Characterization of Thymoquinone Binding to Human α1-Acid Glycoprotein

Lupidi, Giulio; Camaioni, Emidio; Khalifé, Hamal; Avenali, Luca; Damiani, Elisabetta; Tanfani, Fabio; Scirè, Andrea

doi:10.1002/jps.23138

Cited by 26 publications

(13 citation statements)

References 50 publications

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“…The plasma concentration of glibenclamide increases through the coadministration of TQ as single and multiple doses, respectively [ 64 ]. In addition, TQ binds with major plasma proteins including bovine serum albumin (BSA) and alpha-1 acid glycoprotein (AGP) [ 65 – 68 ]. Molecular modeling and fluorescence quenching studies have confirmed the binding interaction of TQ with BSA and AGP [ 65 , 66 ].…”

Section: Pharmacokinetics and Toxicity Of Thymoquinonementioning

confidence: 99%

“…In addition, TQ binds with major plasma proteins including bovine serum albumin (BSA) and alpha-1 acid glycoprotein (AGP) [ 65 – 68 ]. Molecular modeling and fluorescence quenching studies have confirmed the binding interaction of TQ with BSA and AGP [ 65 , 66 ]. Through covalent bonding, TQ binds to both BSA and AGP.…”

Section: Pharmacokinetics and Toxicity Of Thymoquinonementioning

confidence: 99%

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Neuropharmacological Potential and Delivery Prospects of Thymoquinone for Neurological Disorders

Jakaria

Cho

Haque

et al. 2018

Oxidative Medicine and Cellular Longevity

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Thymoquinone (TQ) is an active ingredient isolated from Nigella sativa and has various pharmacological activities, such as protection against oxidative stress, inflammation, and infections. In addition, it might be a potential neuropharmacological agent because it exhibits versatile potential for attenuating neurological impairments. It features greater beneficial effects in toxin-induced neuroinflammation and neurotoxicity. In various models of neurological disorders, it demonstrates emergent functions, including safeguarding various neurodegenerative diseases and other neurological diseases, such as stroke, schizophrenia, and epilepsy. TQ also has potential effects in trauma mediating and chemical-, radiation-, and drug-induced central nervous system injuries. Considering the pharmacokinetic limitations, research has concentrated on different TQ novel formulations and delivery systems. Here, we visualize the neuropharmacological potential, challenges, and delivery prospects of TQ, specifically focusing on neurological disorders along with its chemistry, pharmacokinetics, and toxicity.

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Section: Pharmacokinetics and Toxicity Of Thymoquinonementioning

confidence: 99%

Section: Pharmacokinetics and Toxicity Of Thymoquinonementioning

confidence: 99%

Neuropharmacological Potential and Delivery Prospects of Thymoquinone for Neurological Disorders

Jakaria

Cho

Haque

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…[75] In addition to these drugs, molecular docking models of imatinib, 6-mercaptopurine and thymoquinone, -AGP variants complex have also been developed. [76][77][78] CD and fluorescence spectrometry is also a useful tool for examining the drug-binding sites of AGP. We found that electrostatic and hydrophobic forces have an important role in interactions between AGP and basic drugs.…”

Section: Drug-binding Propertiesmentioning

confidence: 99%

Molecular Aspects of Human Alpha-1 Acid Glycoprotein — Structure and Function

Taguchi¹,

Nishi²,

Chuang³

et al. 2013

Acute Phase Proteins

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“…Hence, Lupidi et al . [3738] reported the binding interaction of TQ with human serum albumin and Alpha-1 acid glycoprotein (AGP). This was confirmed by using the molecular modeling as well as Fluorescence quenching studies.…”

Section: Review and Discussionmentioning

confidence: 99%

Thymoquinone in the clinical treatment of cancer: Fact or fiction?

AbuKhader

2013

Phcog Rev

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Thymoquinone (TQ) is the bioactive phytochemical constituent of the seeds oil of Nigella sativa. In vitro and in vivo research has thoroughly investigated the anticancer effects of TQ against several cancer cell lines and animal models. As a result, a considerable amount of information has been generated from research thus providing a better understanding of the anti-proliferating activity of this compound. Therefore, it is appropriate that TQ should move from testing on the bench to clinical experiments. The purpose of this review is to highlight the potential of TQ as an anticancer agent and the chances of this compound in the clinical treatment of cancer, with special attention on breast cancer treatment.

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Characterization of Thymoquinone Binding to Human α1-Acid Glycoprotein

Cited by 26 publications

References 50 publications

Neuropharmacological Potential and Delivery Prospects of Thymoquinone for Neurological Disorders

Neuropharmacological Potential and Delivery Prospects of Thymoquinone for Neurological Disorders

Molecular Aspects of Human Alpha-1 Acid Glycoprotein — Structure and Function

Thymoquinone in the clinical treatment of cancer: Fact or fiction?

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