2021
DOI: 10.1101/2021.12.16.473000
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Characterizing the variation in chromosome structure ensembles in the context of the nuclear microenvironment

Abstract: Inside the nucleus, chromosomes are subjected to direct physical interaction between different components, active forces, and thermal noise, leading to the formation of an ensemble of three-dimensional structures. However, it is still not well understood to what extent and how the structural ensemble varies from one chromosome region or cell-type to another. We designed a statistical analysis technique and applied it to single-cell chromosome imaging data to reveal the fluctuation of individual chromosome stru… Show more

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