Chardon à glu

Hammiche, Victoria; Merad, Rachida; Azzouz, Mohamed

doi:10.1007/978-2-8178-0375-3_12

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…In Morocco, A. gummifera is one of the most used herbs in alternative medicine (3), particularly in the treatment of edemas, psoriasis and epilepsy, to stop hemorrhages and facilitate childbirth (30)(31)(32)(33).…”

Section: Traditional Use Of a Gummiferamentioning

confidence: 99%

“…Morocco, with its 7000 plant species, is a true phytotherapy reservoir that allows it to occupy a privileged place among the countries around the Mediterranean region which have a long medicinal culture and ancestral herbal know-how (1,2). However, several of these medicinal plants are the origin of poisonings, which are accidental most of the time and sometimes happen voluntary, thus constituting a rather serious public health problem (3,4). In this respect, the World Health Organization (WHO) estimates that 80% of the world's population uses plants as primary health care methods, which increases the risk of poisoning by plants (5,6).…”

Section: Introductionmentioning

confidence: 99%

“…In this respect, the World Health Organization (WHO) estimates that 80% of the world's population uses plants as primary health care methods, which increases the risk of poisoning by plants (5,6). Indeed, several plants around the Mediterranean have therapeutic uses, but they can cause serious poisoning if they are not used properly (3). Hence, the need to study these plants and conducts phytochemical, pharmacological and toxicological studies are a pressing necessity to rationalize their use.…”

Section: Introductionmentioning

confidence: 99%

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Inventory of poisonings and toxicological studies carried out on Atractylis gummifera L.: A review

et al. 2019

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Atractylis gummifera L. belongs to the family Asteraceae is widely used in traditional Moroccan medicine for its therapeutic effects (diuretic, purgative, emetic, abortive), but it causes serious and fatal poisonings, hence the objective of this work is to describe the current state of intoxication caused by A. gummifera in the Mediterranean and to summarize the toxicological studies carried out on this plant. The working methodology we adopted consisted in collecting data published in Arabic, French and English in specialized articles, books and on websites. Research results showed that the Centre Anti Poison and Pharmacovigilance of Morocco declared A. gummifera was in second place in the occurrence of poisonings in between January 1980 and December 2008. The synthesis of experimental work on plant toxicology showed that the lethal dose of A. gummifera varies according to the animal model used (rat or mouse), the route of administration (intraperitoneal, oral or intravenous) and the part of the plant used. The root has been found to be the most toxic part of the plant. The toxicity of A. gummifera is due to atractyloside and gummiferine, which are inhibitors of oxidative phosphorylation that prevent the formation of ATP from ADP in intracellular organelles. This study shows the interest in raising public awareness of the toxicity of A. gummifera and in rationalizing its use in traditional medicine.

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Section: Traditional Use Of a Gummiferamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inventory of poisonings and toxicological studies carried out on Atractylis gummifera L.: A review

et al. 2019

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Structural characterization of carboxyatractyloside and acaricidal activity of natural ent-kaurene diterpenoids isolated from Chamaeleon gummifer against Tetranychus urticae

Badalamenti,

Bruno,

Pavela

et al. 2023

J Pest Sci

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Plant-borne secondary metabolites are attracting high interest for their potential use in agricultural applications, with special reference to the control of arthropod pests. In the present work, the structural elucidation of glycosylated diterpenoid carboxyatractyloside (2) isolated from the roots of Chamaeleon gummifer Cass. (Asteraceae) is reported by means of spectroscopic and spectrometric techniques. Complete identification occurred thanks to one- and two-dimensional NMR experiments, assigning the single protons and carbons, and the stereochemistry by the NOESY correlations. Carboxyatractyloside (2), together with two ent-kaurenes atractyloside (1) and atractyligenin (3), extracted from the roots of C. gummifer, have been tested for their acaricidal and oviposition inhibition activity against the two-spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae) Notably, compounds 1–3 were toxic to T. urticae, leading to significant mortality, oviposition inhibition, reduced hatchability of eggs, and natality inhibition. However, at the lowest dose (12.5 µg cm−2) compound 2 was the most effective, leading to mortality > 60% after 5 days exposure, inhibiting oviposition by > 70% and egg hatching by 33%; it also reduced natality by 80%. Overall, these compounds represent valuable candidates to develop novel acaricides for crop protection. Further research on how to develop stable formulations for field use, as well as on non-target effects of these compounds on pollinators and mite biocontrol agents, is ongoing.

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Chardon à glu

Cited by 2 publications

References 24 publications

Inventory of poisonings and toxicological studies carried out on Atractylis gummifera L.: A review

Inventory of poisonings and toxicological studies carried out on Atractylis gummifera L.: A review

Structural characterization of carboxyatractyloside and acaricidal activity of natural ent-kaurene diterpenoids isolated from Chamaeleon gummifer against Tetranychus urticae

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