Characterizing the impact of advancing age on 500 Hz tone-burst evoked ocular–vestibular evoked myogenic potentials

Singh, Niraj Kumar; Firdose, Husna

doi:10.1007/s00405-020-06542-2

Cited by 6 publications

(14 citation statements)

References 61 publications

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“…For B81-cVEMP and B81-oVEMP, our results revealed no correlation between the raw IAR and corrected IAR with increasing age. These results are consistent with previous reports ( 14 , 25 , 27 ). The lack of change in the IAR with advancing age could be attributed to the bilateral and usually symmetrical nature of the aging process, which has been reported most often in the studies conducted on the effect of aging on hearing and balance ( 31 ).…”

Section: Discussionsupporting

confidence: 94%

“…Therefore, it is indispensable to establish the normal range of BCV-induced VEMP for different age groups. Several previous studies have reported the influence of age on oVEMP and cVEMP parameters ( 17 , 24 , 25 , 27 – 31 ). Most studies showed a significant decline in the response rates, prolongation of latencies, and reduction of oVEMP and cVEMP amplitudes with increasing age ( 24 , 33 ).…”

Section: Discussionmentioning

confidence: 99%

“…Age-related morphological changes may occur in the vestibular system from the end organs to the central nuclei, including loss of hair cells, decreased numbers of vestibular nerve cells, and loss of neurons in the vestibular nucleus ( 20 – 23 ). Therefore, the effects of advancing age on the response rate, latency, and amplitude of ACS-VEMPs have been well explored ( 24 , 25 ). However, the age-related impact on the B81-VEMPs remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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B81 Bone Vibrator-Induced Vestibular-Evoked Myogenic Potentials: Normal Values and the Effect of Age

et al. 2022

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ObjectiveTo define the normal values and examine the influence of aging on B81 bone vibrator-induced cervical vestibular-evoked myogenic potentials (B81-cVEMPs) and ocular vestibular-evoked myogenic potentials (B81-oVEMPs).MethodsSeventy healthy subjects, divided into seven groups according to their ages, were enrolled in this study. The 4–9-, 10–19-, 20–29-, 30–39-, 40–49-, 50–59-, and 60–70-year-old participants were divided into groups I–VII, respectively. B81-cVEMP and B81-oVEMP were recorded in each group.ResultsThe B81-cVEMP response rates for groups I–VII were 100, 100, 100, 100, 95, 95, and 75%, respectively, with significant differences only between groups I–VI and group VII (p = 0.047, p < 0.05). The B81-oVEMP response rates for groups I–VII were 100, 100, 100, 100, 70, 65, and 40%, respectively, with significant differences only between groups I–IV and groups V–VII (p = 0.020, p = 0.008, p = 0.000; p < 0.05). The threshold, P13, and N23 latencies of B81-cVEMP positively correlated with age (r = 0.756, p = 0.000; r = 0.357, p = 0.003; r = 0.316, p = 0.009; p < 0.05). The raw amplitudes and corrected amplitudes negatively correlated with age (r = −0.641, p = 0.000; r = −0.609, p = 0.000, p < 0.05). For B81-oVEMP, the corrected amplitudes negatively correlated with age (r = −0.638, p = 0.000, p<0.05), but the threshold and N10 latency positively correlated with age (r = 0.768, p = 0.000; r = 0.334, p = 0.009, p < 0.05). Moreover, the interaural asymmetry ratio did not significantly correlate with age for B81-cVEMP and B81-oVEMP.ConclusionAs age increased, the B81-cVEMP response rate decreased, the thresholds increased, P13 and N23 latencies were prolonged, and the raw amplitude and corrected amplitude decreased. The B81-oVEMP response rate and corrected amplitude decreased, the thresholds increased, and N10 latency was prolonged with age. These changes are probably due to the occurrence of morphological and functional changes in the vestibular system with aging. Therefore, we suggest establishing different reference values according to different age groups when evaluating the VEMP results in patients with vestibular diseases.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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B81 Bone Vibrator-Induced Vestibular-Evoked Myogenic Potentials: Normal Values and the Effect of Age

et al. 2022

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“…Participants were instructed to lie down comfortably on an examination bed and avoid any extraneous movements of the body, limb, or neck. The electrode configuration included the placement of the active electrode approximately 1 cm below the lower eye-lid closest to the inferior oblique when staring up, the reference electrodes cross-posted 2 cm below the active electrode, and the ground electrode on the forehead, as found to be optimal and used previously ( 4 , 28 ). Before electrode installation, the skin overlying the electrode locations was cleaned with a commercially available abrasive skin preparation gel to reduce electrode impedance.…”

Section: Methodsmentioning

confidence: 99%

“…Aging causes continuous deterioration of human body, including the vestibular system ( 1 , 2 ). Although the effects of aging on the functioning of the semicircular canals and saccule have been extensively investigated ( 3 , 4 ), its impact on the utricle remains the least studied component.…”

Section: Introductionmentioning

confidence: 99%

Effects of aging on ocular vestibular-evoked myogenic potential using ER-3A insert earphone and B81 bone vibrator

Wang

Zhong

et al. 2022

Front. Neurol.

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PurposeAging is a process associated with degeneration and dysfunction of peripheral vestibular system or apparatus. This study aimed to investigate the influence of aging on ocular vestibular-evoked myogenic potential (oVEMP) response rates and recording parameters using the B81 bone vibrator and compare them with air conduction stimuli (ACS) oVEMP response characteristics.MethodsIn 60 healthy participants aged 10–71 years (mean age 39.9; 29 male participants), the oVEMP response was elicited using a B81 bone vibrator and an ER-3A insert earphone. The effects of age and stimulus on oVEMP response rates and recording parameters were evaluated.ResultsResponse rates and amplitudes declined with aging using either ACS or bone-conducted vibration (BCV) stimulation, particularly in individuals over 60 years of age, whereas thresholds increased and N1 latencies were prolonged. BCV showed fewer risks of absent oVEMP response than ACS (p = 0.002). BCV acquired higher amplitudes (p < 0.001), lower thresholds, and shorter N1 and P1 latencies (all p < 0.001) than ACS.ConclusionsThe absence of an oVEMP response may be attributed to aging rather than a concurrent vestibular disorder. B81-BCV likely produces higher mechanical drives to the vestibular hair cells at safer and non-traumatic levels compared with ACS and therefore may be more likely to evoke a response in the elderly cohort, whose vestibular function and mechanical sensitivity have declined. Thus, B81-BCV stimulation is more effective and safer to elicit oVEMPs, and it should be recommended when ACS fails in the clinic, particularly in the elderly population.

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Effects of Age and Middle Ear on the Frequency Tuning of the cVEMP and oVEMP

2022

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Background Upward shift in the air conducted (AC) frequency tuning of vestibular evoked myogenic potentials (VEMPs) as an effect of aging is hypothesized to be due to the microstructural stiffening changes in the inner ear. However, with an AC stimulus, it may be possible that the shift in the frequency tuning of VEMPs as an effect of aging may also be due to contributions from the middle ear. Purpose The main aim of this study was to examine the effects of age on the frequency tuning of the cervical VEMP (cVEMP) and ocular VEMP (oVEMP) and determine the role of middle ear transmission characteristics in shaping these effects. Research Design Standard group comparison. Study Sample One-hundred seven participants divided in three groups: young adult, middle-age, and older adults with “normal” middle ear and negative history of neurological or vestibular complaints. Data Collection and Analyses Middle ear measures included static admittance and middle ear resonant frequency. cVEMP and oVEMPs were elicited with AC tone bursts at 500, 750, and 1,000 Hz. Results No significant effect of age was observed on any of the middle ear measures. There was a significant effect of age on the amplitude of the cVEMP, but this effect was frequency specific. The age-related reduction in cVEMP corrected amplitude was only observed when the eliciting stimulus was 500 or 750 Hz, with no significant effect observed with a 1,000 Hz stimulus. For the oVEMP, the effects of age were apparent at all stimulus frequencies. We also observed a general upward shift in the frequency tuning of both the cVEMP and oVEMP for middle-age and older adults, with 750 and 1,000 Hz yielding higher response rates and larger amplitudes among middle-aged and older adults. Measurements of middle ear did not significantly contribute to the observed findings. Conclusions The upward shift in frequency tuning of VEMPs among middle age and older adults could be due to the changes in the vestibular system and not from the middle ear. These results support the use of different frequency stimuli (i.e., 750 or 1,000 Hz) to elicit a VEMP if a response is absent using a 500 Hz stimulus, especially in patients over the age of 40.

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Characterizing the impact of advancing age on 500 Hz tone-burst evoked ocular–vestibular evoked myogenic potentials

Cited by 6 publications

References 61 publications

B81 Bone Vibrator-Induced Vestibular-Evoked Myogenic Potentials: Normal Values and the Effect of Age

B81 Bone Vibrator-Induced Vestibular-Evoked Myogenic Potentials: Normal Values and the Effect of Age

Effects of aging on ocular vestibular-evoked myogenic potential using ER-3A insert earphone and B81 bone vibrator

Effects of Age and Middle Ear on the Frequency Tuning of the cVEMP and oVEMP

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