Characterizations of the submerged fermentation of Aspergillus oryzae using a Fullzone impeller in a stirred tank bioreactor

Effect of Macroporous Support Particles on Cell Immobilization, Mass Transfer and Rheology in a Stirred Cultivation of Aspergillus oryzae Using a Swingstir® Mixer

“…Without the use of support particles, however, K was increased, from the first sampling to the end of the fermentation. Previous studies have shown that increasing the broth viscosity makes cultivation a challenge [13], [17]. These results show that utilizing large BSPs could be an easy solution to decreasing the non-Newtonian properties and preventing the obstacles that arise from a high-viscosity cell culture.…”

“…In previous reports, increasing the broth viscosity and strong shear-thinning behavior of fermented fluid was presented a challenge for fungal cultivation [13], [17]. Experimental studies show the power-law model for fermentation fluid even under immobilization conditions.…”

Multiphase stirred‐tank bioreactors – New geometrical concepts and scale‐up approaches

“…As with Liu and Gu et al [35,37] large impellers were already discussed in a first way, Ghobadi and Xie et al [31,38,39] are worth mentioning as well, comparing the performance of rigid large impellers with combinations of 6-SBDTs. In these three studies, aeration of non-Newtonian liquids was investigated while Ghobadi et al [38,39] specifically studied cultivations. Xie et al [31] was already mentioned for the comparison of multiple impeller combinations.…”

Multiphase Stirred Tank Bioreactors – New Geometrical Concepts and Scale‐up Approaches

“…As with Liu and Gu et al , large impellers were already discussed in a first way, Ghobadi and Xie et al , , are worth mentioning as well, comparing the performance of rigid large impellers with combinations of 6‐SBDTs. In these three studies, aeration of non‐Newtonian liquids was investigated while Ghobadi et al , specifically studied cultivations. Xie et al was already mentioned for the comparison of multiple impeller combinations.…”

“…Ghobadi et al , compared two large low‐frequency impellers (Maxblend®, MB, FZ) with a combination of two 6‐SBDTs. In both cases, at comparable P / V a more homogeneous bulk phase with good fungi suspension and k L a was found for the large impellers, while the MB showed higher average shear values in comparison to the two 6‐SBDTs.…”