Characterization of bioactive compounds and ameliorative effects of Ceratonia siliqua leaf extract against CCl4 induced hepatic oxidative damage and renal failure in rats

Hsouna, Anis Ben; Saoudi, Mongi; Trigui, Mohamed; Jamoussi, Kamel; Boudawara, Tahia; Jaoua, Samir; Feki, Abdelfattah El

doi:10.1016/j.fct.2011.09.034

Cited by 78 publications

(49 citation statements)

References 27 publications

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“…4,20) Moreover, CCl 4 is a prototypical lipid peroxidant that induces early lipid peroxidation in the liver. 8) As a marker of lipid peroxidation, MDA concentration was measured in all animal groups.…”

Section: Resultsmentioning

confidence: 99%

Suppressive Effect of Kampo Formula “Juzen-taiho-to” on Carbon Tetrachloride-Induced Hepatotoxicity in Mice

Yoshioka

Fukaya

Miura

et al. 2016

Biological & Pharmaceutical Bulletin

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Section: Resultsmentioning

confidence: 99%

Suppressive Effect of Kampo Formula “Juzen-taiho-to” on Carbon Tetrachloride-Induced Hepatotoxicity in Mice

Yoshioka

Fukaya

Miura

et al. 2016

Biological & Pharmaceutical Bulletin

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“…pendulum (Kappel et al, 2008) Passiflora edulis Sims (Silva et al, 2013) Cassia fistula Linn. (Maheep, Sunil, Yogesh, Durgesh, & Kanika, 2010) Pinus koraiensis L. (Su et al, 2009) Ceratonia siliqua (Hsouna et al, 2011 Whole grapes 250 g 1 dose/day 4 weeks ORAC-PCA (Parker et al, 2007) Whole raisins 50 g of golden raisins 50 g sun driedraisins 1 dose/day 4 weeks (Parker et al, 2007) 43 …”

Section: Plant References Plant Referencesmentioning

confidence: 99%

In vivo antioxidant activity of phenolic compounds: Facts and gaps

Martins

Barros

Ferreira

2016

Trends in Food Science & Technology

271

159

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Background: Numerous diseases have been related with free radicals overproduction and oxidative stress. Botanical preparations possess a multitude of bioactive properties, including antioxidant potential, which has been mainly related with the presence of phenolic compounds. However, the mechanisms of action of these phytochemicals, in vivo effects, bioavailability and bio-efficacy still need research.Scope and Approach: The present report aims to provide a critical review on the aspects related with the in vivo antioxidant activity of phenolic extracts and compounds from plant origin.Key findings: Biological functions beyond the human metabolism were discussed, comparing in vivo vs. in vitro studies, as also focusing the conditioning factors for phenolic compounds bioavailability and bio-efficacy. Furthermore, an upcoming perspective about the use of phytochemicals as life expectancy promoters and anti-aging factors in human individuals was provided.Conclusions: Overall, and despite all of those advances, the study of the biological potential of numerous natural matrices still remains a hot topic among the scientific community. In fact, the available knowledge about the responsible phytochemicals for the biological potential, their mechanisms of action, the establishment of therapeutic and prophylactic doses, and even the occurrence of biochemical inter-relations, is considerable scarce.

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“…Several studies have suggested that one possible molecular mechanism involved in CCl 4 hepatotoxicity is disruption of the delicate oxidant/antioxidant balance, which can lead to liver injury via oxidative damage [4,22]. Moreover, CCl 4 is a prototypical lipid peroxidant that induces early lipid peroxidation in the liver [8].…”

Section: Resultsmentioning

confidence: 99%

Kampo formula “Hochu-ekki-to” suppressed carbon tetrachloride-induced hepatotoxicity in mice

Yoshioka

Fukaya

Onosaka

et al. 2016

Environ Health Prev Med

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Objective The aim of this study was to investigate whether pretreatment with the Japanese herbal medicine ''Hochuekki-to'' (TJ-41) has an ameliorative effect on carbon tetrachloride (CCl 4 )-induced hepatotoxicity through anorexia prevention. Methods Twenty-four hours before CCl 4 injection, TJ-41 or saline solution was intraperitoneally administered. Furthermore, 24 h after TJ-41 injection, mice were intraperitoneally administered 1.6 g/kg CCl 4 or olive oil. Moreover, 24 h after CCl 4 /olive oil injection, mice from each group were euthanized and bled for plasma analysis. Results Mice injected with CCl 4 exhibited severe anorexia. Moreover, CCl 4 increased the plasma levels of hepatic injury markers (i.e., alanine aminotransferase and aspartate aminotransferase) as well as lipid peroxidation and hepatic Ca levels. Pretreatment with TJ-41 recovered the CCl 4 -induced anorexia and plasma levels of the hepatic injury markers. Moreover, CCl 4 -induced lipid peroxidation and hepatic Ca levels decreased upon TJ-41 pretreatment. In addition, hepatic metallothionein levels in the TJ-41 ? CCl 4 -treated group were decreased by [50 % compared with the levels in the TJ-41-treated group, implying that metallothionein was consumed by CCl 4 -induced radicals. ConclusionOur results suggest that TJ-41 attenuates CCl 4 -induced hepatotoxicity, presumably by the induction of metallothionein, which in turn scavenges radicals induced by CCl 4 exposure.

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Characterization of bioactive compounds and ameliorative effects of Ceratonia siliqua leaf extract against CCl4 induced hepatic oxidative damage and renal failure in rats

Cited by 78 publications

References 27 publications

Suppressive Effect of Kampo Formula “Juzen-taiho-to” on Carbon Tetrachloride-Induced Hepatotoxicity in Mice

Suppressive Effect of Kampo Formula “Juzen-taiho-to” on Carbon Tetrachloride-Induced Hepatotoxicity in Mice

In vivo antioxidant activity of phenolic compounds: Facts and gaps

Kampo formula “Hochu-ekki-to” suppressed carbon tetrachloride-induced hepatotoxicity in mice

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