Characterization of human aortic collagen's elasticity by nuclear magnetic resonance

Vinée, P; Meurer, B.; Constantinesco, A.; Kohlberger, Bernd; Hauenstein, Karlheinz; Laubenberger, Jörg; Petkov, Simeon

doi:10.1016/0730-725x(93)90072-l

Cited by 1 publication

(1 citation statement)

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“…The mobility and rigidity of the collagen molecules under progressive strain have also been investigated by solid-state proton NMR in mammalian arterial wall after the selective removal of elastin. This approach indicated that a reduction in mobility of the chains accounts for the slope of the stress-strain curve of the bulk material at high strain (Vinee et al 1993), as would be expected in an elastomer. These ndings suggested a model for the elasticity of collagen closely similar to that proposed by Misof et al (1997) (see above).…”

Section: (B) Liquid Crystalline Assemblymentioning

confidence: 85%

Biological liquid crystal elastomers

Knight

Vollrath

2002

Phil. Trans. R. Soc. Lond. B

102

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Liquid crystal elastomers (LCEs) have recently been described as a new class of matter. Here we review the evidence for the novel conclusion that the fibrillar collagens and the dragline silks of orb web spiders belong to this remarkable class of materials. Unlike conventional rubbers, LCEs are ordered, rather than disordered, at rest. The identification of these biopolymers as LCEs may have a predictive value. It may explain how collagens and spider dragline silks are assembled. It may provide a detailed explanation for their mechanical properties, accounting for the variation between different members of the collagen family and between the draglines in different spider species. It may provide a basis for the design of biomimetic collagen and dragline silk analogues by genetic engineering, peptide- or classical polymer synthesis. Biological LCEs may exhibit a range of exotic properties already identified in other members of this remarkable class of materials. In this paper, the possibility that other transversely banded fibrillar proteins are also LCEs is discussed.

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Section: (B) Liquid Crystalline Assemblymentioning

confidence: 85%