Characterization of Streptococcus pneumoniae invasive serotype 19A isolates from Argentina (1993–2014)

Gagetti, Paula; Faccone, Diego; Reijtman, Vanesa; Fossati, Sofía; Rodríguez, Marisa; Véliz, Omar; Ceriana, Paola; Regueira, Mabel; Corso, Alejandra

doi:10.1016/j.vaccine.2017.07.030

Cited by 13 publications

(8 citation statements)

References 18 publications

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Section: Resultssupporting

confidence: 91%

“…The most common clinical presentation of IPD by serotype 19A in this analysis was pneumonia, similar to that reported by an Argentinean study, 22 followed by primary bacteremia and meningitis. In the study conducted by the CASPER group (The Calgary Area Streptococcus pneumoniae Epidemiology Research), serotype 19A was a frequent cause of IDP in children under 5 years of age, but unlike our findings, the primary diagnosis in this age group was meningitis (14.2% of IPD).…”

Section: Resultssupporting

confidence: 89%

“…The study provides recent data on the epidemiological and clinical behavior of IPD by serotype 19A in Bogota. We found that serotype 19A is a prevalent cause of IPD in the analyzed pediatric population, mainly in children under 5 years of age, similar to that reported in other studies 2,15,[22][23][24][25][26] We found an increasing trend over time, from 0% in 2008 to 33% in 2017 in those under 18 years of age and from 0% in 2008 to 36.6% in children under 5 years of age, an increase observed especially since 2013. Data from this study are similar to data in children under 5 years published by the INS 25 in which the prevalence increases from 3.5% in 2008 to 43% in 2017.…”

Section: Discussionsupporting

confidence: 90%

“…35,37,38 Hence, it is important to continue an active IPD surveillance program to obtain objective information on their epidemiological behavior and to propose health care measures for these diseases. 39 The most common clinical presentation of IPD by serotype 19A in this analysis was pneumonia, similar to that reported by an Argentinean study, 22 Research), serotype 19A was a frequent cause of IDP in children under 5 years of age, but unlike our findings, the primary diagnosis in this age group was meningitis (14.2% of IPD). 4,12 In the Cassiolato study, 37.7% of the cases were meningitis, and 62.3% were isolates from patients with nonmeningeal pathologies.…”

Section: Discussionsupporting

confidence: 90%

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Emergence of Streptococcus pneumoniae serotype 19A (Spn19A) in the pediatric population in Bogotá, Colombia as the main cause of invasive pneumococcal disease after the introduction of PCV10

Moreno

Imbachi

Leal

et al. 2020

Human Vaccines & Immunotherapeutics

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Introduction : With the use of pneumococcal conjugate vaccines(PCV), the behavior of invasive pneumococcal disease(IPD) has changed relative to serotype distribution. The introduction of these vaccines in national immunization programs has reduced the incidence of IPD, with a marked decrease in the circulation of the serotypes included in the vaccine used in each country. However, the subsequent emergence of other serotypes not included in the vaccine, such 19A in case of PCV7 and PCV10, has been documented. Materials and methods : This was case series study (2008–2017) in pediatric patients admitted to 10 hospitals in Bogota who were diagnosed with IPD. It was conducted during the transitional period of implementing the PCV10 vaccine in Colombia in 2012. Cases of bacteremic pneumococcal pneumonia, meningitis, primary bacteremia and osteoarticular infection were included. A descriptive analysis of the demographic, clinical and laboratory variables of patients with IPD by Spn19A, its trend over time, profiles of antimicrobial susceptibility and clinical outcomes was performed. Results : There were 463 cases of IPD, 315(68%) with known serotypes. The prevalence of IPD by Spn19A was 17.7%(56 cases), tending to increase over time. During 2008–2011, the prevalence was 4.4%, and during 2014–2017, it was 32.4%, The most frequent diagnosis was pneumonia(80.4%). In nonmeningeal isolates, 39.6% were not susceptible to penicillin. An increase in the resistance was observed over time. Conclusion : Spn19A is a prevalent cause of IPD in the pediatric population of the analyzed cohort, with an increasing trend of this serotype during the surveillance period after the introduction of PCV10, being the most common serotype identified in recent years.

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Section: Resultssupporting

confidence: 91%

Section: Resultssupporting

confidence: 89%

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

See 2 more Smart Citations

Emergence of Streptococcus pneumoniae serotype 19A (Spn19A) in the pediatric population in Bogotá, Colombia as the main cause of invasive pneumococcal disease after the introduction of PCV10

Moreno

Imbachi

Leal

et al. 2020

Human Vaccines & Immunotherapeutics

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“…Prior to PCV implementation in South Africa GPSC5 was more common among serotype 23F isolates however there was a shift towards serotype 35B as the main GPSC5 serotype during the PCV13 era. This lineage is usually associated with the PCV serotypes 6A, 6B, 23F and 19A [28–30]. The detection of this lineage within isolates of diverse serotypes is in keeping with the higher than average propensity for recombination as measured using r/m previously (GPSC5 r/m 10.16, average 7.70) [1].…”

Section: Discussionmentioning

confidence: 92%

A Streptococcus pneumoniae lineage usually associated with pneumococcal conjugate vaccine (PCV) serotypes is the most common cause of serotype 35B invasive disease in South Africa, following routine use of PCV

Ndlangisa

Plessis

et al. 2022

Microbial Genomics

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Pneumococcal serotype 35B is an important non-conjugate vaccine (non-PCV) serotype. Its continued emergence, post-PCV7 in the USA, was associated with expansion of a pre-existing 35B clone (clonal complex [CC] 558) along with post-PCV13 emergence of a non-35B clone previously associated with PCV serotypes (CC156). This study describes lineages circulating among 35B isolates in South Africa before and after PCV introduction. We also compared 35B isolates belonging to a predominant 35B lineage in South Africa (GPSC5), with isolates belonging to the same lineage in other parts of the world. Serotype 35B isolates that caused invasive pneumococcal disease in South Africa in 2005–2014 were characterized by whole-genome sequencing (WGS). Multi-locus sequence types and global pneumococcal sequence clusters (GPSCs) were derived from WGS data of 63 35B isolates obtained in 2005–2014. A total of 262 isolates that belong to GPSC5 (115 isolates from South Africa and 147 from other countries) that were sequenced as part of the global pneumococcal sequencing (GPS) project were included for comparison. Serotype 35B isolates from South Africa were differentiated into seven GPSCs and GPSC5 was most common (49 %, 31/63). While 35B was the most common serotype among GPSC5/CC172 isolates in South Africa during the PCV13 period (66 %, 29/44), 23F was the most common serotype during both the pre-PCV (80 %, 37/46) and PCV7 period (32 %, 8/25). Serotype 35B represented 15 % (40/262) of GPSC5 isolates within the global GPS database and 75 % (31/40) were from South Africa. The predominance of the GPSC5 lineage within non-vaccine serotype 35B, is possibly unique to South Africa and warrants further molecular surveillance of pneumococci.

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Genetic diversity of Streptococcus pneumoniae in Tunisia

Midouni

Mehiri

Ghariani

et al. 2019

International Journal of Antimicrobial Agents

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Characterization of Streptococcus pneumoniae invasive serotype 19A isolates from Argentina (1993–2014)

Cited by 13 publications

References 18 publications

Emergence of Streptococcus pneumoniae serotype 19A (Spn19A) in the pediatric population in Bogotá, Colombia as the main cause of invasive pneumococcal disease after the introduction of PCV10

Emergence of Streptococcus pneumoniae serotype 19A (Spn19A) in the pediatric population in Bogotá, Colombia as the main cause of invasive pneumococcal disease after the introduction of PCV10

A Streptococcus pneumoniae lineage usually associated with pneumococcal conjugate vaccine (PCV) serotypes is the most common cause of serotype 35B invasive disease in South Africa, following routine use of PCV

Genetic diversity of Streptococcus pneumoniae in Tunisia

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