Characterization of stationary phases based on polysiloxanes thermally immobilized onto silica and metalized silica using supercritical fluid chromatography with the solvation parameter model

Silva, Carla G.A. da; Lesellier, Éric; West, Caroline

doi:10.1016/j.chroma.2013.09.055

Cited by 17 publications

(6 citation statements)

References 34 publications

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“…With the development of technology and the increase in experimental demand, several novel stationary phases are being developed [41][42][43][44][45][46][47][48]. The Chou group [41] covalently bonded 1-octyl-3-propylimidazolium chloride on silica gel to produce an ionic liquidfunctionalized stationary phase.…”

Section: Other Stationary Phasesmentioning

confidence: 99%

Advanced Development of Supercritical Fluid Chromatography in Herbal Medicine Analysis

et al. 2022

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The greatest challenge in the analysis of herbal components lies in their variety and complexity. Therefore, efficient analytical tools for the separation and qualitative and quantitative analysis of multi-components are essential. In recent years, various emerging analytical techniques have offered significant support for complicated component analysis, with breakthroughs in selectivity, sensitivity, and rapid analysis. Among these techniques, supercritical fluid chromatography (SFC) has attracted much attention because of its high column efficiency and environmental protection. SFC can be used to analyze a wide range of compounds, including non-polar and polar compounds, making it a prominent analytical platform. The applicability of SFC for the separation and determination of natural products in herbal medicines is overviewed in this article. The range of applications was expanded through the selection and optimization of stationary phases and mobile phases. We also focus on the two-dimensional SFC analysis. This paper provides new insight into SFC method development for herbal medicine analysis.

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Section: Other Stationary Phasesmentioning

confidence: 99%

Advanced Development of Supercritical Fluid Chromatography in Herbal Medicine Analysis

et al. 2022

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“…Early on, Princeton Chromatography also had a range of other columns with original stationary phases designed for SFC, such as 4‐ethylpyridine, diethylaminopropyl, dinitrophenyl, or benzenesulfonamide . Some academic and industry teams have also developed new stationary phase chemistries for SFC use with pharmaceutical compounds, based on original neutral or ionic liquid ligands . Whether they will yield any commercial product is however unsure yet.…”

Section: Chromatographic Conditions For Sfc Analysis Of Drug Moleculesmentioning

confidence: 99%

Use and practice of achiral and chiral supercritical fluid chromatography in pharmaceutical analysis and purification

Lemasson

Bertin

West

2016

J of Separation Science

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101

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The interest of pharmaceutical companies for complementary high-performance chromatographic tools to assess a product's purity or enhance this purity is on the rise. The high-throughput capability and economic benefits of supercritical fluid chromatography, but also the "green" aspect of CO2 as the principal solvent, render supercritical fluid chromatography very attractive for a wide range of pharmaceutical applications. The recent reintroduction of new robust instruments dedicated to supercritical fluid chromatography and the progress in stationary phase technology have also greatly benefited supercritical fluid chromatography. Additionally, it was shown several times that supercritical fluid chromatography could be orthogonal to reversed-phase high-performance liquid chromatography and could efficiently compete with it. Supercritical fluid chromatography is an adequate tool for small molecules of pharmaceutical interest: synthetic intermediates, active pharmaceutical ingredients, impurities, or degradation products. In this review, we first discuss about general chromatographic conditions for supercritical fluid chromatography analysis to better suit compounds of pharmaceutical interest. We also discuss about the use of achiral and chiral supercritical fluid chromatography for analytical purposes and the recent applications in these areas. The use of preparative supercritical fluid chromatography by pharmaceutical companies is also covered.

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“…However, the limitation of silica-based stationary phases to a restricted pH range between 2 and 8 promoted a growing search for more stable inorganic oxides, mainly in alkaline medium, as supports for RP-LC [2][3][4]. Coating the silica with metal oxide layer was shown to be one of the most successful strategies in the preparation of chromatographic supports and led to the expansion of application field of RP-LC without loss in separation efficiencies [5][6][7][8][9]. More recently, silica coated with alumina has been presented as a chromatographic support that, in addition to greater chemical stability, results in a lower residual activity in separations by HPLC compared to coating with other metallic oxides [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Quantification of Hydroxyl Groups from Alumina in Aluminosilicate Materials by Adsorption Isotherms

Faria¹,

Santos²,

Assunção³

2019

Br J Anal Chem

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A simple and accessible method without the use of expensive and specific reagents is presented in this work for the quantification of hydroxyl groups from alumina in aluminized silica. The method is based on the differential interaction of a dye on bare silica and on aluminized silica surfaces due to the electrostatic repulsion of dye molecules by Al-OH groups in aluminized silica, and subsequent spectrophotometric quantification. The adsorbate molecule used for this study was malachite green. The difference between amount of malachite green retained on bare silica and aluminized silica remained constant when the ratio of active sites on the support to malachite green molecules was not very different. The results indicated that the method presents sensitivity and selectivity for the determination of hydroxyl groups in aluminosilicate materials with high repeatability, making possible the quantification of Al-OH in aluminosilicates without the use of sophisticated scientific instruments.

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Characterization of stationary phases based on polysiloxanes thermally immobilized onto silica and metalized silica using supercritical fluid chromatography with the solvation parameter model

Cited by 17 publications

References 34 publications

Advanced Development of Supercritical Fluid Chromatography in Herbal Medicine Analysis

Advanced Development of Supercritical Fluid Chromatography in Herbal Medicine Analysis

Use and practice of achiral and chiral supercritical fluid chromatography in pharmaceutical analysis and purification

Quantification of Hydroxyl Groups from Alumina in Aluminosilicate Materials by Adsorption Isotherms

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