Charge reduced nanoparticles by sub-kHz ac electrohydrodynamic atomization toward drug delivery applications

Abstract

In this letter, we present an electrohydrodynamic atomization (EHDA) technology that generates and delivers charge reduced nanoparticles to open space without collector electrode. The backward ring-nozzle ac EHDA system driven at sub-kHz frequencies generates alternatively charged particles which exert electric force and recombine in the vicinity of the spraying electrode. This unique configuration creates a stable jet stream of charge reduced nanoparticles, to the contrary of classical dc EHDA systems. Experiments indicate that nanoparticles are emitted through a wide range of voltages and frequencies, match up to the hydrodynamic time of the cone jet model. These unique advantages of the new system would

Electrospinning/electrospraying coatings for metal microneedles: A design of experiments (DOE) and quality by design (QbD) approach

“…It is evident from extensive research surrounding EHDA process synthesises that highly charged droplets and hence charged structures [5]. This can potentially result in repulsion between surfaces of similar charge, ergo fabricating a non-uniform coating, regardless of charge dissipation upon deposition [70][71]. It is important to note here the overall MN coating has the same quantity of particles and fibers required by mass.…”

Charge-Reduced Particles via Self-Propelled Electrohydrodynamic Atomization for Drug Delivery Applications

“…33,34 Another technique involves applying alternating current (AC) instead of direct current to ES. 35,36 In this AC electrospray, oppositely charged particles are alternatively generated at suitable frequencies so that they can recombine and neutralize each other 37 or by resonating the liquid meniscus at the nozzle tip at very high frequencies. 38,39 Within the field of electrohydrodynamic, there is a need for a solution that allows simultaneous neutralization and delivery of particles.…”

Simultaneous Generation and Delivery of Neutral Polymeric Aerosol by Electro-Hydrodynamic Nebulizer

“…1) which ultimately needs additional steps for practical use. Hence, in addition to size, charge-neutral particles imply several advantages in the field of inhalational drug delivery: (i) they can go through narrow airways instead of being attracted to the surrounding wall [6], and (ii) exclude the need of neutralizing particles before use. In this paper, we introduced a novel eNeb concept that can generate electroneutral particles and deliver them simultaneously.…”