Characterization of QCM sensor surfaces coated with molecularly imprinted nanoparticles

Reimhult, Kristina; Yoshimatsu, Keiichi; Risveden, Klas; Chen, Si; Ye, Lei; Krozer, Anatol

doi:10.1016/j.bios.2008.02.011

Cited by 109 publications

(56 citation statements)

References 17 publications

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“…Reimhult et al [68] spin-coated MIP nanoparticles suspended in poly(ethylene terephthalate) (PET) solution on a quartz crystal surface to obtain a stable QCM sensor surface. In a more recent work, Hajizadeh et al [69] used hydrogel polymer to crosslink MIP nanoparticles under frozen condition and obtained macroporous nanoparticle cryogels.…”

Section: Mips As Building Blocks For Multifunctional Materialsmentioning

confidence: 99%

Synthetic Strategies in Molecular Imprinting

2015

Molecularly Imprinted Polymers in Biotechnology

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This chapter introduces the basic principle and the synthetic aspects of molecular imprinting. First, the use of a molecular template to guide the location of functional groups inside molecularly imprinted cavities is explained. Three different mechanisms that ensure a molecular template associates with functional monomers or the imprinted polymers, that is, through reversible covalent, noncovalent, and sacrificial covalent bonds, are then described. The main focus is put on noncovalent molecular imprinting using free radical polymerization. The merits of using classical radical polymerization and more sophisticated, controlled radical polymerization are analyzed. After these synthetic chemistry aspects, the chapter continues to discuss the different polymerization processes that can be used to prepare well-defined polymer monoliths, microspheres, and nanoparticles. New top-down processing techniques that produce micro- and nanopatterns of imprinted polymers are also reviewed. The chapter finishes with a brief introduction to using imprinted polymers as building blocks to construct new functional materials and devices, which we consider as one important direction for further development.

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Section: Mips As Building Blocks For Multifunctional Materialsmentioning

confidence: 99%

Synthetic Strategies in Molecular Imprinting

2015

Molecularly Imprinted Polymers in Biotechnology

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“…15 In addition, they can cause selective survival of drug-resistant pathogens which may result in various drug-resistant micro-organisms that would become dominant species in the environment, causing great harm to ecosystems as well as mankind. Because of strong polarity and low volatility, aquatic environments are their primary reservoirs.…”

Section: Reagents For Molecular Imprintingmentioning

confidence: 99%

Recent advances in molecular imprinting technology: current status, challenges and highlighted applications

2011

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Molecular imprinting technology (MIT) concerns formation of selective sites in a polymer matrix with the memory of a template. Recently, molecularly imprinted polymers (MIPs) have aroused extensive attention and been widely applied in many fields, such as solid-phase extraction, chemical sensors and artificial antibodies owing to their desired selectivity, physical robustness, thermal stability, as well as low cost and easy preparation. With the rapid development of MIT as a research hotspot, it faces a number of challenges, involving biological macromolecule imprinting, heterogeneous binding sites, template leakage, incompatibility with aqueous media, low binding capacity and slow mass transfer, which restricts its applications in various aspects. This critical review briefly reviews the current status of MIT, particular emphasis on significant progresses of novel imprinting methods, some challenges and effective strategies for MIT, and highlighted applications of MIPs. Finally, some significant attempts in further developing MIT are also proposed (236 references).

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“…Since their appearance MIPs have been considered in several areas such as chromatographic separations [18] solid-phase extraction [19] or membrane separations [20]. However it is with chemical sensors [21] that MIP demonstrated their full potential. Those allow monitoring targeted compounds in complex environmental matrices in a fast, cheap and accurate way.…”

Section: Introductionmentioning

confidence: 99%

Applications of molecularly imprinted polymers to the analysis and removal of personal care products: A review

Figueiredo

Erny

Santos

et al. 2016

Talanta

145

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Personal-care products (PCPs) involve a variety of chemicals whose persistency along with their constant release into the environment raised concern to their potential impact on wildlife and humans health. Regarded as emergent contaminants, PCPs demonstrated estrogenic activity leading to the need of new methodologies to detect and remove those compounds from the environment.Molecular imprinting starts with a complex between a template molecule and a functional monomer, which is then polymerized in the presence of a cross-linker. After template removal, the polymer will contain specific cavities. Based on a good selectivity towards the template, molecularly imprinted polymers (MIPs) have been investigated as efficient materials for the analysis and extraction of the so called emergent pollutants contaminants.Rather than lowering the limit of detections, the key theoretical advantage of MIP over existing methodologies is the potential to target specific chemicals. This unique feature, sometime named specificity (as synonym to very high selectivity) allows to use cheap, simple and/or rapid quantitative techniques such as fast separation with ultra-violet (UV) detection, sensors or even spectrometric techniques. When a high degree of selectivity is achieved samples extracted with MIPs can be directly analysed without the need of a separation step. However, while some papers clearly demonstrated the specificity of their MIP toward the targeted PCP, such prove is often lacking, especially with real matrices, making it difficult to assess the success of the different approaches.This review paper focusses on the latest development of MIPs for the analysis of personal care products in the environment, with particular emphasis on design, preparation and practical applications of MIPs.3

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Characterization of QCM sensor surfaces coated with molecularly imprinted nanoparticles

Cited by 109 publications

References 17 publications

Synthetic Strategies in Molecular Imprinting

Synthetic Strategies in Molecular Imprinting

Recent advances in molecular imprinting technology: current status, challenges and highlighted applications

Applications of molecularly imprinted polymers to the analysis and removal of personal care products: A review

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