Characterization of spontaneously occurring corneal changes in Wistar rats

Abstract

Spontaneously-occurring changes in the cornea have been periodically observed during routine ophthalmologic examination of various strains of mice and rats. The clinical appearance of these changes has been variably described as corneal opacities, corneal dystrophy, or corneal roughness. The purpose of this study was to characterize corneal changes in Wistar rats by light and transmission electron microscopy (LM and TEM), and x-ray microanalysis.