Characterization of the Solution Degradation Products of Etintidine, An H2-Receptor Antagonist

Ti-amide Catalyzed Synthesis of Cyclic Guanidines from Di-/Triamines and Carbodiimides

“…Therefore, their synthesis has been extensively explored. Generally, the known methods include (1) the reactions of amines with S , S -dimethyl- N -tosyliminodithiocarbonimidates, dimethyl cyanoimido-dithiocarbonates, isothiocyanates, − or carbon disulfide; (2) cyclization of guanidino-alkynes; (3) intramolecular alkylation of guanidines; (4) reactions of unsaturated molecules with azridines, and so forth . Very recently, oxidative amination and radical cascade cyclization methods were also successfully applied to the synthesis of cyclic guanidines .…”

Synthesis of Bicyclic Guanidines via Cascade Hydroamination/Michael Additions of Mono-N-acryloylpropargylguanidines

“…Unnatural polycyclic guanidines have also been employed as competent organocatalysts with unique coordination arrangements and an array of donor/acceptors. , Given their broad utility, a variety of synthetic methods have been developed to access this class of compounds. Some of these methods include the cyclization of propargylguanidines, intermolecular diamination of alkenes, reaction of unsaturated molecules with aziridines and diazirenes, intramolecular alkylation of guanidines, and radical cascade cyclizations, among others . Very recently, titanium amides have been shown to catalyze the synthesis of cyclic guanidines from diamines and carbodiimides in a single step .…”