Characterization of Aedes albopictus akirin for the control of mosquito and sand fly infestations

Vaccination with cyclin-dependent kinase tick antigen confers protection against Ixodes infestation

“…Experimental vaccines with these antigens demonstrated their potential to control R. microplus and Ixodes scapularis infestations. Antibody response was correlated with a low tick weight, poor oviposition rates, and reduced egg fertility (Almazan et al, 2005;Moreno-Cid et al, 2010;de la Fuente and Merino, 2013). In this report, we hypothesized that blocking CDKs through immunization interferes with tick fertility, since alterations in cellular division may affect egg/embryo development.…”

Prospects for vaccination against the ticks of pets and the potential impact on pathogen transmission

“…The hypothesis behind vaccine action is that ectoparasites feeding on immunized hosts ingest antibodies specific for the target antigen that could reduce their levels and biological activity and/or interact with conserved epitopes in other proteins resulting in reduced feeding, developmental and reproductive performance, with a possible reduction in vector capacity (de la Fuente et al, 2006a(de la Fuente et al, , 2006bMerino et al, 2011aMerino et al, , 2011bMoreno-Cid et al, 2011Bensaci et al, 2012). Therefore, the greatest vaccine effect is in the reduction of larval infestations in subsequent generations, which results in the reduction of ectoparasite populations and thus the exposure of susceptible hosts to vector infestations and VBD (de la Fuente et al, 2007).…”

“…However, recent results have shown that it is possible to use vector protective antigens for the control of arthropod vector infestations and pathogen infection (de la Fuente andKocan, 2003, 2006;Willadsen, 2004;de la Fuente et al, 2006ade la Fuente et al, , 2006bde la Fuente et al, , 2007de la Fuente et al, , 2011Merino et al, 2011aMerino et al, , 2011bMoreno-Cid et al, 2011Bensaci et al, 2012;.…”

Akirin2 expression in response to vaccine-induced immunity in chicken

“…In mice, Akirin2 plays major roles in the Toll-like receptor (TLR), tumor necrosis factor (TNF), and interleukin (IL)-1 signalling pathways, and act in conjunction with nuclear factor kappa B (NF-κB) to induce the transcription of many immune-related genes, including the interleukin-6 (IL-6) gene (Goto et al, 2008;Tartey et al, 2014). Moreover, the recombinant Akirin2 protein can be used as a vaccine to partially protect animals against insect infestations (Galindo et al, 2009;Harrington et al, 2009;Moreno-Cid et al, 2010;de la Fuente et al, 2011;Carreón et al, 2012;Manzano-Román et al, 2012). Akirin2 plays an essential role in NF-κB activation; NF-κB is a multi-functional transcription complex that regulates the expression of many immune-response genes such as cytokines, chemokines, and microRNAs Ghosh, 2004, 2008;Bidère et al, 2009;Vallabhapurapu and Karin, 2009).…”