Characterization of crab EcR and RXR homologs and expression during limb regeneration and oocyte maturation

Durica, David S.; Wu, Xiaohui; Anilkumar, Gopinathan; Hopkins, Penny M.; Chung, Arthur C.K.

doi:10.1016/s0303-7207(01)00740-7

Cited by 96 publications

(67 citation statements)

References 100 publications

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“…EcR belongs to a nuclear receptor family (receptors acting as transcription factors), and it has a typical gene composition of five domains from which DNA-binding domain (DBD) and ligand-binding domain (LBD) are phylogenetically conserved. Analyses of these two domains in Uca pugilator (Durica et al 2002) and Gecarcinus lateralis Freminville, 1835 (Kim et al 2005a) revealed high similarity to EcR from insects. Recent studies with U. pugilator also suggested temporal-and organ/tissue-specific distribution of several EcR isoforms (Durica et al 2002).…”

Section: Role Of Classical Endocrine Glands In Reproductionmentioning

confidence: 99%

“…Analyses of these two domains in Uca pugilator (Durica et al 2002) and Gecarcinus lateralis Freminville, 1835 (Kim et al 2005a) revealed high similarity to EcR from insects. Recent studies with U. pugilator also suggested temporal-and organ/tissue-specific distribution of several EcR isoforms (Durica et al 2002). It may be deduced that various EcRs control specific responses in different organs and determine thus tissue sensitivity to ecdysteroids (Kim et al 2005a;Zou 2005).…”

Section: Role Of Classical Endocrine Glands In Reproductionmentioning

confidence: 99%

“…In the nucleus of responsive crustacean cells, activated EcR hybridizes with another important nuclear receptor, retinoid X receptor (RXR) (Durica et al 2002). RXR derived from fiddler crab U. pugilator (UpRXR) also exists in various isoforms (differing in splicing hinge regions), and it has been shown that only RXR isoform with a specific hinge region in LBD domain (UpRXR+33) may hybridize with EcR, bind to ecdysteroid hormone responsive elements on DNA and modulate expression of target genes (Durica et al 2002).…”

Section: Role Of Classical Endocrine Glands In Reproductionmentioning

confidence: 99%

“…RXR derived from fiddler crab U. pugilator (UpRXR) also exists in various isoforms (differing in splicing hinge regions), and it has been shown that only RXR isoform with a specific hinge region in LBD domain (UpRXR+33) may hybridize with EcR, bind to ecdysteroid hormone responsive elements on DNA and modulate expression of target genes (Durica et al 2002). It is also known that the DBD domain of crustacean RXR is closely related to insect ultraspiracle (USP) receptor, while LBD of RXR shares greater similarity to vertebrate RXRs rather than to USP (Wu et al 2004).…”

Section: Role Of Classical Endocrine Glands In Reproductionmentioning

confidence: 99%

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Endocrine regulation of the reproduction in crustaceans: Identification of potential targets for toxicants and environmental contaminants

et al. 2008

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Progress in ecotoxicological research documents that crustaceans are highly vulnerable to diverse chemicals and toxicants in the environment. In particular, pollutants affecting endocrine homeostasis in crustaceans (i.e., endocrine disruptors) are intensively studied, and serious reproductive disorders have been documented. In this review, current knowledge about the endocrine regulation of the crustacean reproduction is put together with the published ecotoxicological data with an attempt to summarize the potential of xenobiotics to affect crustacean reproduction. Following gaps and trends were identified: (1) Studies are required in the field of neurohormone (serotonin and dopamine) regulation of the reproduction and possible modulations by environmental toxicants such as antidepressant drugs. (2) Molting-related parameters (regulated by ecdysteroid hormones) are closely coordinated with the development and reproduction cycles in crustaceans (cross-links with methyl farnesoate signalling), and their susceptibility to toxicants should be studied. (3) Other biochemical targets for xenobiotics were recently discovered in crustaceans and these should be explored by further ecotoxicological studies (e.g., new information about ecdysteroid receptor molecular biology). (4) Some sex steroid hormones known from vertebrates (testosterone, progesterone) have been reported in crustaceans but knowledge about their targets (crustacean steroid receptors) and signalling is still limited. (5) Determination of the sex in developing juveniles (affecting the sex ratio in population) is a sensitive parameter to various xenobiotics (including endocrine disruptors) but its modulation by general environmental stress and non-specific toxicity should be further studied.

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Section: Role Of Classical Endocrine Glands In Reproductionmentioning

confidence: 99%

Section: Role Of Classical Endocrine Glands In Reproductionmentioning

confidence: 99%

Section: Role Of Classical Endocrine Glands In Reproductionmentioning

confidence: 99%

Section: Role Of Classical Endocrine Glands In Reproductionmentioning

confidence: 99%

See 2 more Smart Citations

Endocrine regulation of the reproduction in crustaceans: Identification of potential targets for toxicants and environmental contaminants

et al. 2008

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“…This dose was selected based on the results of experiment 1 (see below). Hemolymph was withdrawn from injected crabs at different time points (30,60,120, and 360 min) and used for glucose quantification as described in experiment 1.…”

Section: Experimental Designmentioning

confidence: 99%

13-Cis-Retinoic Acid-Induced Hyperglycemia in the Fresh Water Edible Crab, Oziothelphusa Senex Senex is mediated by Triggering Release of Hyperglycemic Hormone from Eyestalks

P¹,

Srilatha²

2015

J Aquac Res Development

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Regeneration in Crustaceans and Insects

Khan

Schuster

Smith-Bolton

2016

Encyclopedia of Life Sciences

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Many animal species have the capability to regenerate lost body parts. How regeneration takes place and why animals have varying potentials for regeneration remain active questions for biologists. The field of regenerative biology has witnessed unprecedented advances in the last several years owing to the availability of molecular and genomics tools and the establishment of many animal models. Regeneration research in arthropods has a long history, with extensive insights achieved from using model organisms from the taxa Crustacea and Insecta. Studies in animals ranging from fiddler crabs to crickets have revealed much about the different stages of regeneration, such as wound healing, blastema formation, growth, proliferation and patterning, as well as how hormonal control and systemic signalling impact regenerative capacity. The molecular and genetic insights achieved from studying these simpler model organisms have the potential to impact the field of regenerative biology by identifying conserved mechanisms of regeneration. Key Concepts Regeneration studies use the fiddler crab, crayfish, sand hopper, red flour beetle, fruit fly, cockroach, cricket and silverfish. For amputated limbs, wounds heal by a combination of rapid closure of the wound with a scab or autotomy membrane, and migration of cells into the wound. Imaginal disc wound closure involves cytoskeletal‐driven cell shape changes and zippering together of the epithelium, without cell migration. A regeneration blastema, or zone of proliferating cells, forms after both external limb amputation and imaginal disc damage. Growth of the blastema requires similar signals in multiple model organisms, including growth factor signalling in response to FGFs and EGFR activity, Wg/WNT signalling and Hippo signalling. Many developmental patterning genes are also required for patterning during regeneration. However, knockdown of these patterning genes revealed additional roles in regeneration beyond those observed during normal development. Some plasticity in cell fate enables replacement of lost cell types. Signals at the wound can alter pattern and cell fate, generating ectopic eye spots in butterflies and requiring the activity of a protective factor that stabilises cell fate gene expression during regeneration in fruit flies. Hormonal signalling, which controls moulting and metamorphosis, limits regenerative capacity. In some model organisms, tissue damage can influence hormone production and the timing of moults and metamorphosis.

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Characterization of crab EcR and RXR homologs and expression during limb regeneration and oocyte maturation

Cited by 96 publications

References 100 publications

Endocrine regulation of the reproduction in crustaceans: Identification of potential targets for toxicants and environmental contaminants

Endocrine regulation of the reproduction in crustaceans: Identification of potential targets for toxicants and environmental contaminants

13-Cis-Retinoic Acid-Induced Hyperglycemia in the Fresh Water Edible Crab, Oziothelphusa Senex Senex is mediated by Triggering Release of Hyperglycemic Hormone from Eyestalks

Regeneration in Crustaceans and Insects

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