Characterization of GECPAR, a noncoding RNA that regulates the transcriptional program of diffuse large B-cell lymphoma

Napoli, Sara; Cascione, Luciano; Rinaldi, Andrea; Spriano, Filippo; Guidetti, Francesca; Zhang, Fangwen; Cacciapuoti, Maria Teresa; Mensah, Afua Adjeiwaa; Sartori, Giulio; Munz, Nicolas; Forcato, Mattia; Bicciato, Silvio; Chiappella, Annalisa; Ghione, Paola; Elemento, Olivier; Cerchietti, Leandro; Inghirami, Giorgio; Bertoni, Francesco

doi:10.3324/haematol.2020.267096

Cited by 3 publications

(2 citation statements)

References 62 publications

(35 reference statements)

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“…This gene was previously thought to be speci cally expressed in lymphocytes. POU2AF1 encodes OCA-B protein(coactivator of OCT2, as a B cell speci c TF), plays a pivotal role in the regulation of normal and neoplastic germinal center B cells 31 . Thus, we think that POU2AF1 might be therapeutic targets for COVID-19-related airway diseases.…”

Section: Discussionmentioning

confidence: 99%

The underlying molecular mechanisms and biomarkers between periodontitis and COVID- 19

Qin

et al. 2023

Preprint

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Objective Emerging evidence shows the clinical consequences of patient with COVID-19 and periodontitis are not promising, and periodontitis is a risk factor. Periodontitis and COVID-19 probably have a relationship. Hence, this study aimed to identify the common molecular mechanism that may help to devise potential therapeutic strategies in the future. Material and methods We analyzed two RNA-seq datasets for differential expressed genes, enrichment of biological processes, transcription factors (TFs) and deconvolution-based immune cell types in periodontitis, COVID-19 and healthy controls. Relationships between TFs and mRNA were established by Pearson correlation analysis, and the common TFs-mRNA regulatory network and nine co-upregulated TFs of the two diseases was obtained. The RT-PCR detected the TFs. Results A total of 1616 and 10201 DEGs from periodontitis and COVID-19 are found. Moreover, nine shared TFs and common biological processes associated with lymphocyte activation involved in immune response were identified across periodontitis and COVID-19. The cell type enrichment revealed elevated plasma cells among two diseases. The RT-PCR further confirmed the nine TFs up-regulation in periodontitis. Conclusion The pathogenesis of periodontitis and COVID-19 is closely related to the expression of TFs and lymphocyte activation, which can provide potential targets for treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

The underlying molecular mechanisms and biomarkers between periodontitis and COVID- 19

Qin

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…This gene was previously thought to be specifically expressed in lymphocytes. POU2AF1 encodes OCA-B protein(coactivator of OCT2, as a B cell specific TF), plays a pivotal role in the regulation of normal and neoplastic germinal center B cells [ 38 ]. Thus, we think that POU2AF1 might be therapeutic targets for COVID-19-related airway diseases.…”

Section: Discussionmentioning

confidence: 99%

The underlying molecular mechanisms and biomarkers between periodontitis and COVID-19

Qin¹,

Yu²,

Wu³

et al. 2023

BMC Oral Health

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Objective Emerging evidence shows the clinical consequences of patient with COVID-19 and periodontitis are not promising, and periodontitis is a risk factor. Periodontitis and COVID-19 probably have a relationship. Hence, this study aimed to identify the common molecular mechanism that may help to devise potential therapeutic strategies in the future. Material and methods We analyzed two RNA-seq datasets for differential expressed genes, enrichment of biological processes, transcription factors (TFs) and deconvolution-based immune cell types in periodontitis, COVID-19 and healthy controls. Relationships between TFs and mRNA were established by Pearson correlation analysis, and the common TFs-mRNA regulatory network and nine co-upregulated TFs of the two diseases was obtained. The RT-PCR detected the TFs. Results A total of 1616 and 10201 differentially expressed gene (DEGs) from periodontitis and COVID-19 are found. Moreover, nine shared TFs and common biological processes associated with lymphocyte activation involved in immune response were identified across periodontitis and COVID-19. The cell type enrichment revealed elevated plasma cells among two diseases. The RT-PCR further confirmed the nine TFs up-regulation in periodontitis. Conclusion The pathogenesis of periodontitis and COVID-19 is closely related to the expression of TFs and lymphocyte activation, which can provide potential targets for treatment.

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Enhancer RNAs (eRNAs) in Cancer: The Jacks of All Trades

Napoli

Munz

Guidetti

et al. 2022

Cancers

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Enhancer RNAs (eRNAs) are non-coding RNAs (ncRNAs) transcribed in enhancer regions. They play an important role in transcriptional regulation, mainly during cellular differentiation. eRNAs are tightly tissue- and cell-type specific and are induced by specific stimuli, activating promoters of target genes in turn. eRNAs usually have a very short half-life but in some cases, once activated, they can be stably expressed and acquire additional functions. Due to their critical role, eRNAs are often dysregulated in cancer and growing number of interactions with chromatin modifiers, transcription factors, and splicing machinery have been described. Enhancer activation and eRNA transcription have particular relevance also in inflammatory response, placing the eRNAs at the interplay between cancer and immune cells. Here, we summarize all the possible molecular mechanisms recently reported in association with eRNAs activity.

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Characterization of GECPAR, a noncoding RNA that regulates the transcriptional program of diffuse large B-cell lymphoma

Cited by 3 publications

References 62 publications

The underlying molecular mechanisms and biomarkers between periodontitis and COVID- 19

The underlying molecular mechanisms and biomarkers between periodontitis and COVID- 19

The underlying molecular mechanisms and biomarkers between periodontitis and COVID-19

Enhancer RNAs (eRNAs) in Cancer: The Jacks of All Trades

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