Characterization of Mouse Sialyltransferase Genes: Their Evolution and Diversity

Takashima, Shou

doi:10.1271/bbb.80025

Cited by 110 publications

(101 citation statements)

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“…43 Ganglioside GD1a is synthesized from GM1a by a 2,3 sialyltransferase (ST3Gal) I and/or II. 45 RT-PCR analysis showed that the expression of ST3Gal I was much higher in PC3 cells than in LNCap and PNT2 (data not shown). The promoter analysis of STGal I gene revealed that the region from 146 to 304 is involved in the activation of ST3Gal I.…”

Section: Discussionmentioning

confidence: 95%

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Efficient eradication of hormone‐resistant human prostate cancers by inactivated Sendai virus particle

Kawaguchi

Miyamoto

Inoue

et al. 2009

Intl Journal of Cancer

138

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Hormone-refractory prostate cancer is one of the intractable human cancers in the world. Here, we examined the direct tumorkilling activity of inactivated Sendai virus particle [hemagglutinating virus of Japan envelope (HVJ-E)] through induction of Type I interferon (IFN) in the hormone-resistant human prostate cancer cell lines PC3 and DU145. Preferential binding of HVJ-E to PC3 and DU145 over hormone-sensitive prostate cancer cell and normal prostate epithelium was observed, resulting in a number of fused cells. After HVJ-E treatment, a number of IFNrelated genes were up-regulated, resulting in Type I IFN production in PC3 cells. Then, retinoic acid-inducible gene-I (RIG-I) helicase which activates Type I IFN expression after Sendai virus infection was up-regulated in cancer cells after HVJ-E treatment. Produced IFN-a and -b enhanced caspase 8 expression via Janus kinases/Signal Transducers and Activators of Transcription pathway, activated caspase 3 and induced apoptosis in cancer cells. When HVJ-E was directly injected into a mass of PC3 tumor cells in SCID (severe combined immunodeficiency) mice, a marked reduction in the bulk of each tumor mass was observed and 85% of the mice became tumor-free. Although co-injection of an antiasialo GM1 antibody with HVJ-E into each tumor mass slightly attenuated the tumor suppressive activity of HVJ-E, significant suppression of tumor growth was observed even in the presence of anti-asialo GM1 antibody. This suggests that natural killer cell activation made small contribution to tumor regression following HVJ-E treatment in hormone-resistant prostate cancer model in vivo. Thus, HVJ-E effectively targets hormone-resistant prostate cancer by inducing apoptosis in tumor cells, as well as activating anti-tumor immunity. '

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Section: Discussionmentioning

confidence: 95%

“…32 The terminal sialic acid of SPG is transferred by ST3Gal VI. 45 Human ST3Gal VI gene is expressed by alternative promoter utilization and one of the 2 promoters is specifically activated in PC3 cells. 48 The promoter contains putative binding sites for various transcription factors.…”

Section: Discussionmentioning

confidence: 99%

Efficient eradication of hormone‐resistant human prostate cancers by inactivated Sendai virus particle

Kawaguchi

Miyamoto

Inoue

et al. 2009

Intl Journal of Cancer

138

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show abstract

“…GTs are grouped into families of related catalytic or sequence activity in the Carbohydrate Active Enzymes database (CAZy) (Cantarel et al 2009). There are, for example, 20 mammalian sialyltransferases (Takashima 2008). By contrast, Drosophila has a single sialyltransferase (Koles et al 2004), and yeast have none.…”

Section: Golgi Glycosyltransferases General Characteristicsmentioning

confidence: 99%

Golgi Glycosylation

Stanley

2011

Cold Spring Harbor Perspectives in Biology

362

283

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“…To date, 6 members of the ST3Gal family have been identified in mammals. These members can be classified into 2 subfamilies according to amino acid sequence similarities, substrate specificities, and gene structures (6,7,19). The first subfamily consists of 2 members, ST3Gal-I and -II, which preferentially utilize the Galβ1,3GalNAc structure on O-glycans of glycoproteins (core1 O-glycans) and glycolipids as acceptor substrates, respectively (20-22).…”

Section: Functions Of the St3gal Family Membersmentioning

confidence: 99%

“…To date, cDNA cloning of 20 mammalian sialyltransferases has been completed, and their enzymatic properties have been analyzed. These enzymes are grouped into 4 families according to the type of carbohydrate linkage they synthesize (Table): β-galactoside α2,3-sialyltransferases (ST3Gal-I-VI), β-galactoside α2,6-sialyltransferases (ST6Gal-I and -II), N-acetylgalactosamine (GalNAc) α2,6-sialyltransferases (ST6GalNAc-I-VI), and α2,8-sialyltransferases (ST8Sia-I-VI) (4)(5)(6)(7). This review describes the functional diversity of sialyltransferases on the basis of recent studies and discusses the necessity for the expression of as many as 20 different sialyltransferases in mammals.…”

Section: A Introductionmentioning

confidence: 99%