Characterization of group B Streptococcus colonization in full-term and Late-Preterm neonates in Taiwan

Hsu, Jen‐Fu; Chen, Chyi‐Liang; Lee, Cheng-Chung; Lien, Reyin; Chu, Shu Hsun; Fu, Ren-Huei; Chiang, Ming-Chou; Yang, Chih‐Chao; Lai, Ming-Wei; Wu, I-Hsyuan; Yen, Yi‐Hao; Chiu, Cheng-Hsun

doi:10.1016/j.pedneo.2018.07.015

Cited by 17 publications

(13 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, serotype II represented by ST-10 and ST-569, belongs to CC-10 was the most prevalent colonizer of newborns. It is in congruent with that of a study conducted in Taiwan where serotype II was the most colonizer,4/11 (33.3%) [36]. However, it is different from a study conducted before three decades in the same hospital where 60% were type Ib followed by type Ia (16%) [37]; in Poland, serotype III (35%) was the most prevalent types followed by Ia (20%), V (17%), II (15%), Ib (8%) and IV (5%) [38].…”

Section: Discussionsupporting

confidence: 90%

Molecular characterization of Streptococcus agalactiae isolated from pregnant women and newborns at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

et al. 2020

View full text Add to dashboard Cite

Background: Streptococcus agalctiae (Group B Streptococcus, GBS) is a perinatal pathogen and a leading cause of neonatal infections worldwide. Serotype, sequence type, clonality, antibiotic resistance genes and surface protein profiles of GBS are scarce in Ethiopia, a reason that this study was planned to investigate. . Methods: Sixteen colonizing GBS isolates obtained from recto-vaginal swabs of pregnant women and body surfaces of newborns were further analyzed. Minimum inhibitory concentration (MIC) test, and whole genome sequence (WGS) methods were done for antibiotic susceptibility test, and molecular characterization of the isolates. Results: All the GBS isolates analyzed were belonged to four capsular serotypes: II, 11/16(68.8%), V, 3/16(18.8%), Ia and VI each with 1/16(6.3%) and five sequence type (ST-2, ST-10, ST-14, ST-569 and ST-933). Sequence type-10 was the most predominant ST followed by ST-569. The five STs were grouped into the four clonal complexes (CC -1, CC-10, CC-19, and CC-23). Different surface proteins and pili families such as ALP1, ALPHA, ALP23, PI-1 / PI-2A1, PI-1 / PI-2B, and Srr1 were detected from WGS data. All isolates were found to be susceptible to the tested antibiotics except for tetracycline in MIC and WGS test methods used. Tetracycline resistant determinant genes such as TETM and TETL / TETM combination were identified. Conclusion: Further studies on serotype and molecular epidemiology will provide a comprehensive data of the GBS capsular serotype and clones available in Ethiopia.

show abstract

Section: Discussionsupporting

confidence: 90%

Molecular characterization of Streptococcus agalactiae isolated from pregnant women and newborns at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

et al. 2020

View full text Add to dashboard Cite

show abstract

“…3 In Taiwan the prevalence of GBS is 23.7%. 4 Large-scale, multicenter epidemiological studies on maternal GBS colonization in mainland China remain rare. Regional differences in maternal GBS colonization have been noted.…”

Section: Epidemiologymentioning

confidence: 99%

Epidemiology of group B streptococcal infection in pregnant women and diseased infants in mainland China

Huang

Lin

Zhu

et al. 2019

Pediatrics & Neonatology

View full text Add to dashboard Cite

Group B Streptococcus (GBS) is a leading cause of neonatal sepsis and an important cause of maternal disease in many countries; however, no accurate population-based epidemiological data on GBS is yet available in mainland China. In this systematic literature review, we obtained published data regarding the maternal GBS colonization rate, incidence of invasive GBS disease in infants, clinical screening, and the associated GBS typing and clinical outcomes in China. The maternal GBS colonization rate in mainland China ranged from 3.7 to 14.52%, and the incidence of invasive GBS disease in infants was 0.55e1.79 per 1000 live births, with a case fatality risk ranging from 6.45 to 7.1%. Serotype III was the dominant serotype that was observed in GBS isolates. GBS detection and identification has become more commonplace, due to the availability of polymerase chain reaction and DNA microarray technologies. Immunizing pregnant women against GBS is an emerging approach through which newborns are protected from GBS. The available data suggest that five GBS serotypes (Ia, Ib, II, III, and V) account for the majority of the cases of GBS disease in mainland China. Furthermore, conjugate vaccines comprising some or all of these serotypes are of potential value in the prevention of GBS infection.

show abstract

“…There are regional differences of GBS colonization in pregnant women. For example, the reported prevalence of GBS for Africa is 22.4%, Southeast Asia is 11.1% and Taiwan is 23.7% [13][14] . Unfortunately, largescale multicenter epidemiological studies on maternal GBS colonization in mainland China are still rare [15] .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Group B Streptococcus Colonization in Pregnant Women in Jiangsu, East China

Wang

Qiu

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Group B streptococcus (GBS) is the leading cause of early-onset neonatal sepsis. However, GBS was infrequently reported in the developing world in contrast to western countries. This study assessed the prevalence of GBS colonization among pregnant women in Jiangsu, East China and reveled the difference of GBS infection between culture and PCR . Methods: A total of 16,184 pregnant women at 34 to 37 weeks, gestation aged 16–47 years were recruited from Nanjing Kingmed Diagnostics. There were 9022 pregnant women receiving GBS screening by PCR detection only. 7162 pregnant women received GBS screening by bacterial culture and GBS-positive samples were tested for antibiotic resistance. Results: The overall GBS positive rate was 8.7% by PCR and 3.5% by culture. There was no significant age difference of GBS infection, but the 25-29 age group and people aged over 40 years should pay more attention . The 249 GBS-positive samples which detected by culture were all sensitive to penicillin. The prevalence of resistance to erythromycin, clindamycin and levofloxacin was 77.5%, 68.3% and 52.2%, respectively. Conclusions: This study revealed the data on the prevalence of GBS colonization in pregnant women in Jiangsu, East China. And it compared the difference of GBS infection between culture and PCR. PCR was expectd to become a quick method in pregnancy women conventional detection of GBS infection.

show abstract

Characterization of group B Streptococcus colonization in full-term and Late-Preterm neonates in Taiwan

Abstract: GBS was carried in 2.2% (11/500) healthy newborns and persisted for 6 months in 3 neonates. This study makes clearer our understanding of GBS colonization, serotype distribution, and genotype distribution in healthy neonates.

Cited by 17 publications

References 35 publications

Molecular characterization of Streptococcus agalactiae isolated from pregnant women and newborns at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

Molecular characterization of Streptococcus agalactiae isolated from pregnant women and newborns at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

Epidemiology of group B streptococcal infection in pregnant women and diseased infants in mainland China

Prevalence of Group B Streptococcus Colonization in Pregnant Women in Jiangsu, East China

Contact Info

Product

Resources

About