Characterization of amplification patterns and target genes on the short arm of chromosome 7 in early-stage lung adenocarcinoma

Abstract

Abstract. Chromosomal alterations are a predominant genomic force contributing to the development of lung adenocarcinoma (ADC). High density genomic arrays were conducted to identify critical genetic landmarks that may be important mediators in the formation or progression of early-stage ADC. In this study, the most noteworthy and consistent observation was a copy number gain on the short arm of chromosome 7, which was detected in 85.7% (12/14) of cases. Notably, three distinct regions of amplification were identified between the 7p22.3 and q11.2 regions in 28.6% (4/14) of cases; at a size of 4.1 Mbp (7p22.3-p21.1), 2.6 Mbp (7p15.2-p14.1) and 1.5 Mbp (7p12.3-p11.2). Variations of the 7p11.2 locus that encodes EGFR are known to be oncogenic. Furthermore, potential target genes were identified that were previously not assumed to be involved in the pathogenesis of ADC, including CALM1P2 (7p11.2), HOXA4, HOXA5, HOXA6, HOXA7, HOXA9, HOXA10, HOXA11 and HOXA13 (7p15.2) and LOC442586, LOC442589, LOC442282, FAM20C and LOC442651 (7p22.3). The present study determined critical regions on the 7p arm of chromosome 7, which were implicated in ADC. The pattern of rearrangements on the 7p arm may be a consequence of the high density of potential targets and the identified genes at the 7p regions may aid in the development of therapeutic targets for ADC.

Silencing of LINC00461 enhances radiosensitivity of lung adenocarcinoma cells by down‐regulating HOXA10 via microRNA‐195

“…1 Lung adenocarcinoma, presenting as epithelial cancer of glandular origin, has the highest prevalence of all types of non-small cell lung cancer (NSCLC). 2 In addition, lung adenocarcinoma accounts for 40% of lung cancer cases, accounting for over 500,000 yearly deaths worldwide. 3 Approximately 25%-30% of patients with NSCLC have contracted a localized disease because of surgical intervention for curative purposes; unfortunately, the 5-year survival rate still remains to be poor, and 40%-70% of these patients are at risk of a susceptible systemic disease with or without local relapses and could eventually die from it.…”

HOXA13 contributes to gastric carcinogenesis through DHRS2 interacting with MDM2 and confers 5‐FU resistance by a p53‐dependent pathway

“…HOXA13, a member of the homeobox gene family that encodes homeodomain‐ containing transcription factors, has been highly expressed in many human tumors . Our team first discovered HOXA13 overexpression in GC previously.…”

EGFRvIII: An Oncogene with Ambiguous Role

“…Gene encoding EGFR is located on a short arm of chromosome 7 (p11.2) and consists of 28 exons [11]. Mature EGFR protein (1186 amino acids) is formed from a precursor one (1210 amino acids) following the removal of the Nterminal part [12].…”