Characterization of environmental nanoparticles

Fukuhara, Nobuhiko; Suzuki, Ken‐ichiro; Takeda, Ken; Nihei, Yoshimasa

doi:10.1016/j.apsusc.2008.05.013

Cited by 21 publications

(15 citation statements)

References 7 publications

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“…This SIMS analysis of layer formation was particularly effective when combined with zeta‐potential measurements. Furthermore, SIMS analysis was used to characterize environmental NPs from the atmosphere with two distinct size distributions (20 and 100 nm) (Fukuhara et al, ). Interestingly, size‐dependent characteristic peaks were observed: C + , O + , Si + , and SiH 3 peaks from 20 nm, presumably from fuels and engine oils, and NH 4 + , Na + , K + , and Ca + from 100 nm, presumably from diesel exhaust particles.…”

Section: Probing Nanoparticles By Tof‐simsmentioning

confidence: 99%

Probing nanoparticles and nanoparticle‐conjugated biomolecules using time‐of‐flight secondary ion mass spectrometry

Kim

Shon

Shin

et al. 2014

Mass Spectrometry Reviews

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Bio-conjugated nanoparticles have emerged as novel molecular probes in nano-biotechnology and nanomedicine and chemical analyses of their surfaces have become challenges. The time-offlight (TOF) secondary ion mass spectrometry (SIMS) has been one of the most powerful surface characterization techniques for both nanoparticles and biomolecules. When combined with various nanoparticle-based signal enhancing strategies, TOF-SIMS can probe the functionalization of nanoparticles as well as their locations and interactions in biological systems. Especially, nanoparticle-based SIMS is an attractive approach for labelfree drug screening because signal-enhancing nanoparticles can be designed to directly measure the enzyme activity. The chemical-specific imaging analysis using SIMS is also well suited to screen nanoparticles and nanoparticle-biomolecule conjugates in complex environments. This review presents some recent applications of nanoparticle-based TOF-SIMS to the chemical analysis of complex biological systems.

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Section: Probing Nanoparticles By Tof‐simsmentioning

confidence: 99%

Probing nanoparticles and nanoparticle‐conjugated biomolecules using time‐of‐flight secondary ion mass spectrometry

Kim

Shon

Shin

et al. 2014

Mass Spectrometry Reviews

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“…For example, maternal exposure to dioxin induced atrophy of thymus and decrease of thymocytes in the offspring (Camacho et al, 2004;Mustafa et al, 2009). Recently, maternal exposure to nanoparticles (defined as substances measuring 1-100 nm in at least one dimension) in nanotechnology (Kessler, 2011) or to those suspended in the air (Fukuhara, et al, 2008), has become a major focus in research on environmental effects on human health.…”

Section: Introductionmentioning

confidence: 99%

Effect of maternal exposure to carbon black nanoparticle during early gestation on the splenic phenotype of neonatal mouse

et al. 2014

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Maternal exposure to environmental factors is implicated as a major factor in the development of the immune system in newborns. Newborns are more susceptible to microbial infection because their immune system is immature. Development of lymphocytes reflects an innate program of lymphocyte proliferation. The aim of this study was to investigate the effects of maternal exposure to carbon black nanoparticle (CB-NP) during early gestation on the development of lymphoid tissues in infantile mice. Pregnant ICR mice were treated with a suspension of CB-NP (95 μg kg(-1) time(-1)) by intranasal instillation on gestational day 5 and 9. Spleen tissues were collected from offspring mice at 1, 3, 5, and 14 days postpartum. Splenocyte phenotypes were examined by investigating the pattern of surface molecules using flow cytometry. Gene expression in the spleen was examined by quantitative RT-PCR. CD3(+) (T), CD4(+) and CD8(+) cells were decreased in the spleen of 1-5-day-old offspring in the treated group. Expression level of Il15 was significantly increased in the spleen of newborn male offspring, and Ccr7 and Ccl19 were increased in the spleen of female offspring in the CB-NP group. Splenic mRNA change profiles by CBNP were similar between male and female offspring. This article concluded that exposure of pregnant mothers to CB-NP partially suppressed the development of the immune system of offspring mice. The decrease in splenic T cells in the treated group recovered at 14 days after birth. This is the first report of developmental effect of nanoparticle on the lymphatic phenotype.

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“…Rapid non-microscopic approaches to the identification of particle composition are desired to confirm that the sized materials are composed of the material in question. Hyphenated methods such as ES-DMA–inductively coupled plasma mass spectroscopy (ICP-MS) ( Carazzone et al 2008 ), ES-DMA–time of flight secondary ion mass spectroscopy (TOF-SIMS) ( Fukuhara et al 2008 ), and FFF–ICP-MS ( Stolpe et al 2005 ) have recently been applied; however, additional work is warranted.…”

Section: Research Needs In Nano-object Count Metrologymentioning

confidence: 99%

Toward Advancing Nano-Object Count Metrology: A Best Practice Framework

Brown

Boyko

Meyers

et al. 2013

Environ Health Perspect

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Background: A movement among international agencies and policy makers to classify industrial materials by their number content of sub–100-nm particles could have broad implications for the development of sustainable nanotechnologies.Objectives: Here we highlight current particle size metrology challenges faced by the chemical industry due to these emerging number percent content thresholds, provide a suggested best-practice framework for nano-object identification, and identify research needs as a path forward.Discussion: Harmonized methods for identifying nanomaterials by size and count for many real-world samples do not currently exist. Although particle size remains the sole discriminating factor for classifying a material as “nano,” inconsistencies in size metrology will continue to confound policy and decision making. Moreover, there are concerns that the casting of a wide net with still-unproven metrology methods may stifle the development and judicious implementation of sustainable nanotechnologies. Based on the current state of the art, we propose a tiered approach for evaluating materials. To enable future risk-based refinements of these emerging definitions, we recommend that this framework also be considered in environmental and human health research involving the implications of nanomaterials.Conclusion: Substantial scientific scrutiny is needed in the area of nanomaterial metrology to establish best practices and to develop suitable methods before implementing definitions based solely on number percent nano-object content for regulatory purposes. Strong cooperation between industry, academia, and research institutions will be required to fully develop and implement detailed frameworks for nanomaterial identification with respect to emerging count-based metrics.Citation: Brown SC, Boyko V, Meyers G, Voetz M, Wohlleben W. 2013. Toward advancing nano-object count metrology: a best practice framework. Environ Health Perspect 121:1282–1291; http://dx.doi.org/10.1289/ehp.1306957

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Characterization of environmental nanoparticles

Cited by 21 publications

References 7 publications

Probing nanoparticles and nanoparticle‐conjugated biomolecules using time‐of‐flight secondary ion mass spectrometry

Probing nanoparticles and nanoparticle‐conjugated biomolecules using time‐of‐flight secondary ion mass spectrometry

Effect of maternal exposure to carbon black nanoparticle during early gestation on the splenic phenotype of neonatal mouse

Toward Advancing Nano-Object Count Metrology: A Best Practice Framework

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