Abstract:High-throughput immunoglobulin sequencing (IgSeq) has been developed and applied to study the adaptive immune response extensively for more than a decade. However, generating large-scale, high-fidelity sequencing data is still challenging, and furthermore, not much has been done to characterize adjuvants' effects at the repertoire level. Thus, we developed an improved library prep protocol and standardized the data analysis pipeline for accurate repertoire profiling. In addition, two metrics were implemented t… Show more
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