Characterizing the phenotypic and genetic changes of pre‐epidemic <scp>HIV</scp>‐2 group F virus following serial passage in humanized mice

Curlin, James Z.; Schmitt, Kimberly; Remling‐Mulder, Leila; Tibbitts, Corina Valencia; O'Connor, Shelby; Marx, Preston; Akkina, Ramesh

doi:10.1111/jmp.12674

J of Medical Primatology

2023

DOI: 10.1111/jmp.12674

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Characterizing the phenotypic and genetic changes of pre‐epidemic HIV‐2 group F virus following serial passage in humanized mice

James Z. Curlin,

Kimberly Schmitt,

Leila Remling‐Mulder

et al.

Abstract: HIV‐2 Group F virus with an origin in NHPs was isolated from only two individuals. Two serial passages in hu‐mice showed increased viral loads, CD4+ T cell decline and nonsynonymous genetic changes showing its capacity for further evolution, and spread in the human.

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Characterizing the phenotypic and genetic changes of pre‐epidemic HIV‐2 group F virus following serial passage in humanized mice

Abstract: HIV‐2 Group F virus with an origin in NHPs was isolated from only two individuals. Two serial passages in hu‐mice showed increased viral loads, CD4+ T cell decline and nonsynonymous genetic changes showing its capacity for further evolution, and spread in the human.

Cited by 0 publications

References 23 publications

No citations

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