2024
DOI: 10.1002/chem.202400594
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Characterizing the Oligomers Distribution along the Aggregation Pathway of Amyloid Aβ1‐40 by NMR

Katiuscia Pagano,
Lucia De Rosa,
Simona Tomaselli
et al.

Abstract: This study delves into the early aggregation process of the Aβ1‐40 amyloid peptide, elucidating the associated oligomers distribution. Motivated by the acknowledged role of small oligomers in the neurotoxic damage linked to Alzheimer’s disease, we present an experimental protocol for preparing 26‐O‐acyl isoAβ1‐40, a modified Aβ1‐40 peptide facilitating rapid isomerization to the native amide form at neutral pH. This ensures seed‐free solutions, minimizing experimental variability. Additionally, we demonstrate … Show more

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