Characterizing the gut microbiota in adults with bipolar disorder: a pilot study

McIntyre, Roger S.; Subramaniapillai, Mehala; Shekotikhina, Margarita; Carmona, Nicole E.; Lee, Yena; Mansur, Rodrigo B.; Brietzke, Elisa; Fus, Dominika; Coles, Alexandria S.; Iacobucci, Michelle; Park, Caroline; Potts, Ryan; Amer, Merwa; Gillard, Jessica; James, Cindy; Anglin, Rebecca; Surette, Michael G.

doi:10.1080/1028415x.2019.1612555

Cited by 46 publications

(41 citation statements)

References 30 publications

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“…Forty-two percent of the studies assessed the diet of participants in any way, 7% used a food frequency questionnaire, and 10% used food diaries ( 3 , 26 , 28 , 30 , 36 , 51 , 52 , 54 , 58 , 79 , 85 , 89 ) (Supplementary Table 3, http://links.lww.com/PSYMED/A747 ).…”

Section: Resultsmentioning

confidence: 99%

Gut Microbiota in Psychiatric Disorders: A Systematic Review

et al. 2021

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Section: Resultsmentioning

confidence: 99%

Gut Microbiota in Psychiatric Disorders: A Systematic Review

et al. 2021

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“…Decreased microbial diversity and a greater abundance of a Clostridiaceae OTU was observed in BD patients. In addition, a greater abundance of in Collinsella was reported in BD‐II relative to BD‐I subjects, indicating a potential divergence of microbial composition in different subtypes of BD 44 . Painold et al performed 16s rRNA sequencing of stool samples from 32 BD patients and 10 HCs.…”

Section: Gut Microbiome and Bd In Human Studiesmentioning

confidence: 99%

Gut microbial clues to bipolar disorder: State‐of‐the‐art review of current findings and future directions

Lai

Jiang

Zhang

et al. 2020

Clinical & Translational Med

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Trillions of microorganisms inhabiting in the human gut play an essential role in maintaining physical and mental health. The connections between gut microbiome and neuropsychiatric diseases have been recently identified. The pathogenesis of bipolar disorder, a spectrum of diseases manifesting with mood and energy fluctuations, also seems to be involved in the bidirectional modulation of the microbiome‐gut‐brain (MGB) axis. In this review, we briefly introduce the concept of MGB axis, and then focus on the previous findings in human studies associated with bipolar disorder. These studies provided preliminary evidences on the gut microbial alterations in bipolar disorder. Limitations in these studies and future directions in this research field, such as fecal microbiome transplantation and microbiome‐targeted therapy, were discussed. A research framework linking gut microbiome to determinants and health‐related outcomes in BD was also proposed. Better characterizing and understanding of gut microbial biosignatures in bipolar patients contribute to clarify the etiology of this intractable disease and pave the new way for treatment innovation.

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“…A growing body of research finds that gut microbiota in bipolar patients is different from that in normal persons. In bipolar disorder patients, Clostridiaceae is found more abundant than that in HCs (14). Two studies observed the decline of Faecalibacterium in bipolar disorder subjects (15, 16), which is related to better self-reported health states (16).…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota in Bipolar Depression and Its Relationship to Brain Function: An Advanced Exploration

Lai

Lü

et al. 2019

Front. Psychiatry

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The mechanism of bipolar disorder is unclear. Growing evidence indicates that gut microbiota plays a pivotal role in mental disorders. This study aimed to find out changes in the gut microbiota in bipolar depression (BD) subjects following treatment with quetiapine and evaluate their correlations with the brain and immune function. Totally 36 subjects with BD and 27 healthy controls (HCs) were recruited. The severity of depression was evaluated with the Montgomery-Asberg depression rating scale (MADRS). At baseline, fecal samples were collected and analyzed by quantitative polymerase chain reaction (qPCR). T lymphocyte subsets were measured to examine immune function. Near-infrared spectroscopy (NIRS) was used to assess brain function. All BD subjects received quetiapine treatment (300 mg/d) for four weeks, following which the fecal microbiota and immune profiles were reexamined. Here, we first put forward the new concept of brain-gut coefficient of balance (B-GCB), which referred to the ratio of [oxygenated hemoglobin]/(Bifidobacteria to Enterobacteriaceae ratio), to analyze the linkage between the gut microbiota and brain function. At baseline, the CD3+ T cell proportion was positively correlated with log10 Enterobacter spp count, whereas the correlativity between the other bacteria and immune profiles were negative. Log10 B-GCB was positively correlated with CD3+ T cell proportion. In subjects with BD, counts of Faecalibacterium prausnitzii, Bacteroides–Prevotella group, Atopobium Cluster, Enterobacter spp, and Clostridium Cluster IV were higher, whereas the log10 (B/E) were lower than HCs (B/E refers to Bifidobacteria to Enterobacteriaceae ratio and represents microbial colonization resistance). After treatment, MADRS scores were reduced, whereas the levels of Eubacterium rectale, Bifidobacteria, and B/E increased. The composition of the gut microbiota and its relationship to brain function were altered in BD subjects. Quetiapine treatment was effective for depression and influenced the composition of gut microbiota in patients. Clinical Trial Registration: , identifier ChiCTR-COC-17011401, URL: .

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Characterizing the gut microbiota in adults with bipolar disorder: a pilot study

Cited by 46 publications

References 30 publications

Gut Microbiota in Psychiatric Disorders: A Systematic Review

Gut Microbiota in Psychiatric Disorders: A Systematic Review

Gut microbial clues to bipolar disorder: State‐of‐the‐art review of current findings and future directions

Gut Microbiota in Bipolar Depression and Its Relationship to Brain Function: An Advanced Exploration

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