Characterization of polymethylmethacrylate microspheres loaded with silver and doxycycline for dental materials applications

Morais, Dayana Campanelli de; Jackson, John K.; Kong, Jong Hoon; Ghaffari, Sahand; Palma‐Dibb, Regina Guenka; Carvalho, Ricardo Marins de; Lange, Dirk; Manso, Adriana Pigozzo

doi:10.1016/j.dental.2022.02.015

Cited by 4 publications

(1 citation statement)

References 57 publications

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“…Furthermore, the polymerization shrinkage occurring at the margins may create a gap at the tooth–resin interface, thus becoming more susceptible to secondary caries [ 8 , 9 ]. The incorporation of antimicrobial additives into the resin has been shown to improve the action against caries-specific microbiological species [ 10 , 11 , 12 , 13 ]. In addition, for long-term clinical applications, these additives must sustain antimicrobial properties while not acting detrimentally on the mechanical, physical, and/or chemical properties of the dental material.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Physicochemical, Mechanical, and Photocatalytic Antibacterial Properties of a Methacrylate-Based Dental Material Loaded with ZnO Nanoparticles

et al. 2022

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While resin-based materials meet the many requirements of a restorative material, they lack adequate, long-lasting antimicrobial power. This study investigated a zinc oxide nanoparticle (ZnO NP)-loaded resin-blend (RB) toward a new antimicrobial photodynamic therapy (aPDT)-based approach for managing dental caries. The results confirmed that up to 20 wt% ZnO NPs could be added without compromising the degree of conversion (DC) of the original blend. The DC achieved for the 20 wt% ZnO NP blend has been the highest reported. The effects on flexural strength (FS), shear bond strength to dentin (SBS), water sorption (WS), solubility (SL), and viability of Streptococcus mutans under 1.35 J/cm2 blue light or dark conditions were limited to ≤20 wt% ZnO NP loading. The addition of up to 20 wt% ZnO NPs had a minimal impact on FS or SBS, while a reduction in the bacteria count was observed. The maximum loading resulted in an increase in SL. Furthermore, 28-day aging in 37 °C water increased the FS for all groups, while it sustained the reduction in bacteria count for the 20 wt% resin blends. Overall, the ZnO NP-loaded resin-based restorative material presents significant potential for use in aPDT.

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Section: Introductionmentioning

confidence: 99%

Exploring the Physicochemical, Mechanical, and Photocatalytic Antibacterial Properties of a Methacrylate-Based Dental Material Loaded with ZnO Nanoparticles

et al. 2022

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Silver‐Nanoparticles‐Based Composites for Antimicrobial Applications: An Update

Manisekaran,

Chettiar,

Marasamy

et al. 2024

ChemistrySelect

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Antimicrobial resistance (AMR), which develops into superbugs, poses a significant challenge to global health leading to 4.95 million deaths in 2019, necessitating the exploration of alternative strategies. AMR is responsible for a significant economic cost estimated by the World Bank, where AMR could result in additional healthcare costs of US$ 1 trillion by 2050. Thus, overcoming these drawbacks is of great importance. Fortunately, the advent of 21st century nanotechnology provides an ample opportunity to develop diverse nanomaterials along with specific functionalization to treat bacteria, fungi, or viruses more effectively with the combination of innovative technologies. Among these, silver nanoparticles (AgNPs) are considered a great boon in the area of AMR, which has a long history of practice. However, in recent years, Ag‐based composites have been designed by scientists to enhance their antimicrobial effects at minimal concentrations, thereby depending on synergism. Thus, in this review, we provide an update on the recent advances in Ag‐based composites with metals, polymers, and carbon for various antimicrobial applications. In addition, we focused on the mechanisms that assist in tackling microbes and the toxicity of AgNPs. Thus, in this review, we highlight the synergistic effects of AgNP‐based composites in combating several microorganisms.

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Exploring the effectiveness of doxycycline in restorative dentistry: a systematic review of in vitro studies

Carneiro,

Prado,

Nogueira

et al. 2024

Odontology

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Characterization of polymethylmethacrylate microspheres loaded with silver and doxycycline for dental materials applications

Cited by 4 publications

References 57 publications

Exploring the Physicochemical, Mechanical, and Photocatalytic Antibacterial Properties of a Methacrylate-Based Dental Material Loaded with ZnO Nanoparticles

Exploring the Physicochemical, Mechanical, and Photocatalytic Antibacterial Properties of a Methacrylate-Based Dental Material Loaded with ZnO Nanoparticles

Silver‐Nanoparticles‐Based Composites for Antimicrobial Applications: An Update

Exploring the effectiveness of doxycycline in restorative dentistry: a systematic review of in vitro studies

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