Characterization of Optical and Structure Properties of Polydimethylsiloxanes

Nusa, Hanif Sulistiya; Astuti, Widi; Kartasasmita, Arief; Virgana, Rova; Syakir, Norman; Bahtiar, Ayi; Safriani, Lusi; Risdiana, Risdiana

doi:10.4028/www.scientific.net/msf.827.99

Cited by 15 publications

(21 citation statements)

References 10 publications

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“…Several studies have shown that the low viscosity of PDMS has a higher emulsification tendency than other viscosities. This is influenced by low surface tension and impurities [ 3 ]. Both cause ocular toxicity by spreading to the eye tissue.…”

Section: Discussionmentioning

confidence: 99%

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Physical Characterization and In Vitro Toxicity Test of PDMS Synthesized from Low-Grade D4 Monomer as a Vitreous Substitute in the Human Eyes

Auliya

Setiadji

Fitrilawati

et al. 2022

JFB

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Polydimethylsiloxane (PDMS) is one of the most superior materials and has been used as a substitute for vitreous humor in the human eye. In previous research, we have succeeded in producing PDMS with low and medium viscosity using octamethylcyclotetrasiloxane (D4) monomer with a low grade of 96%. Both have good physical properties and are comparable to commercial product PDMS and PDMS synthesized using D4 monomer with a high grade of 98%. An improvement of the synthesis process is needed to ensure that PDMS synthesized from a low-grade D4 monomer under specific synthesis conditions can repeatedly produce high-quality PDMS. Apart from good physical properties, the PDMS as a substitute for vitreous humor must also be safe and not cause other disturbances to the eyes. Here, we reported the process of synthesizing and characterizing the physical properties of low- and medium-viscosity PDMS using a low-grade D4 monomer. We also reported for the first time the in vitro toxicity test using the Hen’s Egg Test Chorioallantoic Membrane (HET-CAM) test method. We have succeeded in obtaining PDMS with viscosities of 1.15 Pa.s, 1.17 Pa.s, and 1.81 Pa.s. All samples have good physical properties such as refractive index, surface tension, and functional groups that are similar to commercial PDMS. The HET-CAM test results showed that all samples did not show signs of irritation indicating that samples were non-toxic. From the results of this study, it can be concluded that PDMS synthesized from a low-grade D4 monomer under specific synthesis conditions by the ROP method is very safe and has the potential to be developed as a substitute for vitreous humor in human eyes.

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Section: Discussionmentioning

confidence: 99%

“…However, PDMS with low viscosity also has a weakness in the form of a higher possibility of emulsification than PDMS with high viscosity [ 1 ]. Impurities are one of the main reasons for emulsification [ 2 , 3 ]. These impurities are thought to cause ocular toxicity by spreading to the surrounding eye tissue.…”

Section: Introductionmentioning

confidence: 99%

Physical Characterization and In Vitro Toxicity Test of PDMS Synthesized from Low-Grade D4 Monomer as a Vitreous Substitute in the Human Eyes

Auliya

Setiadji

Fitrilawati

et al. 2022

JFB

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“…Previous experiments have been conducted utilizing spectrometers with varying wavelengths and refractive index meters in order to investigate the optical characteristics of SiO in various scenarios, including both used and unused SiO, oils with different viscosities, different durations of intraocular SiO retention, as well as different surgical indications and related procedures. 8,9 Previous research has indicated that eyes containing fresh, non-emulsified SiOs exhibit increased transmittance and decreased reflectance of light within the visible spectrum. Additionally, these eyes demonstrate a higher refractive index.…”

Section: Np112mentioning

confidence: 99%

“…Because SiO does not contain fluorophores that can be stimulated by blue wavelength light, it does not appear hyperautofluorescent. 2,8 The emulsified SiO bubbles appear dark and hypoautofluorescent, effectively blocking the underlying retinal fluorescence.…”

Section: Np112mentioning

confidence: 99%

Multicolour® imaging findings in residual emulsified silicone oil bubbles

Venkatesh,

Joshi,

Choudhary

et al. 2024

European Journal of Ophthalmology

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Purpose To describe the findings of Multicolour® imaging (MCI) in the presence of residual emulsified silicone oil (SiO) droplets. Case report A 62-year-old man had previously undergone surgery for a traumatic retinal detachment in the left eye, followed by SiO removal a few years ago. His presenting visual acuity was 6/60 in the left eye and intraocular pressure was 12 mm Hg. Clinical examination revealed the presence of emulsified residual SiO droplets in the vitreous cavity, ‘inverse hyperoleon’ at the posterior pole and pathological myopia. Retinal findings were documented using optical coherence tomography (OCT), fundus autofluorescence (FAF), and MCI on the Spectralis (Heidelberg, Germany) machine. Results On OCT, the emulsified SiO droplets in the preretinal and intraretinal layers appeared as multiple hyperreflective dots with no underlying shadowing trapped beneath the residual posterior hyaloid or preretinal membrane in the region of the posterior staphyloma. Residual emulsified silicon oil on the retinal surface appeared to have greenish hue on the composite multicolour image and was hyperreflective on individual blue and green reflectance images and dark and hyporeflective on the infrared reflectance image. The SiO droplets appeared dark and were difficult to identify on the short wavelength FAF image. Conclusion To the best of our knowledge, this case report describes the MCI findings in emulsified SiO droplets for the first time.

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“…Dalam pengukuran tersebut diperoleh nilai estimasi viskositas yang masih jauh dibandingkan dengan nilai viskositas sebenarnya. Hal ini dikarenakan silicone oil yang dilarutkan pada cairan BSS tidak larut secara sempurna [5]. Untuk itu, pada penelitian ini dilakukan teknik pengukuran melalui metode pengenceran dengan menggunakan variasi pelarut berupa pelarut organik yaitu kloroform dan toluene.…”

Section: Pendahuluanunclassified

Penentuan Kurva Kalibrasi Untuk Estimasi Viskositas Polydimethylsiloxane (Pdms

Fitrilawati¹

2019

JIIF

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Abstrak. Polydimethylsiloxane (PDMS) (CH3)3SiO-[Si(CH3)2O]n-Si(CH3) yang dikenal juga sebagai silicone oil merupakan salah satu cairan pengganti vitreous humour pada bedah vitreoretinal yang banyak dipakai. Dalam aplikasinya dibutuhkan PDMS dengan berbagai tingkat viskositas agar tidak terjadi emulsifikasi pada vitreous humour. Viskositas merupakan salah satu faktor yang mempengaruhi nilai tegangan permukaan yang berperan untuk menjaga bentuk PDMS ketika diinjeksikan pada mata. Semakin besar nilai viskositas maka akan semakin besar pula tegangan permukaan yang dihasilkan. Pada PDMS dengan viskositas tinggi lebih sulit terjadi emulsifikasi dibandingkan dengan PDMS dengan viskositas rendah. Ketika terdapat substansi lain yang tercampur kedalam PDMS setelah diinjeksikan kemata, maka dapat terjadi penurunan tegangan permukaan PDMS dan terjadi emulsifikasi. Oleh karena itu diperlukan teknik pengukuran viskositas dalam rentang yang cukup lebar agar PDMS dapat disintesis dengan berbagai tingkat kekentalan. Salah satu cara penentuan viskositas adalah melalui kurva kalibrasi yang didapat melalui metode ekstrapolasi. Dalam penelitian ini akan dilaporkan hasil eksperimen pembuatan kurva kalibrasi untuk penentuan nilai viskositas Polydimethylsiloxane (PDMS) dengan teknik pengenceran. Gel PDMS masing-masing dilarutkan dengan pelarut kloroform dan pelarut toluene dengan berbagai konsentrasi. Pengenceran tersebut dimaksudkan untuk mendapatkan beberapa titik ekstrapolasi guna menghasilkan kurva kalibrasi. Hasil kurva kalibrasi yang didapat dipakai untuk menentukan nilai viskositas dari beberapa PDMS hasil sintesis. Kata kunci : Polydimethylsiloxane, vitreous humour, bedah vitreoretinal, emulsifikasi

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Characterization of Optical and Structure Properties of Polydimethylsiloxanes

Cited by 15 publications

References 10 publications

Physical Characterization and In Vitro Toxicity Test of PDMS Synthesized from Low-Grade D4 Monomer as a Vitreous Substitute in the Human Eyes

Physical Characterization and In Vitro Toxicity Test of PDMS Synthesized from Low-Grade D4 Monomer as a Vitreous Substitute in the Human Eyes

Multicolour® imaging findings in residual emulsified silicone oil bubbles

Penentuan Kurva Kalibrasi Untuk Estimasi Viskositas Polydimethylsiloxane (Pdms

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