Characterizing Donor-Derived Cells in Nonhematopoietic Tissue

Ramakrishnan, Aravind; Shi, Daqing; Torok‐Storb, Beverly

doi:10.1016/j.bbmt.2006.05.003

Biology of Blood and Marrow Transplantation

2006

DOI: 10.1016/j.bbmt.2006.05.003

|View full text |Cite

Characterizing Donor-Derived Cells in Nonhematopoietic Tissue

Aravind Ramakrishnan

Daqing Shi

Beverly Torok‐Storb

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2013

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Phylogeny, Regeneration, Ageing and Cancer: Role of Microenvironment and Possibility of Its Therapeutic Manipulation

Smetana,

Dvořánková,

Lacina

2013

Fol. Biol.

View full text Add to dashboard Cite

Data about the possible correlation between reduction of the regeneration capacity in the course of phylogeny and formation of malignant tumours have been summarized from invertebrates to mammals. The evolutionarily increasing complexity of body building plane and expectancy of longevity in the course of phylogeny seems to be grossly negatively correlated with diminished regeneration capacity, but positively with increased occurrence of malignant tumours. A certain evolution-based switch-off mechanism reducing the extent of regeneration in developmentally complicated and long-living animals such as mammals and birds can be hypothesized and benefits of loss of this ability are discussed. This high incidence of malignancies seems to be related, in addition to other factors, to prolonged and cumulative exposure to cancerogenic stimuli in the course of lifetime. Longevity, supported by the progress and availability of medical care to the population, has been unveiling this phenomenon during recent decades. From this point of view, ageing represents the main risk for cancer acquisition. The probable role of microenvironment in all the discussed phenomena such as healing/regeneration, inflammation, and cancer is discussed and targeting of microenvironment is consequently predicted as a possible therapeutic target where controlled manipulation may represent a new approach to the treatment of cancer patients.

show abstract

Phylogeny, Regeneration, Ageing and Cancer: Role of Microenvironment and Possibility of Its Therapeutic Manipulation

Smetana,

Dvořánková,

Lacina

2013

Fol. Biol.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Characterizing Donor-Derived Cells in Nonhematopoietic Tissue

Cited by 1 publication

References 12 publications

Phylogeny, Regeneration, Ageing and Cancer: Role of Microenvironment and Possibility of Its Therapeutic Manipulation

Phylogeny, Regeneration, Ageing and Cancer: Role of Microenvironment and Possibility of Its Therapeutic Manipulation

Contact Info

Product

Resources

About