Characterization of the influence of age on GABAA and glutamatergic mediated functions in the dorsolateral prefrontal cortex using paired-pulse TMS-EEG

Noda, Yoshihiro; Zomorrodi, Reza; Cash, Robin; Barr, Mera S.; Farzan, Faranak; Rajji, Tarek K.; Chen, Robert; Daskalakis, Zafiris J.; Blumberger, Daniel M.

doi:10.18632/aging.101178

Cited by 49 publications

(34 citation statements)

References 44 publications

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“…Previous research has demonstrated relationship between P60 and N100 (Noda, Zomorrodi, Cash, et al, 2017d). We explored whether there was an association in changes in the amplitude of these peaks following iTBS.…”

Section: Effects Of Itbs On the Relationship Between P60 And N100mentioning

confidence: 94%

“…While it is speculative, the correlations between working memory performance and the ratio of P60 and N100 may partially be explained by the well-maintained modulation of potential inhibition (N100) and excitation (P60) (Noda, Zomorrodi, Cash, et al, 2017d). While it is speculative, the correlations between working memory performance and the ratio of P60 and N100 may partially be explained by the well-maintained modulation of potential inhibition (N100) and excitation (P60) (Noda, Zomorrodi, Cash, et al, 2017d).…”

Section: Relationship Between Neurophysiological Changes and The Chmentioning

confidence: 99%

“…The balance between excitation and inhibition may be more critical to neural function and behaviour than either neural excitability or inhibition alone (Bonansco & Fuenzalida, 2016;Cash, Udupa, et al, 2017d;Meunier, Chameau, & Fossier, 2017;Turrigiano, 2011), and evidence suggests TBS may have an influence in this regulatory property in animal (Moreau, Amar, Callebert, & Fossier, 2013) and humans (Chung, Rogasch, Hoy, Sullivan, et al, 2018b;Hoy et al, 2016;Legon et al, 2016). Therefore, exploratory analyses were performed regarding the relationship between iTBS-induced change in P60 and N100 amplitudes in order to examine whether significant differences in any of the iTBS conditions could reflect altered inhibitory/excitatory balances (Noda, Zomorrodi, Cash, et al, 2017d).…”

Section: Selection Of Individualised Frequencies Of Itbs Based On Tmentioning

confidence: 99%

“…Consequently, the balance in the relationship between the P60 and N100 has been proposed to relate to the balance of neural excitation and inhibition in humans (Noda, Zomorrodi, Cash, et al, 2017d), which is a quintessential property of neural function, and its importance in modulating behavioural function has been demonstrated in animal (Yizhar et al, 2011) and human studies (Lisman, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…This ratio may represent excitation/inhibition balance in the prefrontal cortex(Noda, Zomorrodi, Cash, et al, 2017d) which is important in working memory and network functions(Legon et al, 2016;Rubin, Abbott, & Sompolinsky, 2017), and balanced regulation is required for prefrontal cortex-dependent behaviours(Fan & Hu, 2018). This ratio may represent excitation/inhibition balance in the prefrontal cortex(Noda, Zomorrodi, Cash, et al, 2017d) which is important in working memory and network functions(Legon et al, 2016;Rubin, Abbott, & Sompolinsky, 2017), and balanced regulation is required for prefrontal cortex-dependent behaviours(Fan & Hu, 2018).…”

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confidence: 99%

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The effects of individualised intermittent theta burst stimulation in the prefrontal cortex: A TMS‐EEG study

Chung

Sullivan

Rogasch

et al. 2018

Human Brain Mapping

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Recent studies have highlighted variability in response to theta burst stimulation (TBS) in humans. TBS paradigm was originally developed in rodents to mimic gamma bursts coupled with theta rhythms, and was shown to elicit long‐term potentiation. The protocol was subsequently adapted for humans using standardised frequencies of stimulation. However, each individual has different rhythmic firing pattern. The present study sought to explore whether individualised intermittent TBS (Ind iTBS) could outperform the effects of two other iTBS variants. Twenty healthy volunteers received iTBS over left prefrontal cortex using 30 Hz at 6 Hz, 50 Hz at 5 Hz, or individualised frequency in separate sessions. Ind iTBS was determined using theta‐gamma coupling during the 3‐back task. Concurrent use of transcranial magnetic stimulation and electroencephalography (TMS‐EEG) was used to track changes in cortical plasticity. We also utilised mood ratings using a visual analogue scale and assessed working memory via the 3‐back task before and after stimulation. No group‐level effect was observed following either 30 or 50 Hz iTBS in TMS‐EEG. Ind iTBS significantly increased the amplitude of the TMS‐evoked P60, and decreased N100 and P200 amplitudes. A significant positive correlation between neurophysiological change and change in mood rating was also observed. Improved accuracy in the 3‐back task was observed following both 50 Hz and Ind iTBS conditions. These findings highlight the critical importance of frequency in the parameter space of iTBS. Tailored stimulation parameters appear more efficacious than standard paradigms in neurophysiological and mood changes. This novel approach presents a promising option and benefits may extend to clinical applications.

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Section: Effects Of Itbs On the Relationship Between P60 And N100mentioning

confidence: 94%

Section: Relationship Between Neurophysiological Changes and The Chmentioning

confidence: 99%

Section: Selection Of Individualised Frequencies Of Itbs Based On Tmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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The effects of individualised intermittent theta burst stimulation in the prefrontal cortex: A TMS‐EEG study

Chung

Sullivan

Rogasch

et al. 2018

Human Brain Mapping

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Regional Precuneus Cortical Hyperexcitability in Alzheimer's Disease Patients

Casula

Borghi

Maiella

et al. 2022

Annals of Neurology

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Objective Neuronal excitation/inhibition (E/I) imbalance is a potential cause of neuronal network malfunctioning in Alzheimer's disease (AD), contributing to cognitive dysfunction. Here, we used a novel approach combining transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to probe cortical excitability in different brain areas known to be directly involved in AD pathology. Methods We performed TMS‐EEG recordings targeting the left dorsolateral prefrontal cortex (l‐DLPFC), the left posterior parietal cortex (l‐PPC), and the precuneus (PC) in a large sample of patients with mild‐to‐moderate AD (n = 65) that were compared with a group of age‐matched healthy controls (n = 21). Results We found that patients with AD are characterized by a regional cortical hyperexcitability in the PC and, to some extent, in the frontal lobe, as measured by TMS‐evoked potentials. Notably, cortical excitability assessed over the l‐PPC was comparable between the 2 groups. Furthermore, we found that the individual level of PC excitability was associated with the level of cognitive impairment, as measured with Mini‐Mental State Examination, and with corticospinal fluid levels of Aβ42. Interpretation Our data provide novel evidence that precuneus cortical hyperexcitability is a key feature of synaptic dysfunction in patients with AD. The current results point to the combined approach of TMS and EEG as a novel promising technique to measure hyperexcitability in patients with AD. This index could represent a useful biomarker to stage disease severity and evaluate response to novel therapies. ANN NEUROL 2023;93:371–383

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Noninvasive Brain Stimulation to Reduce Falls in Older Adults

Manor

Zhou

et al. 2019

Falls and Cognition in Older Persons

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Characterization of the influence of age on GABAA and glutamatergic mediated functions in the dorsolateral prefrontal cortex using paired-pulse TMS-EEG

Cited by 49 publications

References 44 publications

The effects of individualised intermittent theta burst stimulation in the prefrontal cortex: A TMS‐EEG study

The effects of individualised intermittent theta burst stimulation in the prefrontal cortex: A TMS‐EEG study

Regional Precuneus Cortical Hyperexcitability in Alzheimer's Disease Patients

Noninvasive Brain Stimulation to Reduce Falls in Older Adults

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