2019
DOI: 10.1088/1752-7163/ab55c5
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Characterization of standardized breath sampling for off-line field use

Abstract: Due to several sources of potential variability associated with exhaled breath bag sampling procedures for off-line analysis, the Respiration Collector for in vitro Analysis (ReCIVA) sampler was developed. Although designed to improve upon several pitfalls of sampling with exhaled breath bags, the ReCIVA remains a minimally studied research tool. In this manuscript, several attributes of the ReCIVA sampler are investigated among three individual tests, such as background contamination, control software version… Show more

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Cited by 21 publications
(41 citation statements)
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“…Taking into account that the values of ratios between a normalized peak area of the most of VOCs detected in ambient air samples (AA) collected by using Mistral were even more than four times higher than those determined in AA samples simultaneously collected by ReCIVA ( Figure 4 ), further investigations are needed to deepen the sampling performances and technical characteristics of ReCIVA. In fact, these results confirm the preliminary ones obtained by Harshaman et al for the isoprene comparing ReCIVA with Altef Bag and two different ReCIVA devices [ 32 , 33 ]. Although the previously mentioned authors recommended an impractical “in-house” flow calibration for each TD tube type and each ReCIVA bank used for collection, in our opinion, a better and online flow mass control should be installed in a ReCIVA device in order to correct the variability in real time associated with the flow impedance through TD tubes.…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…Taking into account that the values of ratios between a normalized peak area of the most of VOCs detected in ambient air samples (AA) collected by using Mistral were even more than four times higher than those determined in AA samples simultaneously collected by ReCIVA ( Figure 4 ), further investigations are needed to deepen the sampling performances and technical characteristics of ReCIVA. In fact, these results confirm the preliminary ones obtained by Harshaman et al for the isoprene comparing ReCIVA with Altef Bag and two different ReCIVA devices [ 32 , 33 ]. Although the previously mentioned authors recommended an impractical “in-house” flow calibration for each TD tube type and each ReCIVA bank used for collection, in our opinion, a better and online flow mass control should be installed in a ReCIVA device in order to correct the variability in real time associated with the flow impedance through TD tubes.…”
Section: Discussionsupporting
confidence: 91%
“…Although the ReCIVA and Mistral devices represent a significant step toward easy and effective exhaled breath sampling, the cost of these devices is not comparable with exhaled breath bags. Moreover, until now, only two studies focused only on isoprene for ReCIVA [ 32 , 33 ] and none for Mistral were conducted aiming to assess the performances of these devices and their comparability with the most diffuse breath sampling method based on a bag’s use. Therefore, the ambitious aim of this study is to compare, for the first time, three different breath sampling approaches and, more specifically, the whole breath sampling by means Tedlar bags, the end-tidal breath collection using a Mistral sampler, and the simultaneous sampling of the whole and alveolar breath by using ReCIVA.…”
Section: Introductionmentioning
confidence: 99%
“…Thermo-desorption tubes containing Tenax/Carbograph-5TD adsorbents are used to collect the breath samples. The ReCIVA device allows for specific fractions of exhaled breath to be collected in TD tubes through continuous monitoring of pressure and CO 2 levels within the mask and for the removal of background contaminants [ 139 ]. Using Tenax as an absorption material in the sampling process has advantages (such as stability and low desorption temperature) but there are some drawbacks.…”
Section: Limitations Excluding Criteria and Standardizationmentioning
confidence: 99%
“…VOCs emitted from feces are increasingly considered as potential useful markers in diagnostic of different diseases; however, standardization of sampling procedures is still in an incipient phase. Efforts for development of standardized sampling methods were made in different fields of metabolomics, and mostly for the case of breath samples 1 5 . Moreover, for breath analysis various sensors able to perform the analyses in real time, without any pre-concentration or storage, were created in the attempt to diagnose respiratory diseases 6 8 and even a standardized breath sampler was developed 1 .…”
Section: Introductionmentioning
confidence: 99%
“…Efforts for development of standardized sampling methods were made in different fields of metabolomics, and mostly for the case of breath samples 1 5 . Moreover, for breath analysis various sensors able to perform the analyses in real time, without any pre-concentration or storage, were created in the attempt to diagnose respiratory diseases 6 8 and even a standardized breath sampler was developed 1 . Except breath samples, other matrices, such as urine 9 11 , sweat 12 , human tissues 13 , saliva 14 , breast milk 15 , exudates 16 , or bacteria 17 21 were investigated in research articles and discussed in reviews 19 , 22 24 in order to discover valuable biomarkers of certain diseases.…”
Section: Introductionmentioning
confidence: 99%