Characterization of the release profile of doxycycline by PLGA microspheres adjunct to non-surgical periodontal therapy

Moura, Lucas de Almeida; Ribeiro, Fernanda Vieira; Aiello, T.B.; Duek, Eliana Ap. De Rezende; Sallum, Enílson Antônio; Nociti, Francisco Humberto; Casati, Márcio Zaffalon; Sallum, Antônio Wilson

doi:10.1080/09205063.2015.1045249

Cited by 29 publications

(20 citation statements)

References 46 publications

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“…12 Ten-percent DOX gel has been used in the treatment of periodontitis and has been proven to more effectively reduce the periodontal probing depth (PPD) and improve the clinical attachment level (CAL) compared with SRP alone, thereby improving the quality of life of individuals with periodontitis. 13,14,15 However, Garrett et al 16 reported that the treatment of moderate to severe periodontitis with 10% DOX was only as effective as SRP.…”

Section: Introductionmentioning

confidence: 99%

Doxycycline encapsulated in β-cyclodextrin for periodontitis: a clinical trial

et al. 2019

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This clinical trial compared the efficacy of doxycycline (DOX) in β-cyclodextrin (DOX)/βCD) with DOX-alone in gel on thirty-three subjects with periodontitis. Patients were randomized to group 1 GI; 10% DOX + scaling and root planning (SRP); group 2 (GII (10% DOX /β-CD + SRP), and group 3 (GIII; SRP). Gels were applied in GI and GII at baseline (T0) and 30 days later (T1). Periodontal Probing Depth (PPD), Clinical Attachment Level (CAL), Bleeding on Probing (BOP) and Visible Plaque Index (VPI) were evaluated at (T0), 30 days (T1) and 60 days after T0 (T2). Bone density was analyzed after 18 months (T3). GII showed the most significant reduction of PPD (2.62 mm; p <0.003), and greatest gain in CAL (2.54 mm p <0.003) at T2. BOP and the VPI had a strong reduction in all groups at T2 (p <0.05), both decreased by ≥5 times and 2 times, respectively, in all groups at T1. Bone density increased in all groups in radiographs (T3). The use of DOX encapsulated in β-CD gel with SRP resulted in significant improvements in clinical periodontal parameters; such molecular inclusion of doxycycline into β-CD in gel for local application is relatively simple and useful in dentistry.

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Section: Introductionmentioning

confidence: 99%

Doxycycline encapsulated in β-cyclodextrin for periodontitis: a clinical trial

et al. 2019

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“…Polymers like polylactides (PLA), polyglycolides (PGA), poly lactide-co-glycolides (PLGA), are approved by the World Health Organization (WHO) and Food and Drug Administration (FDA) as materials that can be used in medicine and pharmacy [28] . Moura et al, demonstrated a successful sustained release of locally delivered doxycycline by poly lactide-co-glycolide (PLGA) microspheres in the periodontal pocket of patients with chronic periodontitis treated by non-surgical periodontal therapy [29] .…”

Section: Discussionmentioning

confidence: 99%

Comparison Between Local Application of Doxycycline Loaded Nanoparticles and Conventional Doxycycline Gel on Matrix Metalloproteinase 1 and Bone Density in Chronic Periodontitis

Elgendy

2017

Egyptian Dental Journal

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Background & Objective: Nanoparticles have received considerable attention in recent years. This study was conducted to compare between doxycycline loaded nanoparticles (DLNs) and conventional doxycycline gel (CDG) in management of chronic periodontitis (CP). Materials and Methods: This randomized, split mouth study was conducted on 40 sites among 20 patients with chronic periodontitis. The sites were randomly allocated into a control group, receiving scaling and root planing (SRP) plus CDG, and an experimental group, receiving SRP plus DLNs. Clinical parameters and levels of matrix metalloproteinase 1 (MMP1) were assessed at baseline, 1, 3 and 6 months post treatment. Bone density was also assessed at baseline and 6 months after treatment. Results: The results, following the use of both treatment gel formulas, showed a statistically significant reduction in all tested clinical parameters and levels of MMP1 at 1, 3 and 6 months post treatment along with significant increase in bone density after 6 months. However, DLNs treatment achieved a significant reduction not only in clinical parameters but also in MMP1 as compared to CDG treated group. In addition, The DLNs showed a significant bone formation as compared to CDG group. Conclusion: DLNs shows promise as adjunctive local therapy for management of patients with chronic periodontitis. Clinical Relevance: Scientific Rationale for Study: Evaluating the effect of doxycycline loaded nanoparticles gel and conventional doxycycline gel on treatment of chronic periodontitis. Principal Findings: Findings from this randomized, split mouth study of 40 sites among 20 patients with chronic periodontitis supported the potential of doxycycline loaded nanoparticles and conventional doxycycline gel for providing an effective therapy for chronic periodontitis, along with improving clinical parameter, bone density and decreasing matrix metalloproteinase 1. Practical Implications: Doxycycline loaded nanoparticles are proved to be more effective than conventional doxycycline gel as an adjunctive treatment of chronic periodontitis.

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“…Nowadays, various antimicrobial agents have been loaded into different dosage forms to prolong their persistence time in periodontal tissue. Tetracycline group antibiotics, including doxycycline hydrochloride [36,117,125], tetracycline [132,133], and minocycline [122,124]; nitroimidazoles antibiotics like metronidazole [116,120] and tinidazole [55] are mostly used. Other antibiotics like quinolones have also been reported (Figure 5a).…”

Section: Anti-bacterial Dds For Periodontitismentioning

confidence: 99%

“…With the application of nanotechnology, micro/nano-scaled carriers are reported in the DDS for oral diseases, which is more comfortable and multifunctional [34]. The carriers could be designed and modified for the loading of anti-bacterial agents [35][36][37], anti-inflammatory drugs [38], and biomolecules like protein and gene, growth factors, which expanded the application of DDS in oral diseases [39][40][41]. These nano-scaled DDS are combined with dental materials like dental restoration systems and dental implants for anti-bacterial modification without affecting their basic properties [42,43].…”

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confidence: 99%

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

et al. 2020

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The oral cavity is a unique complex ecosystem colonized with huge numbers of microorganism species. Oral cavities are closely associated with oral health and sequentially with systemic health. Many factors might cause the shift of composition of oral microbiota, thus leading to the dysbiosis of oral micro-environment and oral infectious diseases. Local therapies and dental hygiene procedures are the main kinds of treatment. Currently, oral drug delivery systems (DDS) have drawn great attention, and are considered as important adjuvant therapy for oral infectious diseases. DDS are devices that could transport and release the therapeutic drugs or bioactive agents to a certain site and a certain rate in vivo. They could significantly increase the therapeutic effect and reduce the side effect compared with traditional medicine. In the review, emerging recent applications of DDS in the treatment for oral infectious diseases have been summarized, including dental caries, periodontitis, peri-implantitis and oral candidiasis. Furthermore, oral stimuli-responsive DDS, also known as "smart" DDS, have been reported recently, which could react to oral environment and provide more accurate drug delivery or release. In this article, oral smart DDS have also been reviewed. The limits have been discussed, and the research potential demonstrates good prospects.Molecules 2020, 25, 516 2 of 29 problems. For example, systemic antibiotics such as tetracycline, beta-lactam antibiotics, nitroimidazoles have been used, especially in cases of periodontal diseases and peri-implantitis [12]. However, systemic antibiotics could cause problems like drug resistance, dysbacteriosis, and systemic side effects [13,14]. The antibacterial effect is also limited as very little could arrive at the oral lesion area after systemic circulation [15][16][17]. Fluoride in drinking water has been used for the prevention of dental caries but might cause excessive intake, leading to fluorosis [18]. Therefore, local drug therapy is now more considered for oral infectious diseases [19,20]. However, the conventional forms of local therapy, like drug suspension or rinse of anti-infection agents, could be easily washed off and thus could not last long in the oral cavity. Complex local lesions like deep periodontal pockets and teeth fissure are also difficult to reach. In order to improve the effect of prophylaxis and treatment, more precise targeting therapy is quite essential [21,22]. Therefore, drug delivery systems have drawn great attention in recent decades in oral infectious diseases. Drug delivery systems (DDS) are devices that can transport and release the therapeutic agents or bioactive substances to certain sites at certain rates in vivo [23,24], usually composed of the carriers and associated therapeutics [25]. They have been widely explored in biomedical research. With local drug administration and controlled drug release, DDS could provide higher curative efficiency and fewer side effects [23,26,27]. With all these advantages, DDS has been reported w...

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Characterization of the release profile of doxycycline by PLGA microspheres adjunct to non-surgical periodontal therapy

Cited by 29 publications

References 46 publications

Doxycycline encapsulated in β-cyclodextrin for periodontitis: a clinical trial

Doxycycline encapsulated in β-cyclodextrin for periodontitis: a clinical trial

Comparison Between Local Application of Doxycycline Loaded Nanoparticles and Conventional Doxycycline Gel on Matrix Metalloproteinase 1 and Bone Density in Chronic Periodontitis

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

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