Characterization of anti-inflammatory effect and possible mechanism of action of <i>Tibouchina granulosa</i>

Sobrinho, Andrea P.; Minho, Alan Silva; Ferreira, Leide Lene Coelho; Martins, Gabriel R.; Boylan, Fábio; Fernandes, Patrícia Dias

doi:10.1111/jphp.12712

Cited by 14 publications

(11 citation statements)

References 28 publications

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“…Bioactive ingredients present in nutraceuticals have exhibited diverse pharmacological properties such as antioxidant, sedative, hypnotic, anti-inflammatory, immuno-modulatory and adaptogenic attributes [ 219 , 220 , 221 , 222 , 223 ]. Subsequently, these products were applied and their efficiency appraised using in vitro, in vivo, in silico, high-throughput in vitro, and omics technology-reliant assays [ 224 ]. Furthermore, various animal models have been used for in vivo, invasive, and non-invasive studies depending upon study design [ 225 ].…”

Section: Nutraceuticals’ Safety On Consumersmentioning

confidence: 99%

Nutraceuticals: Transformation of Conventional Foods into Health Promoters/Disease Preventers and Safety Considerations

et al. 2021

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Nutraceuticals are essential food constituents that provide nutritional benefits as well as medicinal effects. The benefits of these foods are due to the presence of active compounds such as carotenoids, collagen hydrolysate, and dietary fibers. Nutraceuticals have been found to positively affect cardiovascular and immune system health and have a role in infection and cancer prevention. Nutraceuticals can be categorized into different classes based on their nature and mode of action. In this review, different classifications of nutraceuticals and their potential therapeutic activity, such as anti-cancer, antioxidant, anti-inflammatory and anti-lipid activity in disease will be reviewed. Moreover, the different mechanisms of action of these products, applications, and safety upon consumers including current trends and future prospect of nutraceuticals will be included.

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Section: Nutraceuticals’ Safety On Consumersmentioning

confidence: 99%

Nutraceuticals: Transformation of Conventional Foods into Health Promoters/Disease Preventers and Safety Considerations

et al. 2021

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“…Mice were tested using the method described by Sobrinho et al, [21]. Animals were placed on a hot plate (Insight Equipment, São Paulo, Brazil) set at 55 ± 1 °C.…”

Section: Methodsmentioning

confidence: 99%

Chemistry and Pharmacology of the Kazakh Crataegus Almaatensis Pojark: An Asian Herbal Medicine

et al. 2019

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Crataegus almaatensis, an endemic ornamental plant in Kazakhstan is used in popular medicine due to its cardiotonic properties. The most studied species of the same genus are commonly found in Europe, which shows the importance of having the Kazakh species validated via its chemical and pharmacological studies. High-speed countercurrent chromatography (HSCCC) operated under optimized conditions enabled an isolation of the three main compounds from the aqueous phase of the leaves ethanol extract, further identified by nuclear magnetic resonance (NMR), as quercetin 3-O-rhamnoside (quercitrin) (4.02% of the crude extract-CECa); quercetin 3-O-β-galactoside (hyperoside) (1.82% of CECa); kaempferol 3-O-α-L-rhamnoside (afzelin) (0.94% of CECa). The CECa, the aqueous phase of the crude extract (APCa) together with the isolates were evaluated for their vascular (vascular reactivity in human internal mammary artery-HIMA), anti-nociceptive (formalin-induced liking response and hot plate) and anti-inflammatory (subcutaneous air-pouch model-SAP) activities. CECa at the concentrations of 0.014 and 0.14 mg/mL significantly increased the maximum contractility response of HIMA to noradrenaline. The APCa CR curve (0.007–0.7 mg/mL) showed an intrinsic relaxation effect of the HIMA. APCa at the dose of 100 mg/kg i.p. significantly decreased the total leukocyte count and the IL-1β release in the SAP wash.

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“…Studies of the biological potential of the family Melastomataceae have demonstrated that its species have analgesic, antioxidant, antimicrobial, anti-inflammatory activities (Vasconcelos et al, 2006;Andreo et al, 2006;Sobrinho et al, 2017;Bomfim et al, 2020). These activities may be associated with the presence of several secondary metabolites such as flavonoids, tannins, terpenes and anthocyanidins (Calderón et al, 2002;Serna and Martínez, 2015;Bomfim et al, 2020) which are synthesized by plants in response to environmental conditions and often during specific stages of their development.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical composition and biological activities of extracts from ten species of the family Melastomataceae Juss

et al. 2022

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Plants possess a renewable source of metabolites with enormous chemical structural diversity, which may have potential therapeutic relevance. Furthermore, this chemical diversity favors the possibility of finding new and different chemical constituents with antimicrobial, antioxidant and anti-tumor activities. This work analyzed preliminary phytochemical profiles and evaluated the antimicrobial, antioxidant and cytotoxic activities of hexane extracts of leaves of ten species of the family Melastomataceae. Phytochemical screening was performed using staining methods while total phenols and flavonoids were quantified by spectrophotometry. Antimicrobial activity was evaluated using the disk diffusion method. Antioxidant activity was determined by the 2,2-diphenyl-1-picrylhydrazil (DPPH) method. Toxicity was recorded using the lethality test with Artemia salina Leach (1819). Cytotoxic activity of the extracts was assessed in vitro with acute monocytic leukemia cells (THP-1). Phytochemical analysis detected the presence of tannins, terpenes, steroids, polyphenols and flavonoids and the absence of alkaloids. Clidemia capitellata (Bonpl.) D. Don had the greatest amount of polyphenols (205.95 mg/g ± 4.14) while Clidemia hirta (L.) D. Don had the highest content of total flavonoids (143.99 mg/g ± 4.18). The hexane extracts did not show antimicrobial activity nor toxicity against Artemia salina. The extract of Tibouchina francavillana Cogn. was the most active in sequestering the DPPH radical. The extracts showed cytotoxicity in THP-1 cells with the appearance of apoptotic bodies and cell death. The extracts of Miconia amoena, Clidemia sericea and Clidemia capitellata are non-toxic against Artemia salina and induce the formation of apoptotic bodies and cell death of the THP-1 lineage.

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Characterization of anti-inflammatory effect and possible mechanism of action of Tibouchina granulosa

Abstract: Taken together, our results indicate that leaves of T. granulosa present anti-inflammatory effect and can be useful in the preparation of new phytomedicines.

Cited by 14 publications

References 28 publications

Nutraceuticals: Transformation of Conventional Foods into Health Promoters/Disease Preventers and Safety Considerations

Nutraceuticals: Transformation of Conventional Foods into Health Promoters/Disease Preventers and Safety Considerations

Chemistry and Pharmacology of the Kazakh Crataegus Almaatensis Pojark: An Asian Herbal Medicine

Phytochemical composition and biological activities of extracts from ten species of the family Melastomataceae Juss

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