Characterization of the size, shape, and state of dispersion of nanoparticles for toxicological studies

Powers, Kevin; Palazuelos, Maria; Moudgil, Brij M.; Roberts, Stephen M.

doi:10.1080/17435390701314902

Cited by 327 publications

(180 citation statements)

References 20 publications

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“…The change in surface-to-volume ratio also affects the surface energy and hence reactivity of the material. In addition to surface reactivity, the interaction of ENMs with living systems, the uptake and deposition of ENMs within the human body are also affected by particle size (Powers et al, 2007). It is generally believed that the risk posed by materials containing nano-sized particles increases with decreasing particle size (Monteiro-Riviere & Tran, 2007).…”

Section: Particle Size and Size Distributionmentioning

confidence: 99%

“…There are three important criteria that should be met for accurate measurement of particle size: a well-dispersed system, selection of representative sample and appropriate selection of sizing method considering the nature of ENM and its intended use (Kevin W. Powers, Palazuelos, Moudgil, & Roberts, 2007). It should also be kept in mind that some methods such as DLS, NPTA and DSC require dispersion.…”

Section: Particle Size and Size Distributionmentioning

confidence: 99%

“…(Poland, et al, 2008) have showed that long MWCNTs are more toxic than short/tangled MWCNTs. The study undertaken by (Kevin W. Powers, et al, 2007) has revealed that the antibacterial activity of silver NPs is shape-dependant. In another study, (Gratton, et al, 2008) have demonstrated that rod-like (high aspect ratio) NPs are drawn or internalized more efficiently into the cell than cylinder NPs.…”

Section: Particle Shapementioning

confidence: 99%

“…Therefore, the development of reliable nano-(Q)SAR models requires in situ and careful characterization of ENMs in a relevant biological environment by taking into account the possible impacts of nano-bio interactions on the basic properties (i.e. particle size, aggregation state and coating) of ENMs (Powers et al, 2007). In order to be able to draw certain conclusions about the properties influencing the toxicity of ENMs, it is critical to adequately define time and media dependent nano-characteristics.…”

Section: Final Remarksmentioning

confidence: 99%

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(Q)SAR modelling of nanomaterial toxicity: A critical review

et al. 2015

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There is an increasing recognition that nanomaterials pose a risk to human health, and that the novel engineered nanomaterials (ENMs) in the nanotechnology industry and their increasing industrial usage poses the most immediate problem for hazard assessment, as many of them remain untested. The large number of materials and their variants (different sizes and coatings for instance) that require testing and ethical pressure towards non-animal testing means that expensive animal bioassay is precluded, and the use of (quantitative) structure activity relationships ((Q)SAR) models as an alternative source of hazard information should be explored.(Q)SAR modelling can be applied to fill the critical knowledge gaps by making the best use of existing data, prioritize physicochemical parameters driving toxicity, and provide practical solutions to the risk assessment problems caused by the diversity of ENMs. This paper covers the core components required for successful application of (Q)SAR technologies to ENMs toxicity prediction, and summarizes the published nano-(Q)SAR studies and outlines the challenges ahead for nano-(Q)SAR modelling. It provides a critical review of (1) the present status of the availability of ENMs characterization/toxicity data, (2) the characterization of nanostructures that meets the need of (Q)SAR analysis, (3) the summary of published nano-(Q)SAR studies and their limitations, (4) the in silico tools for (Q)SAR screening of nanotoxicity and (5) the prospective directions for the development of nano-(Q)SAR models.

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Section: Particle Size and Size Distributionmentioning

confidence: 99%

Section: Particle Size and Size Distributionmentioning

confidence: 99%

Section: Particle Shapementioning

confidence: 99%

Section: Final Remarksmentioning

confidence: 99%

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(Q)SAR modelling of nanomaterial toxicity: A critical review

et al. 2015

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“…A more extensive and complete characterization, including size distribution, shape, surface area, surface chemistry, crystallinity, porosity, agglomeration state, surface charge, solubility, etc., is recommended for nanomaterials in order to determine the correct correlation between their physicochemical properties and the biological effects they elicit [43][44][45][46].…”

Section: Se Nanoparticles Characterization [42]mentioning

confidence: 99%

Green Synthesis of Selenium Nanoparticles from Broccoli, Characterization, Application and Toxicity

Kapur¹,

Soni²,

Kohli³

2017

Adv Tech Biol Med

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Selenium in broccoliBroccoli belongs to the Brassicaceae family, originated in the Mediterranean regions and distributed in Europe and in the United States. Broccoli is rich in micronutrients such as carotene, vitamin C and folic acid-fibers, phytochemicals such as glucosinolates (GLs) and *Corresponding author: Kanchan Kohli, PhD, Associate Professor, Department of Pharmaceutics, Jamia Hamdard, Hamdard University, New Delhi 110062, India, Tel: +911126059688; E-mail: drkanchankohli@gmail.com AbstractPlant-based diets and phytochemicals present in plants can be used to decrease the risk of cancer. This article deals with Brassica species and broccoli in particular which are associated with reduced risk of several important cancers. These plants mainly contain selenium (Se) covalently bound in a number of different chemical forms which is mainly responsible for its biological activity. Further, several enzymes contain selenium in the form of the unusual selenocysteine amino acid which act on free radicals. Broccoli has the ability to accumulate Se many-fold beyond the concentration of Se present in the soil. Reflecting on the above it can be suggested that development of methods to increase the natural accumulation of Se in broccoli may greatly enhance its health-promoting properties. The present article details about green synthesis of selenium nanoparticles and their methods of characterizations. Green synthesis is a biological procedure which can be achieved can be achieved by using plant extracts. This method is capable of producing SeNPs in a size range of about 50-150 nm, under ambient conditions. It was found that SeNPs are able to inhibit the cell growth by dose-dependent manner. In addition, combination of SeNPs and doxorubicin shows better anticancer effect than individual treatments. The present review also brings to light about the causes and implications of toxic effects posed by Se nanoparticles as well as applications of Se nanoparticles in medicine.Green Synthesis of Selenium Nanoparticles from Broccoli, Characterization, Application and Toxicity Citation: Kapur M, Soni K, Kohli K (2017) Green Synthesis of Selenium Nanoparticles from Broccoli, Characterization, Application and Toxicity. Adv Tech Biol Med 5: 198. doi: 10.4172/2379-1764.1000198 Page 2 of 7 ManaviVolume Se Nanoparticles Characterization [42]An initial characterization of the test substance is imperative before any toxicity screening is commenced. A more extensive and complete characterization, including size distribution, shape, surface area, surface chemistry, crystallinity, porosity, agglomeration state, surface charge, solubility, etc., is recommended for nanomaterials in order to determine the correct correlation between their physicochemical properties and the biological effects they elicit [43][44][45][46].

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Occupational Health Hazards of Nanoparticles

O’Shaughnessy

2008

Nanoscience and Nanotechnology

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Characterization of the size, shape, and state of dispersion of nanoparticles for toxicological studies

Cited by 327 publications

References 20 publications

(Q)SAR modelling of nanomaterial toxicity: A critical review

(Q)SAR modelling of nanomaterial toxicity: A critical review

Green Synthesis of Selenium Nanoparticles from Broccoli, Characterization, Application and Toxicity

Occupational Health Hazards of Nanoparticles

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