2022
DOI: 10.21037/atm-22-5613
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Characterization of osteosarcoma subtypes mediated by macrophage-related genes and creation and validation of a risk score system to quantitatively assess the prognosis of osteosarcoma and reflect the tumor microenvironment

Abstract: Background: Macrophages are the main immune components in the microenvironment of osteosarcoma.The treatment strategy centered on macrophages has become a hot topic to improve cancer treatment.However, the research on the role of macrophages in the treatment of osteosarcoma is still in its infancy. Methods:The data of osteosarcoma samples were downloaded from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) and GSE21257 datasets, and the macrophage enrichment fraction of osteos… Show more

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