Characterization of chlorhexidine-releasing, fast-setting, brushite bone cements

Young, Alison; Ng, Poon Yun J.; Gbureck, Uwe; Nazhat, Showan N.; Barralet, Jake E.; Hofmann, Michael

doi:10.1016/j.actbio.2007.12.009

Cited by 53 publications

(57 citation statements)

References 30 publications

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“…Additional advantages are provided if the material is injectable, biodegradable, sets at ambient temperature, has both near neutral pHs and a large surface area [36,37]. These properties make self-setting calcium orthophosphate formulations to be very attractive candidates as drug carriers for therapeutic peptides [537], antibiotics [538][539][540][541][542][543][544][545][546][547], anticancer drugs [578], anti-inflammatory drugs [549,550], cytokines [551], hormones [552] and bone morphogenetic proteins [432,[553][554][555][556][557]. For example, a "growth factor cement" has been reported [558].…”

Section: Drug Delivery Applicationsmentioning

confidence: 99%

“…After setting, the drugs are slowly released through the cement pores [210,[543][544][545][546]562,563]. For example, a group of investigators added flomoxef sodium to a cement formulation and found that the release of antibiotic could be easily controlled in vivo by adjusting the content of sodium alginate in the formula [210].…”

Section: Drug Delivery Applicationsmentioning

confidence: 99%

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Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are a bioactive and biodegradable grafting material in the form of a powder and a liquid. Both phases after mixing form a viscous paste that after being implanted sets and hardens within the body as either a non-stoichiometric calcium deficient hydroxyapatite (CDHA) or brushite, sometimes blended with un-reacted particles and other phases. As both CDHA and brushite are remarkably biocompartible and bioresorbable (therefore, in vivo they can be replaced with a newly forming bone), self-setting calcium orthophosphate cements represent a good correction technique of non-weight-bearing bone fractures or defects and appear to be very promising materials for bone grafting applications. Besides, these cements possess an excellent osteoconductivity, molding capabilities, and easy manipulation. Nearly perfect adaptation to the tissue surfaces in bone defects and a gradual bioresorption followed by new bone formation are additional distinctive advantages of calcium orthophosphate cements. Besides, reinforced formulations are available; those are described as calcium orthophosphate concretes. Furthermore, formulations with high viscosity, such as pastes and putties are also known. The discovery of self-setting formulations has opened up a new era in the medical application of calcium orthophosphates; several commercial compositions have already been introduced as a result. Many more formulations are in experimental stages. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent biomaterials suitable for both dental and bone grafting applications, has been provided.

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Section: Drug Delivery Applicationsmentioning

confidence: 99%

Section: Drug Delivery Applicationsmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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“…The drug release from CPCs has commonly been monitored using pre-set specimens, which were allowed to set for different periods, varying from 10-20 min [8], overnight [9], or 24 h [10][11][12][13][14][15][16][17] up to 7 days [10]. Moreover, in several studies [18][19][20][21][22] the conditions used were not indicated.…”

Section: Introductionmentioning

confidence: 99%

Changes in the drug release pattern of fresh and set simvastatin-loaded brushite cement

Mestres

Kugiejko

Pastorino

et al. 2016

Materials Science and Engineering: C

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Calcium phosphate cements are synthetic bone graft substitutes able to set at physiological conditions. They can be applied by minimally invasive surgery and can also be used as drug delivery systems.Consequently, the drug release pattern from the cement paste (fresh cement) is of high clinical interest.However, previous studies have commonly evaluated the drug release using pre-set cements only.Therefore, the aim of this work was to determine if the time elapsed from cement preparation until immersion in the solution (3 min for fresh cements, and 1 h and 15 h for pre-set cements) had an influence on its physical properties, and correlating these to the drug release profile. Simvastatin was selected as a model drug, while brushite cement was used as drug carrier. This study quantified how the setting of a material reduces the accessibility of the release media to the material, thus preventing drug release. A shift in the drug release pattern was observed, from a burst-release for fresh cements to a sustained release for pre-set cements.

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“…Additional advantages are provided if the biomaterial is injectable, biodegradable, sets at ambient temperature, has both near neutral pHs and a large surface area [52,53]. These properties make self-setting calcium orthophosphate formulations to be very attractive candidates as drug carriers for therapeutic peptides [617], antibiotics [26,[618][619][620][621][622][623][624][625][626][627][628][629], anticancer [630][631][632][633][634] and anti-inflammatory agents [635,636], cytokines [637], hormones [638], bone morphogenetic proteins [488,[639][640][641][642][643] and other biologically active compounds [644][645][646][647][648][649][650][651]. For example, a -growth factor cement‖ has been reported [652].…”

Section: Drug Deliverymentioning

confidence: 99%

“…According to a topical review on the subject [219], there are 3 options of drug existence inside the matrix: (a) dissolved in the remaining liquid phase within the existing pores among the newly formed inorganic crystals; (b) adsorbed or chemically bound on the surface of the crystals; or (c) in a solid form inside pores ( Figure 15). Studies on drug release are the second most important topic on drugs incorporation into the self-setting formulations [238,[623][624][625][626]656,657]. This process is regulated by the microstructure of the set formulations (i.e., their porosity), as well as by presence or absence of additives able to influence the movement of drug molecules within the solid matrix.…”

Section: Drug Deliverymentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations

Dorozhkin¹

2012

Calcium Orthophosphates

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Abstract:In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are bioactive and biodegradable grafting bioceramics in the form of a powder and a liquid. After mixing, both phases form pastes, which set and harden forming either a non-stoichiometric calcium deficient hydroxyapatite or brushite. Since both of them are remarkably biocompartible, bioresorbable and osteoconductive, self-setting calcium orthophosphate formulations appear to be promising bioceramics for bone grafting. Furthermore, such formulations possess excellent molding capabilities, easy manipulation and nearly perfect adaptation to the complex shapes of bone defects, followed by gradual bioresorption and new bone formation. In addition, reinforced formulations have been introduced, which might be described as calcium orthophosphate concretes. The discovery of self-setting properties opened up a new era in the medical application of calcium orthophosphates and many commercial trademarks have been introduced as a result. Currently such formulations are widely used as synthetic bone grafts, with several advantages, such as pourability and injectability. Moreover, their low-temperature setting reactions and intrinsic porosity allow loading by drugs, biomolecules and even cells for tissue engineering purposes. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent bioceramics suitable for both dental and bone grafting applications, has been provided.

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Characterization of chlorhexidine-releasing, fast-setting, brushite bone cements

Cited by 53 publications

References 30 publications

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Changes in the drug release pattern of fresh and set simvastatin-loaded brushite cement

Self-Setting Calcium Orthophosphate Formulations

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