Characterization of X-Ray Acoustic Computed Tomography for Applications in Radiotherapy Dosimetry

Hickling, Susannah; Hobson, Maritza A.; Naqa, Issam El

doi:10.1109/trpms.2018.2801724

Cited by 21 publications

(29 citation statements)

References 17 publications

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“…Besides, the x‐ray pulse profile should also be taken into consideration, since the current duration of the x‐ray beam pulse is too long to be treated as a delta function . According to the previous studies, limited by the 0.5‐MHz central frequency transducer and by the 4‐μs duration of the x‐ray pulse, a theoretical spatial resolution of 6 mm in static image can be achieved and x‐ray field shifts of 2 mm can be determined by our prototype system. When possible, decreasing the duration of the x‐ray pulse and maintaining the dose amount per pulse from the Linac could enhance both the spatial resolution and the signal‐to‐noise ratio (SNR), which is also described in Eq.…”

Section: Discussionmentioning

confidence: 89%

“…Recently, the detection of XA signals in clinical Linacs has been demonstrated, and the XA computed tomography (XACT) imaging of a lead rod embedded in chicken breast tissue has been achieved . Lately, the ability to form experimental XACT images in pure water in a variety of clinically relevant situations and to extract accurate dosimetric information from such images was also demonstrated . Besides the studies working with high‐dose x ray generated by Linacs, XACT imaging based on the kV x‐ray excitations has been explored .…”

Section: Introductionmentioning

confidence: 99%

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Toward in vivo dosimetry in external beam radiotherapy using x‐ray acoustic computed tomography: A soft‐tissue phantom study validation

et al. 2018

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Toward in vivo dosimetry in external beam radiotherapy using x‐ray acoustic computed tomography: A soft‐tissue phantom study validation

et al. 2018

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“…There is a linear relationship between deposited dose and induced pressure in a homogeneous medium. Additionally, XACT is dependent on the dose deposited per pulse, meaning it can be considered energy and dose rate independent . Also, XACT does not perturb the radiation beam provided the transducers are placed outside the beam path.…”

Section: Linac Photon Beam Dosimetrymentioning

confidence: 99%

“…A subsequent XACT characterization study demonstrated that XACT images of acceptable SNR can be formed at a dose level as low as 11.6 mGy, and that changes in field size of 4 mm, field location of 2 mm, and field magnitude of 3% are detectable with the above implementation of XACT. 37 These latest studies demonstrated the viability of using XACT as a relative water tank dosimetry technique in a clinical radiotherapy environment.…”

Section: B Recent Workmentioning

confidence: 99%

“…Additionally, XACT is dependent on the dose deposited per pulse, meaning it can be considered energy and dose rate independent. 37 Also, XACT does not perturb the radiation beam provided the transducers are placed outside the beam path. These features of XACT simplify calibration and eliminate the need for many of the correction factors required by other dosimetry techniques.…”

Section: C Future Outlookmentioning

confidence: 99%

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Ionizing radiation‐induced acoustics for radiotherapy and diagnostic radiology applications

et al. 2018

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Acoustic waves are induced via the thermoacoustic effect in objects exposed to a pulsed beam of ionizing radiation. This phenomenon has interesting potential applications in both radiotherapy dosimetry and treatment guidance as well as low-dose radiological imaging. After initial work in the field in the 1980s and early 1990s, little research was done until 2013 when interest was rejuvenated, spurred on by technological advances in ultrasound transducers and the increasing complexity of radiotherapy delivery systems. Since then, many studies have been conducted and published applying ionizing radiation-induced acoustic principles into three primary research areas: Linear accelerator photon beam dosimetry, proton therapy range verification, and radiological imaging. This review article introduces the theoretical background behind ionizing radiation-induced acoustic waves, summarizes recent advances in the field, and provides an outlook on how the detection of ionizing radiationinduced acoustic waves can be used for relative and in vivo dosimetry in photon therapy, localization of the Bragg peak in proton therapy, and as a low-dose medical imaging modality. Future prospects and challenges for the clinical implementation of these techniques are discussed.

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X‐ray‐induced acoustic computed tomography for guiding prone stereotactic partial breast irradiation: a simulation study

et al. 2020

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The aim of this study is to investigate the feasibility of x-ray-induced acoustic computed tomography (XACT) as an image guidance tool for tracking x-ray beam location and monitoring radiation dose delivered to the patient during stereotactic partial breast irradiation (SPBI). Methods: An in-house simulation workflow was developed to assess the ability of XACT to act as an in vivo dosimetry tool for SPBI. To evaluate this simulation workflow, a three-dimensional (3D) digital breast phantom was created by a series of two-dimensional (2D) breast CT slices from a patient. Three different tissue types (skin, adipose tissue, and glandular tissue) were segmented and the postlumpectomy seroma was simulated inside the digital breast phantom. A treatment plan was made with three beam angles to deliver radiation dose to the seroma in breast to simulate SPBI. The three beam angles for 2D simulations were 17°, 90°and 159°(couch angles were 0 degrees) while the angles were 90 degrees (couch angles were 0°, 27°, 90°) in 3D simulation. A multi-step simulation platform capable of modelling XACT was developed. First, the dose distribution was converted to an initial pressure distribution. The propagation of this pressure disturbance in the form of induced acoustic waves was then modeled using the k-wave MATLAB toolbox. The waves were then detected by a hemispherical-shaped ultrasound transducer array (6320 transducer locations distributed on the surface of the breast). Finally, the time-varying pressure signals detected at each transducer location were used to reconstruct an image of the initial pressure distribution using a 3D time-reversal reconstruction algorithm. Finally, the reconstructed XACT images of the radiation beams were overlaid onto the structure breast CT. Results: It was found that XACT was able to reconstruct the dose distribution of SPBI in 3D. In the reconstructed 3D volumetric dose distribution, the average doses in the GTV (Gross Target Volume) and PTV (Planning Target Volume) were 86.15% and 80.89%, respectively. When compared to the treatment plan, the XACT reconstructed dose distribution in the GTV and PTV had a RMSE (root mean square error) of 2.408 % and 2.299 % over all pixels. The 3D breast XACT imaging reconstruction with time-reversal reconstruction algorithm can be finished within several minutes. Conclusions: This work explores the feasibility of using the novel imaging modality of XACT as an in vivo dosimeter for SPBI radiotherapy. It shows that XACT imaging can provide the x-ray beam location and dose information in deep tissue during the treatment in real time in 3D. This study lays the groundwork for a variety of future studies related to the use of XACT as a dosimeter at different cancer sites.

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Characterization of X-Ray Acoustic Computed Tomography for Applications in Radiotherapy Dosimetry

Cited by 21 publications

References 17 publications

Toward in vivo dosimetry in external beam radiotherapy using x‐ray acoustic computed tomography: A soft‐tissue phantom study validation

Toward in vivo dosimetry in external beam radiotherapy using x‐ray acoustic computed tomography: A soft‐tissue phantom study validation

Ionizing radiation‐induced acoustics for radiotherapy and diagnostic radiology applications

X‐ray‐induced acoustic computed tomography for guiding prone stereotactic partial breast irradiation: a simulation study

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