Characterization of pharmaceuticals, personal care products, and polybrominated diphenyl ethers in lake sturgeon serum and gametes

Banda, Jo A.; Gefell, Dan; An, Viktoriya; Bellamy, Amber R.; Biesinger, Zy; Boase, James C.; Chiotti, Justin A.; Gorsky, Dimitry; Robinson, Timothy J.; Schlueter, Scott; Withers, Jonah L.; Hummel, Stephanie L.

doi:10.1016/j.envpol.2020.115051

Cited by 7 publications

(8 citation statements)

References 77 publications

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“…Additional examination revealed 2-hydroxy-ibuprofen (anti-inflammatory), clonidine (antihypertensives), and melphalan (chemotherapy) elevated concentrations across cluster 1 and cluster 3 are indicative of their incomplete breakdown and release from wastewater treatment processes and medical discharges, since these pharmaceuticals are used extensively to treat cancer, hypertension (e.g., regulate blood pressure), and other related ailments (Ebele et al, 2017 ; Godoy et al, 2015 ; Yadav et al, 2021 ). Overall, this study confirms PPCPs detected in mussels from inshore and offshore sites are similar in complexity and occurrence to other comparative studies that have examined PPCPs throughout the Great Lakes (Baker et al, 2022 ; Banda et al, 2020b ; Choy et al, 2017 ; Custer et al, 2020 ). Equally important, this study further provides evidence of emerging contaminant concentrations and composition strong variations that can occur between inshore and offshore (i.e., open/deep lake) sampling locations.…”

Section: Resultssupporting

confidence: 88%

“…These results indicate that PPCP chemical composition generally differed among MWP sites basin-wide, with some sites experiencing elevated contaminant exposure during the 2013–2018 study period. In addition to this study, several comparative studies have shown PPCPs are also occurring as complex mixtures in surface water (Baker et al, 2022 ; Baldwin et al, 2016 ; Blair et al, 2013 ; Ferguson et al, 2013 ; Pronschinske et al, 2022 ) and tissue samples (i.e., mussels, fish, and tree swallows [ Tachycineta bicolor ]; Banda et al, 2020 ; Cipoletti et al, 2019 ; Custer et al, 2020 ; Deere et al, 2020 ; de Solla et al, 2016 ; Woolnough et al, 2020 ) in the Great Lakes region. As shown in a previous study, the detection of these compounds as complex mixtures in the Great Lakes is of concern, due to their constituents, which were formulated to act on specific molecular targets in humans (Maloney et al, 2022 ).…”

Section: Resultsmentioning

confidence: 84%

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An assessment and characterization of pharmaceuticals and personal care products (PPCPs) within the Great Lakes Basin: Mussel Watch Program (2013–2018)

M. A.,

K.,

et al. 2024

Environ Monit Assess

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Defining the environmental occurrence and distribution of chemicals of emerging concern (CECs), including pharmaceuticals and personal care products (PPCPs) in coastal aquatic systems, is often difficult and complex. In this study, 70 compounds representing several classes of pharmaceuticals, including antibiotics, anti-inflammatories, insect repellant, antibacterial, antidepressants, chemotherapy drugs, and X-ray contrast media compounds, were found in dreissenid mussel (zebra/quagga; Dreissena spp.) tissue samples. Overall concentration and detection frequencies varied significantly among sampling locations, site land-use categories, and sites sampled proximate and downstream of point source discharge. Verapamil, triclocarban, etoposide, citalopram, diphenhydramine, sertraline, amitriptyline, and DEET (N,N-diethyl-meta-toluamide) comprised the most ubiquitous PPCPs (> 50%) detected in dreissenid mussels. Among those compounds quantified in mussel tissue, sertraline, metformin, methylprednisolone, hydrocortisone, 1,7-dimethylxanthine, theophylline, zidovudine, prednisone, clonidine, 2-hydroxy-ibuprofen, iopamidol, and melphalan were detected at concentrations up to 475 ng/g (wet weight). Antihypertensives, antibiotics, and antidepressants accounted for the majority of the compounds quantified in mussel tissue. The results showed that PPCPs quantified in dreissenid mussels are occurring as complex mixtures, with 4 to 28 compounds detected at one or more sampling locations. The magnitude and composition of PPCPs detected were highest for sites not influenced by either WWTP or CSO discharge (i.e., non-WWTPs), strongly supporting non-point sources as important drivers and pathways for PPCPs detected in this study. As these compounds are detected at inshore and offshore locations, the findings of this study indicate that their persistence and potential risks are largely unknown, thus warranting further assessment and prioritization of these emerging contaminants in the Great Lakes Basin. Graphical Abstract

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Section: Resultssupporting

confidence: 88%

Section: Resultsmentioning

confidence: 84%

An assessment and characterization of pharmaceuticals and personal care products (PPCPs) within the Great Lakes Basin: Mussel Watch Program (2013–2018)

M. A.,

K.,

et al. 2024

Environ Monit Assess

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“…DEET was the most frequently detected compound in Lake Balaton and its sub-catchment region correlating with the seasonal application. To prevent insect and mosquito bites, DEET is one of the most frequently used repellents all around the world and is ubiquitously present in aquatic environments such as surface waters and wastewater effluents at a range from 0.003 µg/L to 2.51 µg/L [55][56][57][58][59][60][61]. The potential classification of DEET under Regulation (EC) No.…”

Section: Discussionmentioning

confidence: 99%

Spatiotemporal analysis of multi-pesticide residues in the largest Central European shallow lake, Lake Balaton, and its sub-catchment area

et al. 2022

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Background The present study aimed to gain a comprehensive knowledge of the presence and environmental risks of pesticide and repellent residues in Lake Balaton and its sub-catchment area (Hungary). A unique analysis of 439 active substances and 17 metabolites was carried out on surface waters and one effluent wastewater as the only direct discharge into Lake Balaton from June 2017 until August 2020. Altogether 203 water- and 85 sediment samples were collected and analysed during the 3-year monitoring period. To determine the environmental risks of the detected pesticides to aquatic ecosystems, environmental risk assessment (ERA) was carried out using two approaches (worst- and general-case scenarios). Results Fifty-two pesticides and one insect repellent were detected, of which 26 belonged to herbicides (24 active substances and two metabolites), 15 to fungicides (15 active substances), and 11 to insecticides (eight active substances and three metabolites), of which only nine of the total analysed compounds are listed to be monitored in surface waters with threshold limit values (TLVs). The most frequently detected compounds were terbuthylazine, diethyltoluamide (DEET), desethyl-atrazine, and metolachlor. Glyphosate, aminomethylphosphonic acid (AMPA), and DEET were found with the highest concentrations of 3.0, 2.0, and 1.57 µg/L, respectively. The pesticide exposures were higher during the summer periods indicating a stable seasonal pattern. According to the performed ERA, the calculated Risk Quotients (RQs) indicated 18 compounds with a high level of risk including nine that had been banned for at least a decade. Discussion This study expands knowledge on the spatiotemporal occurrence of pesticides in inland surface waters and highlights the need to consider widening the number of analysed pesticides beyond the European Water Framework Directive (EWFD). According to our results, additional authority and legislation procedures should come into force for pesticides not indexed in the priority European Union Watch List.

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“…For example, monitoring of tissues of dreissenid mussels in the Great Lakes basin supported the notion that PAHs are mostly land‐derived (Kimbrough et al, 2021). Similarly, blood samples taken from lake sturgeon provided information about the occurrence and possible origins of select CECs that might contribute to understanding why sturgeon populations are struggling to recover in the Great Lakes (Banda et al, 2020). For example, studies on juvenile lake sturgeon from a streamside hatchery indicated that although exposure to CECs was occurring, this did not impact thyroid hormone titers enough to affect imprinting in the fish (Hummel et al, 2022).…”

Section: Study Category 3: Occurrence Of Chemical Mixtures and Integr...mentioning

confidence: 99%

Assessing Contaminants of Emerging Concern in the Great Lakes Ecosystem: A Decade of Method Development and Practical Application

Ankley,

Corsi,

Custer

et al. 2023

Environmental Toxicology and Chemistry

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Assessing the ecological risk of contaminants in the field typically involves consideration of a complex mixture of compounds which may or may not be detected via instrumental analyses. Further, there are insufficient data to predict the potential biological effects of many detected compounds, leading to their being characterized as contaminants of emerging concern (CECs). Over the past several years, advances in chemistry, toxicology, and bioinformatics have resulted in a variety of concepts and tools that can enhance the pragmatic assessment of the ecological risk of CECs. The present Focus article describes a 10+‐ year multiagency effort supported through the U.S. Great Lakes Restoration Initiative to assess the occurrence and implications of CECs in the North American Great Lakes. State‐of‐the‐science methods and models were used to evaluate more than 700 sites in about approximately 200 tributaries across lakes Ontario, Erie, Huron, Michigan, and Superior, sometimes on multiple occasions. Studies featured measurement of up to 500 different target analytes in different environmental matrices, coupled with evaluation of biological effects in resident species, animals from in situ and laboratory exposures, and in vitro systems. Experimental taxa included birds, fish, and a variety of invertebrates, and measured endpoints ranged from molecular to apical responses. Data were integrated and evaluated using a diversity of curated knowledgebases and models with the goal of producing actionable insights for risk assessors and managers charged with evaluating and mitigating the effects of CECs in the Great Lakes. This overview is based on research and data captured in approximately about 90 peer‐reviewed journal articles and reports, including approximately about 30 appearing in a virtual issue comprised of highlighted papers published in Environmental Toxicology and Chemistry or Integrated Environmental Assessment and Management. Environ Toxicol Chem 2023;00:1–13. © 2023 SETAC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.

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Characterization of pharmaceuticals, personal care products, and polybrominated diphenyl ethers in lake sturgeon serum and gametes

Cited by 7 publications

References 77 publications

An assessment and characterization of pharmaceuticals and personal care products (PPCPs) within the Great Lakes Basin: Mussel Watch Program (2013–2018)

An assessment and characterization of pharmaceuticals and personal care products (PPCPs) within the Great Lakes Basin: Mussel Watch Program (2013–2018)

Spatiotemporal analysis of multi-pesticide residues in the largest Central European shallow lake, Lake Balaton, and its sub-catchment area

Assessing Contaminants of Emerging Concern in the Great Lakes Ecosystem: A Decade of Method Development and Practical Application

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