Charge heterogeneity in wildtype and variant glucocorticoid receptors

Inhibition of glucocorticoid-induced changes of Na+, K+-ATPase in rat lens by a glucocorticoid receptor antagonist RU486

“…Agonist ligand binding activates the receptor by induction of a conformational change, resulting in dissociation of heat shock proteins and hyperphosphorylation of the receptor [62]. The ligand-receptor complex translocates to the nucleus, dimerizes, and binds to a cis-acting element, GRE, typically present in the 5′ flanking region of the target genes [63].…”