Characterization of chemical compositions by a GC–MS/MS approach and evaluation of antioxidant activities of essential oils from Cinnamomum reticulatum Hay, Leptospermum petersonii Bailey, and Juniperus formosana Hayata

Li, Yuanhang; Cao, Xinxin; Sun, Jing; Zhang, Wanqi; Zhang, Jin; You-fang, Ding

doi:10.1016/j.arabjc.2021.103609

Cited by 4 publications

(1 citation statement)

References 35 publications

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“…The essential oils from other plants from the Myrtaceae family also present anti-inflammatory responses, and most of their mechanisms create responses of antioxidant activity, reduction in cell migration, and inhibition of cytokines, nitric oxide, and other inflammatory mediators [ 94 , 95 , 96 ]. In addition, a study with extracts of Plinia cauliflora leaves and branches also showed reduced croton oil-induced ear edema [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

Potential Effects of Essential Oil from Plinia cauliflora (Mart.) Kausel on Leishmania: In Vivo, In Vitro, and In Silico Approaches

Holanda,

Brito,

Oliveira

et al. 2024

Microorganisms

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In the search for new chemotherapeutic alternatives for cutaneous leishmaniasis (CL), essential oils are promising due to their diverse biological potential. In this study, we aimed to investigate the chemical composition and leishmanicidal and anti-inflammatory potential of the essential oil isolated from the leaves of Plinia cauliflora (PCEO). The chemical composition of PCEO showed β-cis-Caryophyllene (24.4%), epi-γ-Eudesmol (8%), 2-Naphthalenemethanol[decahydro-alpha] (8%), and trans-Calamenene (6.6%) as its major constituents. Our results showed that the PCEO has moderate cytotoxicity (CC50) of 137.4 and 143.7 μg/mL on mice peritoneal exudate cells (mPEC) and Vero cells, respectively. The PCEO was able to significantly decrease mPEC infection by Leishmania amazonensis and Leishmania braziliensis. The value of the inhibitory concentration (IC50) on amastigote forms was about 7.3 µg/mL (L. amazonensis) and 7.2 µg/mL (L. braziliensis). We showed that PCEO induced drastic ultrastructural changes in both species of Leishmania and had a high selectivity index (SI) > 18. The in silico ADMET analysis pointed out that PCEO can be used for the development of oral and/or topical formulation in the treatment of CL. In addition, we also demonstrated the in vivo anti-inflammatory effect, with a 95% reduction in paw edema and a decrease by at least 21.4% in migration immune cells in animals treated with 50 mg/kg of PCEO. Taken together, our results demonstrate that PCEO is a promising topical therapeutic agent against CL.

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Section: Resultsmentioning

confidence: 99%

Potential Effects of Essential Oil from Plinia cauliflora (Mart.) Kausel on Leishmania: In Vivo, In Vitro, and In Silico Approaches

Holanda,

Brito,

Oliveira

et al. 2024

Microorganisms

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Chemometrics of the composition and antioxidant capacity of essential oils obtained from six Cupressaceae taxa

Xie,

Liu

2024

Sci Rep

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Essential oils (EOs) are complex and susceptible to environmental conditions, they have a wide range of biological activities and are often used to differentiate between similar species. In this study, gas chromatography-mass spectrometry (GC–MS) coupled with chemometric analysis was applied to systematically analyse and evaluate EOs constituents and antioxidant activity of six Chinese Cupressaceae taxa ( Platycladus orientalis Franco, P . orientalis Franco ‘Sieboldii’, P . orientalis Franco ‘Aurea’, Juniperus chinensis Roxb., J . chinensis Roxb. ‘Kaizuca’, and J . sabina L.) under identical conditions. The antioxidant activity of the EOs was evaluated using 2,2 -diphenyl-1-picrylhydrazyl (DPPH), 2,2’-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), and ferric reducing power (FRAP), and the total phenolic content (TPC) of the EOs was determined by Folin–Ciocalteau reagent. In total, seventy individual constituents were identified with the main components being α-pinene, sabinene, d -limonene, bornyl acetate, δ-3-carene and β-myrcene. Principal component analysis (PCA) and hierarchal cluster analysis (HCA) successfully discriminated the six taxa into three chemotypes and the unique chemotype revealed that J . chinensis ‘Kaizuca’ may be a species rather than a cultivar of J . chinensis . The results of OPLS-DA analysis showed that the three compounds screened, namely, α-pinene, sabinene, and δ-3-carene, can completely distinguish Platycladus spp. from Juniperus spp. The DPPH assay results ranged from 576.14 ( J. chinensis ‘Kaizuca’) to 1146.12 ( J. sabina ) μmol eq Trolox/mL EO, while the ABTS values ranged from 1579.62 ( P . orientalis ‘Aurea’) to 5071.82 ( J. sabina ) μmol eq Trolox/mL. In the FRAP assay, the values ranged from 1086.50 ( J. chinensis ‘Kaizuca’) to 1191.18 ( J. sabina ) μmol eq Trolox/ml and the TPC of the EOs studied ranged from 15.17 ( J. chinensis ‘Kaizuca’) to 39.37 ( J. sabina ) mg GAE/mL EO. The results consistently showed that J . sabina possessed the strongest antioxidant activity and can be preferentially used as a rich source of potentially natural antioxidants.

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Bio-Inspired Synthesis of Gold Nanoparticles Using Leaf Extract of Jamun and Research on Its Biomedical Potential

Das,

Shin,

Lim

et al. 2024

IJN

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Background Bio-based synthesis of metallic nanoparticles has garnered much attention in recent times owing to their non-toxic, environmentally friendly, and cost-effective nature. Methods In this study, gold nanoparticles (S4-GoNPs) were synthesized by a simple and environmentally friendly technique using an aqueous extract of jamun leaves (JLE) as an effective capping, stabilizer, and reducing agent. JLE was screened for the presence of phytochemicals followed by synthesis, characterization, and evaluation of their antibacterial, antidiabetic, antioxidant, and photocatalytic degradation potentials using standard established procedures. Results The phytochemical profile of JLE was found to be rich in flavonoids, tannins, terpenoid phenols, anthraquinones, and cardiac glycosides. Its GC-MS analysis revealed the presence of compounds majorly of them as the (1R)-2,6,6-Trimethylbicyclo[3.1.1]hept-2-ene (5.141%), 2(10)-pinene (4.119%), α-cyclopene (5.274%) α,α-muurolene (7.525%), naphthalene, 1,2,3,4,4a,5,6,8a-octahydro-7-methyl-4-methylene-1-(1-methylethyl)-(1.alpha.,4a.beta.,8a.alpha) (8.470%), delta-cadinene (23.246), α-guajene (3.451%), and gamma-muurolene (4.379%). The visual morphology and UV–Vis spectral surface plasmon resonance at 538 nm confirmed the successful synthesis of S4-GoNPs. The average particle size was determined as 120.5 nm with Pdi = 0.152, and −27.6 mV zeta potential. Using the Scherrer equation, the average crystallite size was calculated as 35.69 nm. S4-GoNPs displayed significant antidiabetic properties, with 40.67% of α-amylase and 91.33% of α-glucosidase inhibition activity. It also exhibited promising antioxidant potential in terms of the DPPH (91.56%) ABTS (76.59%) scavenging. It displayed 31.04% tyrosinase inhibition at 0.1 mg/mL. Moreover, it also demonstrated encouraging antibacterial effects with zones of inhibition ranging from 11.02 – 14.12 mm as compared to 10.55–16.24 mm by the reference streptomycin (at 0.01 mg/disc). In addition, S4-GoNPs also showed potential for the photocatalytic degradation of the industrial dye, methylene blue. Conclusion In conclusion, these results suggest the promising applicability of green-synthesized S4-GoNPs in various sectors, including the biomedical, cosmetic, food, and environmental waste management industries.

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Characterization of chemical compositions by a GC–MS/MS approach and evaluation of antioxidant activities of essential oils from Cinnamomum reticulatum Hay, Leptospermum petersonii Bailey, and Juniperus formosana Hayata

Cited by 4 publications

References 35 publications

Potential Effects of Essential Oil from Plinia cauliflora (Mart.) Kausel on Leishmania: In Vivo, In Vitro, and In Silico Approaches

Potential Effects of Essential Oil from Plinia cauliflora (Mart.) Kausel on Leishmania: In Vivo, In Vitro, and In Silico Approaches

Chemometrics of the composition and antioxidant capacity of essential oils obtained from six Cupressaceae taxa

Bio-Inspired Synthesis of Gold Nanoparticles Using Leaf Extract of Jamun and Research on Its Biomedical Potential

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