,72]. Similar functions are suggested by ASIC expression in the peripheral nervous system of other chordates and Ambulacraria ( [24,73], Fig 5).…”

Section: Peripheral and Central Roles For Asicsmentioning

confidence: 99%

Peripheral and central employment of acid-sensing ion channels during early bilaterian evolution

Martí-Solans

Børve

Bump

et al. 2022

Preprint

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Acid-sensing ion channels (ASICs) are membrane proteins that endow vertebrate neurons with fast excitatory responses to decreases in extracellular pH. Although previous studies suggest that ASICs are found in certain invertebrates, the lineage in which ASICs emerged and the functional role of ASICs beyond the vertebrates is unknown. We reconstructed ASIC evolution by surveying metazoan ASICs and performing a phylogenetic analysis, which suggests that ASICs evolved in an early bilaterian. This was supported by electrophysiological measurements of proton-gated currents at heterologous channels from diverse bilaterians. This also revealed substantial variation in biophysical properties of broadly related ASICs, with selective sodium/potassium ion permeability ranging from 3- to 36-fold and half-maximal activating pH from 4.2 to 8.1. Furthermore, we studied the expression of ASICs in species outside the vertebrates and found expression in the central nervous system of certain bilaterian lineages but in the periphery, including nervous system, digestive system, and motile ciliated epithelia, of most lineages. The loss of such epithelial cells in Ecdysozoa might explain the loss of ASICs from this major animal lineage. Our results suggest that ASICs emerged in an early bilaterian, and expression in the central nervous system was accompanied or even pre-dated by expression in the periphery.

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