2016
DOI: 10.1016/j.ijbiomac.2016.01.054
|View full text |Cite
|
Sign up to set email alerts
|

Charged pullulan derivatives for the development of nanocarriers by polyelectrolyte complexation

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

2
12
0

Year Published

2017
2017
2021
2021

Publication Types

Select...
5
2

Relationship

0
7

Authors

Journals

citations
Cited by 33 publications
(14 citation statements)
references
References 39 publications
2
12
0
Order By: Relevance
“…However, on reaching −/+ charge ratios of 0.98, 1.06 and 1.21 precipitation occurred (CS/LBGS nanoparticles 1:3.25 to 1:4; w/w). Although this behavior was unexpected, it has been reported in other works regarding polysaccharide nanoparticles produced by the same methodology [32][33][34][35][36].…”
Section: Characterization Of Unloaded Cs/lbgs Nanoparticlessupporting
confidence: 59%
“…However, on reaching −/+ charge ratios of 0.98, 1.06 and 1.21 precipitation occurred (CS/LBGS nanoparticles 1:3.25 to 1:4; w/w). Although this behavior was unexpected, it has been reported in other works regarding polysaccharide nanoparticles produced by the same methodology [32][33][34][35][36].…”
Section: Characterization Of Unloaded Cs/lbgs Nanoparticlessupporting
confidence: 59%
“…The most remarkable observation in the whole set of cell viability assessment is that, in spite of the strong decrease in cell viability induced by the contact with LBGA, this effect was completely reverted when the cells were exposed to a nanoparticulate form of the derivative. This was also observed in works using an ammonium derivative of pullulan, in which the derivative elicited around 40% cell viability upon 24 h of exposure, while nanoparticles produced with the polymer registered increased cell viabilities to values of 70% -80% (Dionísio, Braz, Corvo, Lourenço, Grenha & da Costa;Dionísio, Cordeiro, Remuñán-López, Seijo, Rosa da Costa & Grenha, 2013). The different impact on cell viability generated by LBGA in form of polymer and of nanoparticles is possibly explained by a differential contact of each of the materials with the cells.…”
Section: Safety Evaluationsupporting
confidence: 63%
“…Comparing to LBGA, a very similar toxicological profile was observed for an ammonium derivative of another polysaccharide, pullulan, which was synthesized using the same methodology (Dionísio, Braz, Corvo, Lourenço, Grenha & da Costa, 2016;Dionísio, Cordeiro, Remuñán-López, Seijo, Rosa da Costa & Grenha, 2013). In that case, the assessment was performed in Calu-3 cells (bronchial cell line) and cell viabilities around 50-60% were observed after 3 h, decreasing to 40% at 24 h. Although a time-dependent effect is also clearly observed, the effect on cell viability is not as strong as for LBGA.…”
Section: Safety Evaluationmentioning
confidence: 76%
See 2 more Smart Citations