Charge-dependent interaction of self-emulsifying oil formulations with Caco-2 cells monolayers: binding, effects on barrier function and cytotoxicity

Gershanik, Tatyana; Haltner, Eleonore; Lehr, Claus‐Michael; Benita, Simon

doi:10.1016/s0378-5173(00)00591-3

Cited by 65 publications

(43 citation statements)

References 21 publications

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“…The results of the current study are in agreement with Gershanik, Haltner, Lehr, and Benita (2000) who demonstrated a concentration-dependent reduction in mitochondrial dehydrogenase activity (e.g. a decrease in cell viability), for emulsions containing Tween 80.…”

Section: Discussionsupporting

confidence: 92%

Capacity of natural β-carotene loaded microemulsion to protect Caco-2 cells from oxidative damage caused by exposure to H2O2

Roohinejad

Middendorf

Burritt

et al. 2014

Food Research International

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Section: Discussionsupporting

confidence: 92%

Capacity of natural β-carotene loaded microemulsion to protect Caco-2 cells from oxidative damage caused by exposure to H2O2

Roohinejad

Middendorf

Burritt

et al. 2014

Food Research International

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“…It is reported that in addition to free energy and particle size, zeta potential also plays an important role in the interactions with mucus of the gastrointestinal tract (Gershanik et al, 2000;Wei et al, 2005). In our study, the surface charge of the formed emulsion was positive for the droplets in 0.1 N HCl, suggesting the formulated SNEDDS would reach a positive zeta potential at stomach pH.…”

Section: Discussionsupporting

confidence: 48%

Novel self-nanoemulsifying drug delivery system for enhanced solubility and dissolution of lutein

et al. 2010

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Self-nanoemulsifying drug delivery system (SNEDDS) containing oil (Phosal 53 MCT), surfactant (Labrasol), and cosurfactant (Transcutol-HP or Lutrol-E400) was prepared to enhance solubility and dissolution of lutein. Ternary phase diagram of the SNEDDS was constructed to identify the self-emulsifying regions following which the percentage of oil, surfactant, and cosurfactant in the SNEDDS were optimized in terms of emulsification time and mean emulsion droplet size. The optimized SNEDDS consists of 25% oil, 60% surfactant, and 15% cosurfactant. When measured using USP XXIII dissolution apparatus II, the emulsification time of the SNEDDS prepared with Transcutol-HP as cosurfactant was less than 20 sec, and it was 20-30 sec in the SNEDDS prepared with Lutrol-E400. Mean emulsion droplet size was slightly smaller when Transcutol-HP was used as cosurfactant (80 +/- 6 nm), compared to when Lutrol- E400 was used (93 +/- 6 nm). Dissolution of lutein from the solid SNEDDS (physical mixture of the optimized SNEDDS and Aerosil 200) took place immediately (less than 5 min) in distilled water, and, once dissolved, no precipitation or aggregation of the drug were observed. In contrast, no drug was released from lutein powder or from the commercial product (Eyelac(R)) until 3 h of the study duration.

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“…Y = yeast. face of cells would certainly decrease this effect (35). Clearly this may also impair the effectiveness of particulate penetration enhancers such as yeast.…”

Section: Discussionmentioning

confidence: 99%

Disruption of Epithelial Tight Junctions by Yeast Enhances the Paracellular Delivery of a Model Protein

Fuller

Duckham²,

Wood

2006

Pharm Res

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Charge-dependent interaction of self-emulsifying oil formulations with Caco-2 cells monolayers: binding, effects on barrier function and cytotoxicity

Cited by 65 publications

References 21 publications

Capacity of natural β-carotene loaded microemulsion to protect Caco-2 cells from oxidative damage caused by exposure to H2O2

Capacity of natural β-carotene loaded microemulsion to protect Caco-2 cells from oxidative damage caused by exposure to H2O2

Novel self-nanoemulsifying drug delivery system for enhanced solubility and dissolution of lutein

Disruption of Epithelial Tight Junctions by Yeast Enhances the Paracellular Delivery of a Model Protein

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